New research by HHMI scientists shows that the emotional memory of an experience is malleable.
Janelia scientists are learning how the brain makes sense of new places.
HHMI scientists have devised a technique to identify hard-to-find gene mutations that crop up in a fraction of the body's cells.
By studying dirty flies, Janelia scientists hope to learn how animals carry out sequences of movements that make up more complex behaviors.
The September 17 lecture, “Unraveling Infectious Disease Mysteries Through Genomics,” is free, but tickets are required for admission.
The Howard Hughes Medical Institute awards nearly $5 million in research fellowships to 46 predoctoral students from 24 countries.
Big data can mean big headaches for scientists. A new library of software tools from Janelia speeds analysis of data sets so large and complex they would take days or weeks to analyze on a single workstation—if a single workstation could do it at all.
Janelia researchers develop a new computational method that can essentially automate much of the time-consuming process of reconstructing an animal's developmental building plan cell by cell.
Fifteen outstanding researchers from 13 institutions are named HHMI Professors.
HHMI and GBMF announce the establishment of an Advanced Imaging Center at Janelia that will make leading-edge imaging technologies more widely available to the scientific community before the instruments are available commercially.
Every millisecond counts when a fruit fly is being hunted by a damselfly. Janelia scientists find that fruit flies can deploy two escape behaviors, depending on circumstances.
HHMI researchers find that a single-letter change in the genetic code is enough to generate blond hair in humans.
HHMI selects 37 research universities to receive $60 million in grants to improve how science is taught.
Through its 2014 Sustaining Excellence competition, HHMI is awarding new science education grants that will support activities at 37 research universities.
Peter Walter shares prize for discovery of the unfolded protein response of the endoplasmic reticulum.
The University of Maryland, Baltimore County, the Pennsylvania State University, the University of North Carolina at Chapel Hill, and HHMI are working together to learn how to adapt the Meyerhoff Scholars Program at more universities.
HHMI scientists are among ten newly elected foreign members.
HHMI scientists are among 84 newly elected members.
HHMI scientists develop new tool to silence neurons with an unprecedented level of control.
Ten HHMI investigators are elected to the American Academy of Arts and Sciences.
Seventy medical and veterinary students from 37 different schools across the country will be engaging in laboratory research for a full year as participants in the HHMI Medical Research Fellows Program.
Janelia researchers speed up image-processing time and get sharper microscopy images by employing techniques used by astonomers and ophthalmologists.
John P. Donoghue, Director of the Institute for Brain Science at Brown University, will speak on April 30 at 7PM at Janelia.
HHMI researchers have tested the olfactory capacity of human volunteers and found that humans are capable of discriminating at least one trillion different odors.
HHMI researchers show that rising temperatures can cause spread of malaria to areas where the disease had not been endemic historically.
Investigadores del HHMI demuestran que el aumento de temperaturas puede causar la dispersión de la malaria en zonas donde la enfermedad no ha sido endémica históricamente.
Howard Hughes Medical Institute (HHMI) scientists have created a portrait of a DNA-snipping protein called Cas9, a powerful research tool used in many labs for genome editing.
In the last five years, 4,800 students at 73 colleges and universities nationwide have taken HHMI's Science Education Alliance (SEA) Phage Hunters Advancing Genomics and Evolutionary Science (PHAGES) research course.
New research from HHMI scientists reveals how a foreign-DNA-destroying system, known as CRISPR, efficiently locates its DNA targets within a bacterial genome.
By studying which genes modern humans still retain from our Neanderthal ancestors, researchers are able to tell a clearer story about the biological impact of human-Neanderthal interbreeding.
In his "Dialogues of Discovery" talk at Janelia on February 26, 2014, HHMI investigator Jeremy Nathans will explore the diverse ways in which color vision has evolved.
HHMI seeks to appoint up to 25 new biomedical researchers through a national open competition.
Janelia neurobiologist Igor Siwanowicz wins first prize in the 2013 Olympus BioScape Digital Imaging Competition with a photo that shows the gaping trap of an aquatic carnivorous plant, humped bladderwort about to consume microinvertebrates.
HHMI investigator is among 6 honored for excellence in research aimed at curing intractable diseases and extending human life.
HHMI researchers identify a potential Achilles heel in the oncogene K-Ras.
A new technique developed by Janelia researchers allows scientists to use electron beams to determine protein structure from tiny crystals.
The Howard Hughes Medical Institute (HHMI) is adding four new films to its award-winning catalog of short science documentaries for the classroom.
Ulrike Heberlein, a scientific program director and laboratory head at the Janelia Farm Research Campus, will deliver a public lecture at Janelia titled, “Alcoholism: 100 Million Years in the Making?”
New evidence suggests that aneuploidy patterns of chromosome deletion or amplification that are recurrent among tumors actually represent a driving force during tumor evolution and are very frequent in cancer.
HHMI researchers have discovered that the pool of inactive HIV viruses that lingers silently in a patient’s body is larger than expected. The viruses continue to be a threat because they retain the ability to become active even after treatment with the best HIV drugs.
Six HHMI scientists have been elected to membership in the Institute of Medicine.
HHMI researchers have developed a mouse model of scleroderma. Their studies have uncovered some of the molecular pathways that go awry to cause the disease.
Neurons deep in the fly’s brain tune in to some of the same basic visual features that neurons in bigger animals such as humans pick out in their surroundings. The new research is an important milestone toward understanding how the fly brain extracts relevant information about a visual scene to guide behavior.
HHMI researchers have designed an inhibitor that can reduce the expression of the mutated gene that causes hypertrophic cardiomyopathy, a potentially fatal heart condition.
La Real Academia de las Ciencias Sueca anunció que los investigadores del HHMI, Randy W. Schekman y Thomas C. Südhof, y James E. Rothman de la Universidad de Yale son los ganadores del Premio Nobel de Fisiología o Medicina 2013 por sus descubrimientos sobre la maquinaria que regula el tráfico de vesículas, un importante sistema de transporte de nuestras células.
The Nobel Assembly at the Karolinska Institute announced that HHMI investigators Randy W. Schekman and Thomas C. Südhof, and Yale's James E. Rothman are the recipients of the 2013 Nobel Prize in Physiology or Medicine for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells.
Janelia scientists launch collaboration to develop a new generation of devices to detect neural activity.
Some breast cancer cells have a leg up on survival—the genes they express make them more likely to spread and prosper in bone tissue.
Scientists have discovered that an active ingredient in an over-the-counter skin cream slows or stops the effects of Parkinson’s disease on brain cells.
Neuroscientist Cori Bargmann will discuss "Ancient Molecules and the Modern Brain: Understanding our Social Nature," at Janelia on September 18.
HHMI awards more than $1.8 million in fellowships to 42 international graduate students studying in the U.S.
Kathryn S. Brown, head of communications, oversees all communications and public relations for the Howard Hughes Medical Institute.
New thinking and technological innovation help Janelia researchers piece together a complex map of the neuronal connections that flies use to detect motion.
HHMI relaunches its primary public website. The new site uses Drupal, an open-source technology.
By activating a subset of brain cells in mice, researchers changed the way the animals remembered a particular setting.
New research reveals the cellular network that activates temperature-sensitive changes in an infectious fungus.
A new protein engineered by scientists at the Janelia Farm Research Campus fluoresces brightly each time it senses calcium, giving the scientists a way to visualize neuronal activity. The new protein is the most sensitive calcium sensor ever developed and the first to allow the detection of every neural impulse.
New research reveals details of changing DNA methylation patterns as the brain matures.
Proteins engineered to bind enhancer regions of the genome offer researchers a window into how genes are activated.
Scientists have identified a gene that enables wheat crops to fight off stem rust, a dreaded fungus that blights wheat fields with rusty brown lesions and reduces yields.
When injected into mice immediately following a traumatic event, a new drug prevents the animals from developing memory problems and increased anxiety that are indicative of post-traumatic stress disorder.
In one of the first successful attempts at genetically engineering mosquitoes, researchers have altered the way the insects respond to odors, including the smell of humans and the insect repellant DEET.
Identification of a cell signaling pathway that affects the levels of the toxic protein responsible for the neurodegenerative disease SCA1 could lead researchers to new drugs.
Sixty-nine medical, dental, and veterinary students from 32 schools across the country will be engaging in laboratory research for a full year as participants in the HHMI Medical Research Fellows Program.
Malaria parasites infecting human red blood cells send packets of information between cells to coordinate group activity. When the parasites are under stress, the communication increases their ability to develop into a new stage of the life cycle.
New research shows that about 10 percent of severe cases of congenital heart disease are caused by genetic mutations that are absent in the parents of affected children.
HHMI announces the selection of 27 HHMI investigators, representing 19 institutions.
Meet the 2013 HHMI Investigators
Meet the 2013 HHMI Investigators
Meet the 2013 HHMI Investigators
Meet the 2013 HHMI Investigators
Two bioengineering professors at Rice University have been named recipients of the 2013 $100,000 Lemelson-MIT Award for Global Innovation.Rebecca Richards-Kortum, an HHMI program director at Rice, and an HHMI Professor, and her colleague, Maria Oden, are being honored for mentoring a new generation of inventors in developing life-saving health technologies for the world¹s poorest communities.
Waging an immunological war against a pathogen is not the body’s only way to survive an infection. Sometimes learning to live with an invader can be just as important.
Scientists have discovered a hormone that causes the body’s insulin-producing factories, beta cells, to churn out more of themselves.
Eddy will speak about "The Language of DNA" on May 22 in an event open to the public.
HHMI has invited 203 research universities to apply for new science education grants aimed at helping improve persistence of students studying STEM disciplines and reinvigorating introductory science courses.
A new technique transforms biological tissue into an optically transparent sample that retains its original structure and molecular information.
Stephen Elledge recognized for research on DNA repair.
New research reveals how a localized source of a signaling molecule directs a dividing stem cell to produce two different cells—one identical to its parent, the other a more specialized cell type—and aligns those cells.
At a briefing at the White House, HHMI announces $22.5 million, five-year grant to help major research universities train a new generation of science and mathematics teachers.
Up to 15 new HHMI professors will receive $1 million over five years to create activities that integrate their research with student learning to enhance undergraduates' understanding of science.
The Howard Hughes Medical Institute selects nine highly talented college students to receive the 2013 Gilliam Fellowships for Advanced Study.
Researchers have found that temperatures on the surface of the tropical South Atlantic Ocean in July can predict the severity of malaria outbreaks in northwestern India that begin to peak four months later.
Scientists have a new view of the cellular machinery that assembles directly on DNA and readies it for transcription into RNA, the first step in protein production.
Misha Ahrens, Shaul Druckmann, Krystyna Keleman, and Minoru Koyama will each lead a small research team working toward learning how the brain’s neural circuits process information and guide behavior.
Stem cells inside the parasite that causes schistosomiasis can regenerate worn-down organs, which may help explain how the parasites can live for years inside their host.
Células madres en el interior del parásito que causa la esquistosomiasis pueden regenerar los órganos desgastados, lo que podría ayudar a explicar cómo pueden vivir por años o incluso décadas dentro de su huésped.
Three HHMI scientists are among 11 honored for excellence in research aimed at curing intractable diseases and extending human life.
Jennifer Tour Chayes, Managing Director of Microsoft Research New England and Microsoft Research New York City, will speak about "Age of Networks" on February 20 at 7 PM.
EarthViewer, a free, interactive app designed for the iPad, lets users explore the Earth's history with the touch of a finger by scrolling through 4.5 billion years of geological evolution.
Científicos han descubierto que arreglos periódicos de actina en forma de anillos rodean las largas fibras axonales de las células nerviosas, en contraste con las redes lineares que comúnmente le dan forma a las células.
Scientists have discovered that periodic ring-shaped actin arrangements encircle the long axonal fibers of nerve cells, in contrast to the linear meshworks that typically give cells their shapes.
HHMI scientists discover how a single molecule in a living cell can respond differently to different strengths of an external signal.
New lab heads Barry Dickson and Nikolaus Grigorieff will move to Janelia in 2013.
A new analysis suggests that the regulatory protein MeCP2 works with the modified nucleotide 5hmC to facilitate gene activation in the brain.
Scientists have discovered the molecular pathway responsible for detecting loose bits of DNA outside a cell’s nucleus and setting off an immune reaction.
Rather than scrutinizing hours of video, scientists can quickly teach the software how to recognize key behaviors.
AAAS recognizes Ulrike Heberlein and Nelson Spruston for meritorious efforts to advance science.
O'Shea, HHMI investigator and professor at Harvard University, will lead HHMI's science programs.