A immunosuppressant drug may unexpectedly fight the parasite-caused disease.
Scientists have detected a multitude of broken, missing, and overactive genes in the most detailed genetic survey yet of any human tumor.
Mediante el examen genético más detallado de cualquier tumor humano que se haya realizado hasta el momento, científicos encuentran que en tumores pancreáticos y cerebrales una variedad de genes están rotos, hiperactivos o desaparecen.
Researchers have generated insulin-producing beta cells from adult pancreatic cells in living mice.
Investigadores del HHMI han transformado células pancreáticas adultas en células betas productoras de insulina en ratones vivos.
President Bush named HHMI investigator Robert J. Lefkowitz a recipient of the National Medal of Science for contributions to the biological sciences.
Graduates of the science and technology magnet program met over the summer to create engineering courses for high school students.
A statement regarding fraudulent activity involving checks that are purported to be from HHMI.
Thomas R. Cech, Nobel laureate and president of HHMI, will deliver a public talk on "RNA Enzymes and the Origins of Life" at the Janelia Farm Research Campus in Ashburn, VA.
Researchers have begun scouring cancer cells for potential sites of resistance against a new class of drugs.
Researchers have shown that bacterial communication can be intercepted and chemically manipulated to control group behavior, such as virulence or the production of a useful products.
Researchers have converted cells from individuals with ten different diseases, including muscular dystrophy, juvenile diabetes, and Parkinson's disease, into stem cells.
Scientists have identified more than 300 human genes that influence West Nile virus infection. More than 20 of these cooperate with the virus, whereas the others help cells resist it.
Clayton, who joined HHMI in 1996, has announced that he will retire on August 31.
Researchers have used new technology to pinpoint a critical gene mutation in worms in only a few weeks. It would have taken years for scientists using older technology to sift through the worm's DNA until they found the proverbial needle in the haystack.
Researchers have identified a genetic defect that makes some children susceptible to attack by a certain type of bacteria, a finding that will speed up diagnosis and treatment.
Investigadores del HHMI han identificado dos drogas que imitan muchos de los efectos fisiológicos del ejercicio. Las drogas aumentan la capacidad de las células de quemar grasa y son las primeras sustancias que se han demostrado mejoran la resistencia para el ejercicio.
HHMI researchers have identified two drugs that mimic many of the physiological effects of exercise.
Researchers have revealed an important step in the process that guides neurons as they establish precise connections between the spinal cord and muscles.
An international team of researchers has identified a gene mutated in Duane syndrome, a common disorder that restricts the movement of the eyes.
Thanks to a set of fruit flies that seem to get by with far less dozing than most, researchers has found a gene absolutely necessary for snoozing.
By focusing on large families in which both parents share a recent ancestor, scientists have honed in on rare mutations that had remained elusive in previous studies.
HHMI-supported scientists have created MitoCarta, an online atlas of more than 1,000 proteins that healthy mitochondria use to keep cells running smoothly—a tool that should help researchers understand what happens when things go wrong.
HHMI international scholar Alan Cowman has set out to understand the proteins that oversee malaria's destruction and rebuilding of red blood cells.
Scientists may be able to stave off influenza infection by targeting one of more than 100 proteins inside host cells on which the virus depends.
Pavel Pevzner has created a class that turns undergraduates into experts on genome annotation.
HHMI has appointed Marian Carlson as senior scientific officer. Carlson will work from the Institute's headquarters to support the research of HHMI investigators across the nation.
New research has uncovered the mechanism that guides vertebral development in the early embryo.
New research has uncovered the mechanism that guides vertebral development in the early embryo.
HHMI researchers have developed a mouse model of osteosarcoma, the most common form of bone cancer.
A new model reveals that three classes of HIV drugs inhibit the virus more than 10,000 times better than others
Nuevo modelo matemático revela que tres clases de drogas contra el VIH inhiben al virus 10.000 veces mejor que otras.
Researchers have identified a chemical messenger that helps different sites on individual neurons coordinate with one another.
Medical, dental and, for the first time, veterinary students will get a chance to conduct biomedical research full time for a year.
Scientists who bridge the gap between basic research and clinical medicine will get a boost at a vital time in their career.
Scientists have demonstrated how protocells might have taken up nutrients from the earth's early environment to propel their growth.
Scientists have discovered that the mutation that causes Rett syndrome interferes with the regulation of 2,500 other genes.
Fifty-six of the nation's most creative biomedical scientists are being given the opportunity to tackle their most ambitious, risky research plans as they become the newest class of HHMI investigators.
A protein previously thought to identify only colon cancer stem cells is actually prevalent throughout primary colon tumors.
A prominent protein on the surface of liver cells protects organisms during sepsis, one of the most common and deadly side effects of bacterial infection.
HHMI researchers bring the arcane world of protein folding to the online gaming arena with the launch of "Foldit."
Investigadores del HHMI acercan el arcano mundo del plegamiento proteico al terreno de juegos en Internet con el lanzamiento de “Pliégalo”.
Researchers have produced the first high-resolution map showing the structural variation that exists in the human genome.
A mutant RNA may be partially to blame for the neurodegeneration associated with spinocerebellar ataxia type 3.
Four HHMI investigators, an HHMI professor, and two members of the Institute's advisory boards have been elected to the National Academy of Sciences.
David Asai has been named director of the undergraduate science education program at HHMI.
Eight HHMI investigators and three HHMI professors are among the 190 new fellows and 22 foreign honorary members elected.
Vision has improved in all three patients who have received gene therapy for a rare but severe form of retinal degeneration.
A searchable database of interviews with notable scientists and public figures now available from the Howard Hughes Medical Institute.
Forty-eight of the nation's best undergraduate institutions will receive $60 million to help them usher in a new era of science education.
A complete listing of this year's college grant recipients with links to profiles of each institution.
Just three years after discovering a genetic mutation that causes a trio of leukemias, HHMI researchers have helped move a new leukemia drug into clinical trials.
HHMI researchers identify rare mutations in three genes that contribute to blood pressure variation in the general population.
Investigadores del HHMI han encontrado que mutaciones raras en tres genes contribuyen a variaciones en la presión arterial de la población general.
Jeremy R. Knowles, an HHMI Trustee, died yesterday at his home in Cambridge, Massachusetts, following a long bout with prostate cancer.
A new picture of a genetic parasite is helping researchers see how specialized segments of RNA escape from their positions in the genome and invade new ones.
Thomas R. Cech, President of HHMI since January 2000, today announced that he would step down as head of the Institute in spring 2009.
A new DVD provides an in-depth look at the challenges facing physicians, scientists, and others on the front lines of the global AIDS epidemic.
New studies provide a fresh view of the computational power of neurons.
Charles Zuker will deliver a lecture titled "Common Sense about Taste–from the Tongue to the Brain: How We Transform Sensation into Perception" on April 23, 2008.
Researchers have identified hundreds of genes that keep embryonic stem cells in their characteristic malleable state.
Researchers have designed and built two functional enzymes never seen in nature.
Con la ayuda de la donación de tiempo computacional de miles de personas en todo el mundo, Investigadores del HHMI han diseñado y construido dos enzimas funcionales nunca antes vistas en la naturaleza.
A cellular gatekeeper inside a malaria parasite doesn't care whether the amino acid letters on a protein's entry ticket are out of order.
Researchers studying spinocerebellar ataxia have uncovered a pathological mechanism that may also underlie more common neurological diseases.
HHMI announces a major new program that will provide much-needed support to some of the nation's best early career faculty.
View the complete list of eligible institutions.
Metastatic colon cancers carry the ability to metastasize from the time they become cancerous, and don't need to acquire any new genetic mutations to become metastatic.
A fruit fly's misguided neurons provide a fascinating look at the evolution of systems that detect carbon dioxide.
People who lack a certain large segment of DNA have a previously unrecognized syndrome characterized by mental retardation, seizures, and slight physical abnormalities.
HHMI researchers have developed novel techniques and software that will provide scientists with the tools they need to decipher large-scale patterns in the vital - but little-understood - process of DNA methylation.
Investigadores del HHMI han desarrollado técnicas y software nuevos que les proveerán a los científicos de las herramientas necesarias para descifrar patrones de metilación a gran escala en el vital –pero poco entendido– proceso de metilación de ADN.
Malaria-causing parasites evade the immune system by ducking in and out of cells.
Certain regions inside the nucleus can prevent the genes inside them from becoming activated.
HHMI researchers have uncovered a protein that stops the growth of melanoma.
A new microscopy technique allows researchers to examine the complete three-dimensional morphology of many of the tiniest structures of cells.
Investigadores del HHMI descubren una proteína que detiene el crecimiento del melanoma.
A study that examined the activity of one plant species' 22,000 genes over a complete day and night cycle showed that midnight is a special time that plants can actually distinguish.
HHMI investigators are beginning to examine every gene in the genome to figure out which genes are deleterious to tumor cells.
HHMI has selected five young scientists as recipients of this year's Gilliam Fellowships for Advanced Study.
El HHMI ha seleccionado a cinco científicos jóvenes como destinatarios de las Becas Gilliam para Estudios Avanzados de este año.
Biografías cortas de cada Becario Gilliam de este año.
The birth of new neurons appears to facilitate certain types of complex learning.
Short biographies of each of this year's Gilliam Fellows.
HHMI Trustee was a distinguished public servant, educator and businessman.
HHMI researchers have revealed how a molecule-munching enzyme helps maintains the internal highways found in cells.
The body's immune system can use a surprisingly common molecule to recognize prostate tumors.
Researchers have identified 273 host proteins that serve to keep the AIDS virus healthy and happy as it infects cells.
Researchers have identified small pieces of RNA that suppress the spread of breast cancer to the lungs and bone.
Ambassador Charlene Barshefsky, Senior International Partner at the law firm of WilmerHale in Washington, D.C., has been elected a Trustee.
New research has found that many of the symptoms of fragile X syndrome can be eliminated in mice by reducing the expression of a single gene.
Researchers have a new picture of how neurons forge physical connections between one another in order to communicate.
Even short bursts of activity in a few neurons can influence learning and decision making.
New findings help explain how the brain communicates with the inner ear, reducing its response to sound in loud or distracting environments.
Nuevo descubrimiento ayuda a explicar cómo se comunica el cerebro con el oído interno, reduciendo la respuesta al sonido en ambientes ruidosos o que distraen.
Despite a vast evolutionary gulf, humans and the three-spined stickleback fish have adopted a common genetic strategy to acquire the skin pigmentation that helps them thrive.
A team of researchers has exposed how one of the genes most commonly mutated in human cancers helps good cells go bad.
A pesar de la gran brecha evolutiva que existe entre los seres humanos y el pez espinoso de tres espinas, las dos especies han adoptado una estrategia genética común para adquirir la pigmentación de la piel que ayudaría a estas dos especies a prosperar en su nuevo ambiente.
Equipo de investigadores expone la forma en la que uno de los genes que más comúnmente muta en los cánceres humanos puede hacer que las células buenas se conviertan en malignas.
Twelve colleges and universities have been selected to participate in a nationwide genomics course that will involve first-year college students in authentic research.