A cellular gatekeeper inside a malaria parasite doesn't care whether the amino acid letters on a protein's entry ticket are out of order.
Researchers studying spinocerebellar ataxia have uncovered a pathological mechanism that may also underlie more common neurological diseases.
HHMI announces a major new program that will provide much-needed support to some of the nation's best early career faculty.
View the complete list of eligible institutions.
Metastatic colon cancers carry the ability to metastasize from the time they become cancerous, and don't need to acquire any new genetic mutations to become metastatic.
A fruit fly's misguided neurons provide a fascinating look at the evolution of systems that detect carbon dioxide.
People who lack a certain large segment of DNA have a previously unrecognized syndrome characterized by mental retardation, seizures, and slight physical abnormalities.
HHMI researchers have developed novel techniques and software that will provide scientists with the tools they need to decipher large-scale patterns in the vital - but little-understood - process of DNA methylation.
Investigadores del HHMI han desarrollado técnicas y software nuevos que les proveerán a los científicos de las herramientas necesarias para descifrar patrones de metilación a gran escala en el vital –pero poco entendido– proceso de metilación de ADN.
Malaria-causing parasites evade the immune system by ducking in and out of cells.
Certain regions inside the nucleus can prevent the genes inside them from becoming activated.
HHMI researchers have uncovered a protein that stops the growth of melanoma.
A new microscopy technique allows researchers to examine the complete three-dimensional morphology of many of the tiniest structures of cells.
Investigadores del HHMI descubren una proteína que detiene el crecimiento del melanoma.
A study that examined the activity of one plant species' 22,000 genes over a complete day and night cycle showed that midnight is a special time that plants can actually distinguish.
HHMI investigators are beginning to examine every gene in the genome to figure out which genes are deleterious to tumor cells.
The birth of new neurons appears to facilitate certain types of complex learning.
HHMI researchers have revealed how a molecule-munching enzyme helps maintains the internal highways found in cells.
The body's immune system can use a surprisingly common molecule to recognize prostate tumors.
Researchers have identified 273 host proteins that serve to keep the AIDS virus healthy and happy as it infects cells.
Researchers have identified small pieces of RNA that suppress the spread of breast cancer to the lungs and bone.
New research has found that many of the symptoms of fragile X syndrome can be eliminated in mice by reducing the expression of a single gene.
Researchers have a new picture of how neurons forge physical connections between one another in order to communicate.
Even short bursts of activity in a few neurons can influence learning and decision making.
New findings help explain how the brain communicates with the inner ear, reducing its response to sound in loud or distracting environments.
Nuevo descubrimiento ayuda a explicar cómo se comunica el cerebro con el oído interno, reduciendo la respuesta al sonido en ambientes ruidosos o que distraen.
Despite a vast evolutionary gulf, humans and the three-spined stickleback fish have adopted a common genetic strategy to acquire the skin pigmentation that helps them thrive.
A team of researchers has exposed how one of the genes most commonly mutated in human cancers helps good cells go bad.
A pesar de la gran brecha evolutiva que existe entre los seres humanos y el pez espinoso de tres espinas, las dos especies han adoptado una estrategia genética común para adquirir la pigmentación de la piel que ayudaría a estas dos especies a prosperar en su nuevo ambiente.
Equipo de investigadores expone la forma en la que uno de los genes que más comúnmente muta en los cánceres humanos puede hacer que las células buenas se conviertan en malignas.
New research shows that normal aging appears to disrupt communication between different regions of the brain.
Nueva investigación muestra que el envejecimiento normal parece interrumpir la comunicación entre distintas regiones del cerebro.
The antidepressant mianserin can extend the lifespan of the the roundworm by about 30 percent.
Structural information about the protein the measles virus uses to attach itself to target cells suggests a strategy to fight infection.
HHMI investigator Dorothee Kern and her colleagues have developed a new picture of how the enzyme adenylate cyclase works.
Información estructural sobre la proteína que usa el virus del sarampión para unirse a sus células dianas podría proporcionar una nueva estrategia para luchar contra la infección.
Researchers have deciphered the molecular language that cholera bacteria use to coordinate their infectivity. By interrupting the bacterium's chemical conversation, researchers may be able to stop cholera virulence.
HHMI researchers are unveiling the most detailed views yet of the structure of a voltage-dependent potassium ion channel.
Unos investigadores han descifrado el lenguaje molecular que las bacterias del cólera utilizan para coordinar su infectividad. Al interrumpir la conversación química de las bacterias, se podría detener la virulencia del cólera.
Researchers have developed a small molecule that can turn the survival signal for a variety of cancer cells into a death signal.
New details emerge about how cells decide their fates when faced with stress.
Researchers have devised a new strategy to fight breast and ovarian cancer.
Scientists have shown how odor-sensing neurons in the worm can activate or inhibit other neurons that control crawling and turning.
New studies reveal that the cancer-promoting gene ras relies on 28 other genes to switch off the cell's programmed cell death pathway.
HHMI researchers discover a clever strategy that helps Legionella pneumophila infect host cells.
HHMI researchers have now discovered a protein that can affect how DNA is packaged inside sperm.
A worldwide network of more than 150,000 home computer users helped HHMI researchers predict the structure of a small, naturally occurring protein.
The brain may continue to consider the options even after a decision is made, leaving room for a change of mind.
New study suggests that each breast and colon tumor is unique and may arise through mutations in many different combinations of genes.
HHMI announces the selection of 15 of the nation's top patient-oriented researchers, who will soon become HHMI investigators.
Meet the 15 physician-scientists selected in 2007 as new HHMI investigators.
HHMI investigator Mario R. Capecchi is among trio of scientists honored for development of powerful gene-targeting techniques.
Mario Capecchi received a Kyoto Prize from the Inamori Foundation in 1996. The lecture he delivered when he accepted the prize in Japan in November 1996 tells the story of his remarkable life. The text of the lecture has been edited for length.
New studies establish how the stress hormone norepinephrine boosts learning by strengthening connections between neurons.
Scientists have traced the 170 million-year evolution of a piece of "junk" DNA to its modern incarnation as an important regulator of energy balance.
Científicos rastrean la evolución que tuvo, durante 170 millones de años, un pedazo de ADN “basura” hasta encontrar su encarnación moderna como regulador importante del balance energético.
HHMI researchers have figured out how a bacterial circadian clock ticks away using only three interacting proteins.
Researchers have demonstrated how tens of thousands of closely related proteins establish the specificity that allows them to serve as identification tags for individual neurons.
Researchers have determined the identity of a significant feature that makes a neuron a recycler par excellence.
Scientists have succeeded in reprogramming adult stem cells from the testes of male mice into functional blood vessels and contractile cardiac tissue.
A chemical produced when the body breaks down cholesterol inhibits the activity of estrogens circulating in the blood.
Individual variability in innate immunity may leave some people dangerously exposed to common pathogens such as herpes simplex virus.
A genetic mutation found in some people with autism and Asperger syndrome causes social impairment and cognitive enhancement in mice.
Researchers have provided insight into how mutations in a single gene can cause mental retardation and kidney dysfunction in boys with Lowe syndrome.
Studies reveal why the same prion protein can be either weakly or strongly infectious.
HHMI researchers have identified an "emergency" mechanism that yeast cells use to switch on protein synthesis in times of stress.
A red sea anemone purchased in a Moscow pet shop provides a blueprint for a more vivid red fluorescent protein.
Photosensing proteins drive the spread of a bacterial infection that costs cattle farms in Brazil and Argentina up to $100 million a year.
A systematic strategy may uncover the different developmental steps and cellular machinery used to build axons and dendrites.
Proteínas fotosensibles conducen la diseminación de la brucelosis vacuna, que es una infección bacteriana que le cuesta a las haciendas en Brasil y Argentina hasta $100 millones de dólares por año.
Researchers are learning how the neurons of people with Lafora disease accumulate toxic amounts of carbohydrates.
Investigadores aprenden la forma en la que las neuronas de las personas con la enfermedad de Lafora acumulan cantidades tóxicas de carbohidratos.
In mending the DNA broken during antibody production, immune cells can employ a type of DNA repair that is fundamentally different than the classical method.
HHMI scientists have created a completely new enzyme entirely in vitro.
A colorful new palette of fluorescent tags promises to give researchers a better view of life at the molecular level.
When pathogenic microbes or chemicals inflame the intestine, the balance of microbial power shifts.
A molecule that constantly reinvents itself is one of the many ingenious mechanisms that the malaria parasite has evolved to protect itself against the human immune system.
Mother's milk can turn toxic if the molecular pathways that govern its production are disrupted.
La leche materna puede volverse tóxica si se descomponen las vías moleculares que gobiernan su producción.
Researchers have identified a new mechanism by which tricyclic antidepressants (TCAs) inhibit neurotransmitter transporters.
Scientists uncover significant differences in the mature, functioning neurons generated from two NIH-approved stem cell lines.
Científicos descubren diferencias significativas en neuronas maduras y funcionales generadas a partir de dos líneas de células troncales aprobadas por el NIH.
By short-circuiting the sensory organ that detects the chemical cues mice use to attract mates, researchers have prompted female mice to behave like male mice in the throes of courtship.
Researchers have produced a genetically altered strain of tuberculosis that elicits a stronger immune response than the current vaccine.
A new delivery vehicle for transplanted islet cells may help clinicians track the cells once they are inside the body.
Researchers have discovered a protein that fetal, but not adult, blood-forming stem cells need to replenish themselves.
The traditional prescriptions for a healthy life—sensible diet, exercise and weight control—extend life by reducing signaling through a specific pathway in the brain.
Las recomendaciones tradicionales para tener una vida sana—dieta prudente, ejercicio y control de peso—extienden la vida al reducir la señalización que se lleva a cabo mediante una vía específica del cerebro.
A protein whose function is lost in a broad array of cancers normally suppresses prostate cancer metastasis, researchers have shown in studies with mice.
HHMI researchers have found that insulin resistance in skeletal muscle leads to alterations in energy storage that set the stage for the metabolic syndrome.
A new device may make the most reclusive members of microscopic communities much more accessible for laboratory study.
It can take hours, or even days, for a virus to infect a cell. But poliovirus is more efficient than the average virus.
A new link between inflammation and cancer has revealed how the body's natural response to tissue injury can actually spur tumor growth.
A new study shows how loss of a single enzyme that performs two critical functions can create the potential for cancer when immune cells divide and mature.
Laboratory experiments have enabled researchers to bypass half a billion years of evolution, giving one protein the ability to function like a distantly related protein with just a few simple changes.
Genetic analysis of a year's worth baby poop has given researchers a detailed picture of how bacteria come and go in the intestinal tract.
Scientists have found that they can modify naturally occurring viruses to create targeted weapons against biofilms.
Treating hepatitis B patients with the drug entecavir can cause those who are also infected with HIV to become resistant to two of the most important drugs in the anti-HIV arsenal.
Zebrafish produce natural chemicals that enhance production of blood-forming stem cells.
El tratar a pacientes con hepatitis B usando la droga entecavir puede hacer que quienes también están infectados con el VIH se vuelvan resistentes a dos de las drogas más importantes del arsenal contra el VIH.