Variations in the ways abnormal proteins fit together to form the long amyloid fibrils associated with many diseases may represent a protein-based system of inheritance that parallels the genetic code.
Researchers have identified two molecular keys that help release salts from cells, keeping them alive in the ever-changing salinity of their environment.
Researchers have learned how a molecular switch helps the immune system to keep cancer in check by promoting the destruction of abnormal blood cells.
Interfering with communication among bacteria can prevent them from mounting a unified assault on their host.
A new study shows that most early ovarian tumors exist for years at a size that is a thousand times smaller than existing tests can detect reliably.
Un nuevo estudio muestra que la mayoría de los tumores ováricos en estadios tempranos tienen, durante años, un tamaño que es mil veces más pequeño del que los análisis existentes pueden detectar con confiabilidad.
Tiny, hair-like projections called cilia sense bitter material in the airways and help expel it.
An HHMI-funded graduate student and her colleagues have found that some chimps infected with the primate form of HIV develop AIDS-like symptoms and die early.
New clues narrow the search for the underlying cause of a serious congenital heart defect.
Lung cancer cells hijack a master cellular signal and use it to seed deadly new tumors in the brain, bone marrow, and other organs.
New evidence suggests that damage to nerve cells in people with MS accumulates because the body's mechanism for repairing the nerve coating called myelin stalls out.
Researchers have identified two proteins that begin to explain how radically slashing calories leads to a longer life.
Joan Massagué honored for elucidating one of the fundamental processes that control cell division.
A new method will speed the identification of the targets of microRNAs—the tiny but powerful bits of nucleic acid that tweak gene expression to influence many aspects of health and human disease.
HHMI is expanding collaborations with the Jane Coffin Childs Memorial Fund, the Helen Hay Whitney Foundation, the Damon Runyon Cancer Research Foundation, and the Life Sciences Research Foundation to increase support for outstanding postdoctoral researchers.
New research shows that a father’s sperm passes along a previously unrecognized set of instructions that helps guide the early development of his children.
A new molecular portrait of rotavirus may help researchers design more effective vaccines against the lethal gastrointestinal infection that kills 500,000 children annually.
A new microscopy technique is enabling researchers to capture videos of fast-moving cellular processes with super high resolution.
New research indicates that in most cases, natural selection may shape the human genome much more slowly than previously thought.
HHMI researchers identify many potential new drug targets for cancers long deemed "untouchable."
Research suggests new avenues to treat or prevent infections by parasitic worms.
A protein often accused of sparking autoimmune disease can suppress the onset of inflammatory bowel disease.
HHMI scientists have taken a major step towards understanding the molecular mechanisms that transform Listeria monocytogenes from a harmless soil-dweller to a dangerous human pathogen by mapping the genes that Listeria expresses under different environmental conditions.
Horvitz's election to the Fellowship of the Royal Society recognizes his exceptional contributions to science.
Ultraviolet radiation from the sun can zap DNA, damage cells, and set the stage for the subsequent development of cancer. Scientists have now identified the built-in safety mechanism that forces some cells damaged by UV radiation to commit suicide so they do not perpetuate harmful mutations.