Brief summaries of the research carried out by the 12 patient-oriented researchers selected by HHMI in 2002
HHMI announces new national competition to appoint outstanding physician-scientists as HHMI investigators. The Institute expects to select approximately 15 new researchers by Fall 2007 and is committing approximately $200 million to their first term of appointment.
Researchers have created a map of the protein landscape that regulates a stem cell's ability to differentiate into multiple types of mature cells.
HHMI researchers and their colleagues developed a systematic method for speeding up the crystallization of proteins, an advance that may greatly aid x-ray crystallography.
A new study suggests that human evolution was not just a matter of spontaneous advantageous mutations arising within the human lineage.
HHMI researchers have created a map that helps explain how the brain generates the assortment of specialized proteins it needs to process information.
A newly identified gene mutation helps explain a subset of cases of osteogenesis imperfecta.
By turning on a single gene, researchers can prevent skin stem cells from maturing into the three types of adult skin cells.
Now that clinical trials have shown ranibizumab's "miraculous" effects on patients' eyesight, a crucial next step is to compare ranibizumab to a related drug, which is less than ten times the cost.
HHMI investigator Craig Mello of the University of Massachusetts Medical School and Stanford researcher Andrew Fire honored for discovery of RNA interference.
El investigador del HHMI Craig C. Mello, de la Facultad de Medicina de la Universidad de Massachussets, y el investigador de Stanford, Andrew Fire, fueron honrados por el descubrimiento de la interferencia de ARN.
A structural protein can determine whether an insect develops the highly organized, light-harvesting eye of a fly.
Some infectious diseases might run in families because susceptibility to them is inherited.
An HHMI international research scholar in Israel has discovered one reason why so-called "flesh-eating" bacteria are so hard to stop.
Algunas enfermedades infecciosas podrían presentarse en ciertas familias porque se hereda la susceptibilidad a las mismas.
Un becario internacional de investigación del HHMI en Israel ha descubierto una razón por la que es tan difícil detener a una bacteria llamada “comedora de carne”.
Howard Hughes Medical Institute investigator Jack W. Szostak at Massachusetts General Hospital, Carol W. Greider of Johns Hopkins University and Elizabeth H. Blackburn of the University of California, San Francisco, have been awarded the 2006 Albert Lasker Award for Basic Medical Research.
HHMI researchers have found that a typical breast or colorectal tumor results from mutations in about 90 genes.
A single molecular switch plays a central role in inducing stem cells in the brain, pancreas, and blood to lose function as they age.
A study of sperm formation in worms may point toward a major cause of infertility in humans.
Experimental work has led to the first mathematical model of a regulatory circuit that blood-forming stem cells use to decide what kind of white blood cell they will become.
Research teams have collaborated to identify the cells and receptor responsible for processing sour taste in mammals.
Children with Loeys-Dietz syndrome should be considered early candidates for surgery to prevent lethal rupture of the aorta.
Scientists working at the epicenter of the South African AIDS epidemic have discovered how HIV "exhausts" killer T cells that would otherwise attack the virus.
Científicos que trabajaban en el epicentro de la epidemia del SIDA en Sudáfrica han descubierto cómo el VIH “agota” a las células T asesinas, que de otra manera atacarían al virus.
HHMI scientists discover a human DNA sequence that has evolved rapidly since humans diverged from their closest evolutionary relatives.
Proteins can wreak havoc in the brain even when the genes that encode them are perfectly normal.
New technique images cellular proteins with near-molecular resolution.
A detailed view of a smallpox enzyme opens the way to developing the first drugs against virus.
Using real-time imaging to track malaria infection in live mice, researchers have discovered one of malaria's sneakiest tricks.
Usando procesamiento de imágenes en tiempo real para detectar infecciones palúdicas en ratones vivos, unos investigadores han descubierto uno de los trucos más ocultos del parásito de la malaria.
Scientists have identified a key enzyme that the dengue virus uses to replicate, triggering the potentially fatal dengue hemorrhagic fever.
Científicos identifican una enzima clave que el virus del dengue utiliza para replicarse, lo que activa la potencialmente fatal fiebre hemorrágica del dengue.
A new drug target could defeat HIV's rapid evolution, its main mechanism of drug resistance.
Nuevo blanco de ataque de drogas podría derrotar la rápida evolución del VIH, su mecanismo principal de resistencia a drogas.
Researchers have discovered a critical function for a protein involved in spinal muscular atrophy (SMA), the number one genetic killer of children under the age of two.
New research indicates that drugs that target a cell growth pathway called the JAK-STAT pathway are likely to be effective against certain chronic leukemias.
Researchers analyze proteins to find cancer-causing mutations.
A natural chemical may yield a prime target for novel cholesterol-lowering drugs and the blueprint for a new generation of antibiotics.
A single genetic mutation contributes to a lifesaving color variation in Florida beach mice.
Researchers have identified a protein that could aid development of methods to grow skin to treat patients.
Researchers have greatly shortened the time it takes to create a mouse model of human liver cancer, and used the technology to identify two genes that drive the disease.
HHMI researchers discover that brittle prion particles break into new "seeds," which spread infection quickly.
Defects in a critical cellular pathway can lead to symptoms of Parkinson's disease.
Neurons in the brains of mice sprout robust new connections when the animals adjust to new experiences.
Researchers obtain the first definitive look at how a protein often implicated in cancer development turns itself on to promote cell growth.
An experimental drug reverses the signs and symptoms of patients whose chronic myeloid leukemia has failed to respond to Gleevec.
Certain variants of a simple sugar ameliorate Alzheimer's disease in mice.
A handful of Pittsburgh high school and college students who isolated and characterized 30 new viruses that infect bacteria have co-authored a research article in a peer-reviewed scientific journal.