HHMI researchers map the fine details of the many chromosomal breaks and rearrangements that have reshaped the white-cheeked gibbon's genome.
Adult stem cells call the shots when it comes to their daughters' destinies.
New data suggest that 40-50 percent of human and mouse genes have alternative promoters.
Nuevos datos sugieren que entre el 40 y 50 por ciento de los genes humanos y de ratón tienen promotores alternativos.
Researchers have constructed a protein out of amino acids not found in natural proteins, forming a complex, stable structure that closely resembles a natural protein.
Healthy and viable mice that survive until adulthood have, for the first time, been cloned from adult stem cells.
Por primera, vez ratones sanos y viables que alcanzan la adultez han sido clonados a partir de células troncales adultas.
Precise protein targeting allows cells to build cell-to -cell junctions in the right place.
Changes in an enzyme known to be vital to the body's energy levels may lead to a decreasing ability to stave off diabetes as we get older.
A protein that captures light in ocean-dwelling bacteria puts light's energy to work inside cells.
A drug that keeps blood pressure under control may offer new hope for patients with muscular dystrophy.
HHMI researchers have now found one clue that may tell them why the liver is a master of regeneration.
Investigadores del HHMI han encontrado una pista que podría decirles por qué el hígado es un experto en regeneración.
Researchers have identified a family of proteins that contributes to the survival and regenerative potential of blood-forming stem cells.
Investigadores descubren una familia de proteínas que contribuye a la supervivencia y al potencial regenerador de las células troncales de formación de sangre.
HHMI researchers have reactivated the p53 gene in mice, causing blood, bone and liver tumors to self destruct.
A team led by an HHMI international research scholar has identified a new genetic risk factor associated with the most common form of Alzheimer's disease.
Researchers learn how a set of enzymes contorts itself during the molecular relay race involved in tagging proteins.
Genetically altered mice are helping scientists illuminate the fundamentals of biological clocks.
Researchers have designed a laboratory about the size of a quarter that is capable of conducting thousands of experiments simultaneously.
HHMI scientists are making 'chemical factories' that help laboratory animals produce resveratrol -- the compound behind red wine's frequently touted health benefits.
Scientists can turn on or block regeneration in zebrafish with the flip of a molecular switch.
Researchers have learned how the immune system slices and dices genes so B cells can program antibodies to seek out and destroy invaders.
Two HHMI research teams have discovered new information about how the botulinum neurotoxin shuts down neurons with deadly efficiency.
HHMI researchers discover a line of communication that helps hair follicles organize and align themselves into a well ordered pattern.
Scientists discover a new place to search for the factors that cause neurons to sprout connections.
After five years, some 95 percent of study participants have survived the cancer due to treatment with Gleevec.
P[acman], a new tool for inserting large genes into precise locations on the chromosome, may enable researchers to overcome challenges in pinning down the function of genes.
New research shows that at least 10 percent of genes in the human population can vary in the number of copies of DNA sequences they contain—a finding that alters current thinking that the DNA of any two humans is 99.9 percent identical in content and identity.
Nuevo estudio muestra que al menos el 10 por ciento de los genes de la población humana puede tener un número distinto de copias de secuencias de ADN –descubrimiento que modifica la idea actual de que el ADN de dos seres humanos cualesquiera es un 99.9 por ciento similar en contenido e identidad–.
New findings hint that dendritic spines could make the human brain a far more efficient learning machine than that of other animals.
Analyzing the machinery a roundworm uses to repress genes on an entire chromosome reveals surprising principles about gene regulation.
Here is a list of research institutions that qualify for the 2007 competition.
Brief summaries of the research carried out by the 12 patient-oriented researchers selected by HHMI in 2002
HHMI announces new national competition to appoint outstanding physician-scientists as HHMI investigators. The Institute expects to select approximately 15 new researchers by Fall 2007 and is committing approximately $200 million to their first term of appointment.
Researchers have created a map of the protein landscape that regulates a stem cell's ability to differentiate into multiple types of mature cells.
HHMI researchers and their colleagues developed a systematic method for speeding up the crystallization of proteins, an advance that may greatly aid x-ray crystallography.
A new study suggests that human evolution was not just a matter of spontaneous advantageous mutations arising within the human lineage.
HHMI researchers have created a map that helps explain how the brain generates the assortment of specialized proteins it needs to process information.
A newly identified gene mutation helps explain a subset of cases of osteogenesis imperfecta.
By turning on a single gene, researchers can prevent skin stem cells from maturing into the three types of adult skin cells.
Now that clinical trials have shown ranibizumab's "miraculous" effects on patients' eyesight, a crucial next step is to compare ranibizumab to a related drug, which is less than ten times the cost.
HHMI investigator Craig Mello of the University of Massachusetts Medical School and Stanford researcher Andrew Fire honored for discovery of RNA interference.
El investigador del HHMI Craig C. Mello, de la Facultad de Medicina de la Universidad de Massachussets, y el investigador de Stanford, Andrew Fire, fueron honrados por el descubrimiento de la interferencia de ARN.
A structural protein can determine whether an insect develops the highly organized, light-harvesting eye of a fly.
Some infectious diseases might run in families because susceptibility to them is inherited.
An HHMI international research scholar in Israel has discovered one reason why so-called "flesh-eating" bacteria are so hard to stop.
Algunas enfermedades infecciosas podrían presentarse en ciertas familias porque se hereda la susceptibilidad a las mismas.
Un becario internacional de investigación del HHMI en Israel ha descubierto una razón por la que es tan difícil detener a una bacteria llamada “comedora de carne”.
Howard Hughes Medical Institute investigator Jack W. Szostak at Massachusetts General Hospital, Carol W. Greider of Johns Hopkins University and Elizabeth H. Blackburn of the University of California, San Francisco, have been awarded the 2006 Albert Lasker Award for Basic Medical Research.