Researchers are learning how the neurons of people with Lafora disease accumulate toxic amounts of carbohydrates.
Investigadores aprenden la forma en la que las neuronas de las personas con la enfermedad de Lafora acumulan cantidades tóxicas de carbohidratos.
In mending the DNA broken during antibody production, immune cells can employ a type of DNA repair that is fundamentally different than the classical method.
HHMI scientists have created a completely new enzyme entirely in vitro.
A colorful new palette of fluorescent tags promises to give researchers a better view of life at the molecular level.
When pathogenic microbes or chemicals inflame the intestine, the balance of microbial power shifts.
A molecule that constantly reinvents itself is one of the many ingenious mechanisms that the malaria parasite has evolved to protect itself against the human immune system.
Mother's milk can turn toxic if the molecular pathways that govern its production are disrupted.
La leche materna puede volverse tóxica si se descomponen las vías moleculares que gobiernan su producción.
Researchers have identified a new mechanism by which tricyclic antidepressants (TCAs) inhibit neurotransmitter transporters.
Scientists uncover significant differences in the mature, functioning neurons generated from two NIH-approved stem cell lines.
Científicos descubren diferencias significativas en neuronas maduras y funcionales generadas a partir de dos líneas de células troncales aprobadas por el NIH.
By short-circuiting the sensory organ that detects the chemical cues mice use to attract mates, researchers have prompted female mice to behave like male mice in the throes of courtship.
Researchers have produced a genetically altered strain of tuberculosis that elicits a stronger immune response than the current vaccine.
A new delivery vehicle for transplanted islet cells may help clinicians track the cells once they are inside the body.
Researchers have discovered a protein that fetal, but not adult, blood-forming stem cells need to replenish themselves.
The traditional prescriptions for a healthy life—sensible diet, exercise and weight control—extend life by reducing signaling through a specific pathway in the brain.
Las recomendaciones tradicionales para tener una vida sana—dieta prudente, ejercicio y control de peso—extienden la vida al reducir la señalización que se lleva a cabo mediante una vía específica del cerebro.
A protein whose function is lost in a broad array of cancers normally suppresses prostate cancer metastasis, researchers have shown in studies with mice.
HHMI researchers have found that insulin resistance in skeletal muscle leads to alterations in energy storage that set the stage for the metabolic syndrome.
A new device may make the most reclusive members of microscopic communities much more accessible for laboratory study.
It can take hours, or even days, for a virus to infect a cell. But poliovirus is more efficient than the average virus.
A new link between inflammation and cancer has revealed how the body's natural response to tissue injury can actually spur tumor growth.
A new study shows how loss of a single enzyme that performs two critical functions can create the potential for cancer when immune cells divide and mature.
Laboratory experiments have enabled researchers to bypass half a billion years of evolution, giving one protein the ability to function like a distantly related protein with just a few simple changes.
Genetic analysis of a year's worth baby poop has given researchers a detailed picture of how bacteria come and go in the intestinal tract.
Scientists have found that they can modify naturally occurring viruses to create targeted weapons against biofilms.
Treating hepatitis B patients with the drug entecavir can cause those who are also infected with HIV to become resistant to two of the most important drugs in the anti-HIV arsenal.
Zebrafish produce natural chemicals that enhance production of blood-forming stem cells.
El tratar a pacientes con hepatitis B usando la droga entecavir puede hacer que quienes también están infectados con el VIH se vuelvan resistentes a dos de las drogas más importantes del arsenal contra el VIH.
El descubrimiento de que el pez cebra produce productos químicos naturales que incrementan la producción de células troncales de formación de sangre podría traducirse rápidamente a nuevos tratamientos para aumentar la eficacia de los transplantes humanos de médula ósea o de cordón umbilical.
Identifying the complete set of genes whose activity is altered by disease used to appear impossible. Not anymore.
Una mutación en un único gen puede hacer que muchos otros genes comiencen a funcionar—o dejen de hacerlo—, y puede ser que estos cambios causen en última instancia síntomas clínicos. La identificación del conjunto completo de genes afectados parecía imposible. Pero ese ya no es el caso.
An HHMI professor has teamed up with the Posse Foundation to develop a bold plan to equip inner-city high school students to succeed in the sciences.
HHMI scientists have discovered that microRNAs can also shut down the proliferation of cancer cells.
Científicos descubren que fascinantes trocitos de material genético conocidos como microARNs también pueden detener la proliferación de células cancerígenas.
Researchers have identified a master hormone that allows the body to fuel itself with stored fat during times of fasting.
Researchers have measured the electrical activity at play in brain cells as animals make a choice based on their interpretation of a set of visual cues.
Investigadores han medido la actividad eléctrica de células cerebrales cuando los animales realizan una elección basándose en la interpretación de un conjunto de señales visuales.
Researchers have identified a new population of stem cells that act to repair muscle after damage.
Studies in mice show that lithium can ease the symptoms of spinocerebellar ataxia type 1, an inherited neurodegenerative disorder.
A new database created by HHMI researchers reveals a 700-member strong army of proteins involved in the DNA repair response.
Researchers have found that neural activities in the brain gradually change, even when nothing new is being learned.
A new kind of test tube is revolutionizing the way researchers observe the behavior of single molecules of DNA, RNA, or proteins.
New evidence shows that Wilms tumor—a rare kidney cancer that affects children—promotes its own growth agenda by taking over a genetic program used by normal cells during development.
A major new research effort is now beginning to uncover the structural variations in DNA that contribute to genetic differences between humans.
Researchers have identified small regions within a yeast protein that control the protein's conversion to an infectious agent known as a prion.
Un nuevo e importante trabajo está comenzando a descubrir diferencias estructurales en el ADN que generan diferencias genéticas entre los humanos.
Researchers have found that a much-studied gene provides branches of nerve cells the ability to recognize one another and grow apart, helping them cover as much space as they can evenly and efficiently.
Mice whose brains had lost a large number of neurons regained long-term memories and the ability to learn after their surroundings were enriched with toys and other sensory stimuli.