A new technique factors a protein's flexibility into the drug design equation. It's paying off in a big way.
New technology makes it possible to study tissue samples locked away for decades.
Nueva tecnología hace posible el estudio de muestras de tejidos guardadas por décadas.
New studies show how the brain changes when mice learn to feel safe and secure in situations that would normally make them anxious.
Roger Tsien, Osamu Shimomura, and Martin Chalfie honored for the discovery and development of the green fluorescent protein, a ubiquitous research tool.
Roger Tsien, Osamu Shimomura and Martin Chalfie son galardonados por el descubrimiento y desarrollo de la proteína fluorescente verde, que es una herramienta general de investigación.
HHMI researchers devise prenatal blood test that accurately detects Down syndrome and two other serious chromosomal defects.
Investigadores del HHMI desarrollan un nuevo análisis de sangre prenatal que detecta con precisión el síndrome de Down y otros dos defectos cromosómicos serios.
HHMI researchers have found microRNAs in animal species whose last common ancestors were present on Earth about 1 billion years ago.
HHMI researchers have developed a new model of cystic fibrosis in pigs that more accurately mimics features of the disease.
Investigadores del HHMI han desarrollado un nuevo modelo de fibrosis quística en cerdos que imita de forma más precisa las características de la enfermedad que se observa en infantes humanos.
Researchers have identified a gene from a new family of ion channels that help to regulate smell and taste sensing, smooth muscle contraction, and fluid secretion in glands and airways.
A newly identified "hot line" connects a worm's nervous system to its immune system.
Investigadores han descubierto una “línea directa” de comunicación que le permite al sistema nervioso de un gusano llamar al sistema inmune para coordinar la respuesta a patógenos infecciosos.
Researchers have learned how Listeria crosses the placenta from mother to baby.
Researchers have devised clever techniques to visualize gene silencing in its natural context.
A gene deletion caused mice to exhibit behavioral and brain changes common in people with Alzheimer's disease or dementia.
Researchers may be able to fight malaria by targeting human liver cells instead of parasites
Las drogas contra la malaria existentes atacan al parásito que causa la enfermedad, pero están perdiendo eficacia debido al aumento en la resistencia a drogas. Investigadores del Instituto Médico Howard Hughes informan que podrían ser capaces de combatir la malaria atacando células humanas hepáticas en lugar de a los parásitos.
A immunosuppressant drug may unexpectedly fight the parasite-caused disease.
Scientists have detected a multitude of broken, missing, and overactive genes in the most detailed genetic survey yet of any human tumor.
Mediante el examen genético más detallado de cualquier tumor humano que se haya realizado hasta el momento, científicos encuentran que en tumores pancreáticos y cerebrales una variedad de genes están rotos, hiperactivos o desaparecen.
Researchers have generated insulin-producing beta cells from adult pancreatic cells in living mice.
Investigadores del HHMI han transformado células pancreáticas adultas en células betas productoras de insulina en ratones vivos.
Researchers have begun scouring cancer cells for potential sites of resistance against a new class of drugs.
Researchers have shown that bacterial communication can be intercepted and chemically manipulated to control group behavior, such as virulence or the production of a useful products.
Researchers have converted cells from individuals with ten different diseases, including muscular dystrophy, juvenile diabetes, and Parkinson's disease, into stem cells.
Scientists have identified more than 300 human genes that influence West Nile virus infection. More than 20 of these cooperate with the virus, whereas the others help cells resist it.
Researchers have used new technology to pinpoint a critical gene mutation in worms in only a few weeks. It would have taken years for scientists using older technology to sift through the worm's DNA until they found the proverbial needle in the haystack.
Researchers have identified a genetic defect that makes some children susceptible to attack by a certain type of bacteria, a finding that will speed up diagnosis and treatment.
Investigadores del HHMI han identificado dos drogas que imitan muchos de los efectos fisiológicos del ejercicio.
HHMI researchers have identified two drugs that mimic many of the physiological effects of exercise.
Researchers have revealed an important step in the process that guides neurons as they establish precise connections between the spinal cord and muscles.
An international team of researchers has identified a gene mutated in Duane syndrome, a common disorder that restricts the movement of the eyes.
Thanks to a set of fruit flies that seem to get by with far less dozing than most, researchers has found a gene absolutely necessary for snoozing.
By focusing on large families in which both parents share a recent ancestor, scientists have honed in on rare mutations that had remained elusive in previous studies.
HHMI-supported scientists have created MitoCarta, an online atlas of more than 1,000 proteins that healthy mitochondria use to keep cells running smoothly—a tool that should help researchers understand what happens when things go wrong.
HHMI international scholar Alan Cowman has set out to understand the proteins that oversee malaria's destruction and rebuilding of red blood cells.
Scientists may be able to stave off influenza infection by targeting one of more than 100 proteins inside host cells on which the virus depends.
New research has uncovered the mechanism that guides vertebral development in the early embryo.
HHMI researchers have developed a mouse model of osteosarcoma, the most common form of bone cancer.
A new model reveals that three classes of HIV drugs inhibit the virus more than 10,000 times better than others
Nuevo modelo matemático revela que tres clases de drogas contra el VIH inhiben al virus 10.000 veces mejor que otras.
Researchers have identified a chemical messenger that helps different sites on individual neurons coordinate with one another.
Scientists have demonstrated how protocells might have taken up nutrients from the earth's early environment to propel their growth.
Scientists have discovered that the mutation that causes Rett syndrome interferes with the regulation of 2,500 other genes.
A protein previously thought to identify only colon cancer stem cells is actually prevalent throughout primary colon tumors.
A prominent protein on the surface of liver cells protects organisms during sepsis, one of the most common and deadly side effects of bacterial infection.
HHMI researchers bring the arcane world of protein folding to the online gaming arena with the launch of "Foldit."
Investigadores del HHMI acercan el arcano mundo del plegamiento proteico al terreno de juegos en Internet con el lanzamiento de “Pliégalo”.