The discovery of an odd couple of genes that team up to trigger rare and difficult-to-detect gastrointestinal stromal tumors could eventually lead to better diagnostics and treatments.
Researchers are inching their way toward a new HIV vaccine strategy by studying the cells of people who have naturally strong immune defenses against the virus.
HHMI and the Gordon and Betty Moore Foundation announce a new partnership to support some of the nation's most innovative plant scientists.
Jeffrey Friedman and Douglas Coleman are being honored for discoveries that led to the identification of leptin, a hormone that regulates appetite and body weight.
Mutations that supercharge a cellular garbage disposal may explain why cancer cells can thrive even as their genetic material multiplies out of control.
A targeted search combined with today's rapid DNA sequencing technology leads researchers to a genetic culprit for a rare disease.
Researchers have new details of how an enzyme helps bacteria slice up foreign genetic material.
Most of the clear cell ovarian carcinoma samples examined in a new study carried a gene mutation that alters the epigenetics of cells.
HHMI researchers have found that malaria parasites can produce multiple versions of a protein that causes infected blood cells to grab onto the inner wall of blood vessels.
Multiple jury prizes were awarded in recognition of contributions advancing technology to automate an important but tedious component of neuroscience research.
If Howard Chang has his way, there will soon be an iPhone app for dialing in RNA structures.
A handful of antibiotic-resistant bacteria can protect an entire colony.
A rare skin disease provides the first example of a disease-causing mutation that spontaneously reverts, producing healthy skin.
With the help of yeast and fruit flies, researchers have identified a distorted gene that appears to be among the most common genetic risk factors for amyotrophic laterial sclerosis (ALS), the devastating neurodegenerative disease also known as Lou Gehrig's disease.
Health officials have held off from recommending an inexpensive malaria drug for widespread use because of concerns about drug resistance. New research drawn from 10 years of field and laboratory studies suggests the drug may be a safe and effective way to prevent malaria.
HHMI researchers develop tiny life-support packets for therapeutic cells.
A cooperative online game has attracted 50,000 players whose “distributed thinking” has, in some cases, proven more powerful than computers in predicting the structure of proteins.
HHMI has awarded $364,000 to more than double the capacity of a vital repository that is a resource for the worldwide community of scientists who study the fruit fly.
A type of prostate cell that has been largely ignored by cancer researchers can trigger malignant prostate cancer.
Janelia Farm researchers show it takes steady hands to measure the brain activity of a fruit fly while it is walking.
HHMI researchers discover that induced pluripotent stem cells retain a genetic memory of their tissue of origin.
A protein that is already the target of experimental drugs that aim to extend life is now known to play a key role in learning and memory.
An ambitious new analysis in mice demonstrates that for more than 1,300 genes active in the brain, there is a significant bias as to which copy is active—the one inherited from the mother or the one that came from the father.
Researchers have identified signaling pathways by which the normal prion protein switches on the general protein synthesis necessary to promote the growth and development of brain cells.
A new imaging method will allow researchers to study speedy cell processes over hours and days rather than seconds, and to examine how morphological defects arise in developing animals.
Five teams will compete in the final round of an international scientific challenge designed to speed development of new computational tools to accurately and automatically reconstruct the shape of brain cells.
Babies delivered via Cesarean section harbor a different ecosystem of bacteria than babies born vaginally.
Jumping genes, thought to have settled down over millions of years of evolution, may be an ongoing source of genetic variation between individuals.
Moore, COO of HHMI's Janelia Farm Research Campus, will assume the new role in September 2010.
Elementary students get a hands-on—and feet-in—experience that teaches them to develop hypotheses and reach conclusions about the relative health of their community stream.
This year, 116 medical, dental, and veterinary students from 47 schools across the country will take a break from memorizing molecular metabolism and studying drug interactions to spend a year in a lab doing hands-on research.
The mucosal immune system is often the first to tangle with microbial invaders. To better understand it, scientists should focus on the interplay between the mucosal immune system and friendly microbes.
HHMI investigator William Newsome and NYU researcher J. Anthony Movshon are recipients of the 2010 Vision Award.
Schmoke, Dean of the Howard University School of Law, succeeds Hanna H. Gray as Chairman of the Trustees of the Howard Hughes Medical Institute.
Researchers have identified a set of hybrid genes that may accelerate the growth of prostate cancer, gastric cancer, and melanoma.
The prestigious $500,000 Lemelson-MIT Prize honors outstanding mid-career inventors dedicated to improving the world through technological invention and innovation.
A pediatric kidney cancer called Wilms tumor may, with just a few genetic changes, hijack pathways that ordinarily drive development of normal kidney tissue.
HHMI researcher Thomas C. Sudhof shares the 2010 Kavli Prize in Neuroscience with Richard H. Scheller and James E. Rothman.
A new genetic analysis suggests that the strains of influenza circulating in the United States can migrate to the rest of the world.
HHMI and the University of KwaZulu-Natal announce appointment of Bishai as the first permanent director of the KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH).
A mysterious swallowing disorder bears similarities to a disease that afflicts parrots and other exotic birds.
A genome-wide search reveals a genetic survival pathway that is switched on in many of the most aggressive glioblastomas.
A unique analysis of environmental contributors to type 2 diabetes has confirmed a link between several pollutants and the disease, while also pointing toward a form of vitamin E as a possible risk factor.
Thirteen HHMI professors with successful science education programs were awarded a total of $9 million over the next four years.
MIT will use part of its $1.8 million HHMI grant to share its online science educational tools with a larger worldwide audience through its OpenCourseWare (OCW) program.
The University of North Texas will use a portion of its first $1.3 million HHMI grant to encourage a successful transition for students from community colleges to the four-year school and expand research opportunities to more students.
The University of Miami is using a portion of its new $1.4 million HHMI grant to spearhead an approach that focuses on preparing undergraduate students from underrepresented backgrounds to succeed in science.
The Science Literacy Program (SLP), funded by an HHMI grant, will help faculty from four departments—chemistry, physics, biology, and geological sciences—transform the classes they offer to non-science majors.
Lehigh's Biosystems Dynamics Summer Institute (BDSI)—a 10-week summer program—places undergraduates, graduate students, and faculty members on interdisciplinary teams to tackle projects such as looking for drugs to treat stress disorders and developing reliable methods to separate cells in the blood for detection of HIV.
High school students across New Mexico have conducted basic genetics experiments with the help of New Mexico State University scientists and a mobile lab that travels to a different high school each week.