Short strands of piwi-interacting RNA may detect foreign invaders by determining whether a gene has ever been turned on in an organism's past.
Quake is being recognized for his work in drug discovery, genome analysis and personalized medicine.
A new imaging technology developed at Janelia lets users track each cell in an embryo as it takes shape over hours or days.
Thirty years after their discovery, scientists have the first picture of a Wnt protein, a member of a protein family that includes some of the most important regulators of growth and development.
HHMI scientists have determined the three-dimensional structure of two proteins that help keep the bodys clocks in sync.
The three scientists are recognized for elucidating basic neuronal mechanisms underlying perception and decision.
Arthur Horwich and Franz-Ulrich Hartl honored for contributions to the understanding of the molecular mechanism of protein folding.
Using genetic programming, researchers have identified a specific type of cell in the outer layers of the brain that is crucial for Prozac's action.
A list of the 47 small colleges and universities awarded a four-year grant in HHMI's science education initiative.
Colleges receive funds to incubate new science education courses and programs.
Seventy students from 27 medical schools across the country will participate in HHMI's year-long Medical Research Fellows Program.
Researchers lay out evidence for how an unusually efficient enzyme evolved from non-catalytic ancestor proteins.
In the region of the brain that controls motor planning, a self-reinforcing loop of neuronal signaling helps establish connectivity during early development.
Researchers have uncovered the enzyme that transfers phosphate to milk proteins like casein, but also to proteins found in bones and teeth enamel.
Dixon, who has led HHMI's scientific programs since 2007, will retire from the Institute in summer 2013.
Fourteen HHMI scientists are among 84 newly elected members.
Bonnie Bassler and Jack Dixon are among eight newly elected foreign members.
Nine HHMI investigators and one HHMI Professor are elected to the American Academy of Arts and Sciences.
The May 9th lecture, Shining Light on How the Brain Works, is free, but tickets are required for admission.
Many of the most severe mutations identified in patients with autism affected proteins that work together in one large interconnected network.
As fish in different parts of the world adapted to live in fresh water, the same sites in the genome were changed time and again.
HHMI researchers Thomas M. Jessell and Michael Rosbash honored for significant contributions to medical science.
HHMI seeks to appoint up to 30 new HHMI investigators in 2013. Applications open on March 15, 2012.
Long, ropy fibers were long thought to be the causes of these diseases including Alzheimer's and Parkinsons, but research over the past decade has revealed that fibers arent amyloid proteins' most toxic form.
In a mouse model of Alzheimer’s disease, an overactive enzyme causes memory problems by shutting off genes related to neuronal communication.
The Gilliam program aims to increase the diversity of college and university faculty by supporting future scientific leaders during their graduate studies.
Defectos en el gen que codifica para la proteína más grande del cuerpo humano son responsables de más casos de la enfermedad que los causados por todas las otras mutaciones conocidas.
Defects in the gene that encodes the human body’s largest protein are responsible for more cases of dilated cardiomyopathy than are caused by all other known mutations associated with the heart disorder.
HHMI researcher and colleagues design and develop drug that prolongs survival in men with advanced prostate cancer.
Investigador del HHMI y sus colegas diseñan y desarrollan una droga que prolonga la supervivencia de hombres con cáncer de próstata avanzado.
HHMI investigator Brian Druker honored for role in developing new cancer drug.
Meet the 2012 International Early Career Scientists
Top biomedical scientists from 12 countries will receive an important boost at a critical time in their careers from HHMI’s inaugural International Early Career Scientist awards.
Perlmutter's lecture on “Building Better Medicines: Drug Discovery in the 21st Century” will take place on February 15.
A breakdown of cellular junk may explain how exercise fends off metabolic disorders and protects against other diseases.
Researchers have discovered a molecular master switch that triggers the genetic overhaul plants need to fight off pathogens.
The gene mutation that causes retinoblastoma changes the way cells turn on and off many other genes.
Researchers have discovered how plants regulate the development of the pores through which critical exchanges of water and carbon dioxide occur.
By resurrecting the ancient forms of a molecular machine, scientists have learned how simple evolutionary processes can produce the complex assemblies of molecules that allow modern cells to function.
New research shows that fluoride has dramatic effects on bacteria inside the mouth.
Sean B. Carroll, HHMI’s vice president for science education and a long-time HHMI investigator, has been awarded the 2012 Benjamin Franklin Medal in Life Science.
Scientists have pinpointed the gene responsible for a disease that causes seizures in infancy and sudden, uncontrollable movements in adolescence and early adulthood.
Studies of fragile X syndrome and tuberous sclerosis show that for brain cells to function normally, neural synapses must produce just the right amount of protein.
By activating regions of the brain linked to food-related pleasure, scientists are learning how the brain mediates the link between food preferences and hunger.
A group of internationally recognized scientists was named to the editorial team of eLife, the new open-access journal to be launched by HHMI, Wellcome Trust and Max Planck Society.
Blood vessels in the lungs produce signals that activate the regeneration of alveoli—the tiny cavities through which blood takes in oxygen and releases carbon dioxide.
The fruit-fly protein Zelda helps govern the developmental handoff from mother's influence to an animal's own genome.
Fruit flies integrate smell and visual information to fine-tune flying behavior.
Seven HHMI investigators are among the 65 new members announced today.
At least 100 trillion bacteria live in the mammalian gut. How can we carry all those organisms and not get sick?