Small genomes are cheaper to sequence and lack the repetitive "junk" that clutters bigger genomes—but a new study suggests that bigger genomes are better for figuring out how genes are controlled.
Researchers have taken a major step toward developing a better animal model of human AIDS by genetically modifying HIV so that it can infect a species of rhesus monkeys.
Scientists have mapped previously unknown pathways in yeast cells that link the overactivity of a mysterious gene to the death of nerve cells in Parkinson's disease.
A new tool reveals the identity and quantity of every protein produced by a living cell at any given time.
Researchers have identified a marker present in the urine of patients with prostate cancer that indicates whether the cancer is progressing and spreading.
Investigadores han identificado un nuevo marcador biológico que se encuentra presente en la orina de pacientes con cáncer de próstata que indica si el cáncer está progresando y se está diseminando.
HHMI researchers and their colleagues unveil the first comparative map of four primate genomes.
Blood platelets can destroy deadly malaria parasites. But a single dose of aspirin may be enough to thwart their killing power.
Nuevos estudios en ratones sugieren que las plaquetas sanguíneas pueden destruir los mortales parásitos de la malaria. Pero una única dosis de aspirina puede interferir con las plaquetas de forma suficiente como para impedir su poder letal.
The shapes of some of the tiniest cellular structures are coming into sharper focus at Janelia Farm, where scientists have developed a new imaging technology that produces the best three-dimensional resolution ever seen with an optical microscope.
Rajesh Gokhale has created a compound in his lab in India that stops tuberculosis by hitting four of the bacterium's crucial metabolic pathways at the same time.
Researchers have discovered a new form of cellular memory that appears to help immune cells "learn" from past encounters with pathogens so they can combat them more effectively the second time around.
Researchers have created an efficient way to detect genes that have been inappropriately fused together, a type of genetic abnormality that spurs the growth of blood and prostate cancers.
A novel kind of odor-detecting protein may explain some of the gaps in researchers' knowledge of how insects smell.
Una nueva clase de proteínas de detección de olores puede explicar algunas de las lagunas en el conocimiento que tienen los investigadores sobre cómo los insectos detectan los olores.
HHMI researchers track down the genes responsible for establishing the characteristic swirl of a snail shells.
A new microscopy technique that uses the principles underlying holography is helping researchers speed up imaging and optically manipulate living cells.
New ways of imaging sugar molecules are creating a vibrant new biological frontier.
A 20 year search has helped international research scholar Hugo D. Luján explain how the Giardia parasite hides from the immune system.
Al igual que una pandilla de bandidos que se cambia la ropa después de un robo para evitar ser capturados, el parásito intestinal Giardia lamblia altera su aspecto para engañar al sistema inmune humano. Después de una búsqueda de 20 años, experimentos realizados por el Becario Internacional de Investigación del Instituto Médico Howard Hughes, Hugo D. Luján, revelan cómo cambia sus disfraces el parásito.
Starved cone cells in the eye may nibble themselves to death in people with retinitis pigmentosa.
Una de las razones por las que mueren las células responsables de la visión de los colores en personas con retinitis pigmentosa puede ser que las células se comen a sí mismas cuando son privadas de nutrientes.
At least one of every four melanoma cells has the capacity to seed the development of new tumors.
By manipulating a newly identified regulatory protein, researchers can reactivate a dormant fetal hemoglobin gene--possibly with therapeutic benefits for patients with life-threatening anemias.
Scientists have created a new mouse model that may help explain how a rare disease causes otherwise supple soft tissue and joints to turn into bone.
HHMI researchers have uncovered a molecular explanation for the profound fatigue brought on by mild exercise in some people with muscular dystrophy.
Researchers have identified a molecule that tells your brain when it's time to say no to a second piece of pie and push back from the Thanksgiving table.
Investigadores identifican una molécula que le dice al cerebro que ha llegado el momento de decirle no a un segundo pedazo pastel de calabaza y alejarse de la mesa del Día de Acción de Gracias.
Susan Lindquist believes that if “personalized medicine” for complex neurodegenerative disorders is to become a reality then scientists must begin developing more rigorous approaches to identifying and validating promising new therapies.
Images in biology textbooks may give the misleading impression that the cell membrane is a passive envelope that does little more than keep the cell’s internal contents in place. Howard Hughes Medical Institute researcher Douglas C. Rees prefers to think of the outer membrane of human cells as a dynamic boundary that sends and receives vital information about the state of affairs inside and outside the cell.
Ants first marched into Danny Reinberg’s world about four years ago as he began thinking about taking his lab in a new direction. Now, he cannot keep ants off his mind because they are the focal point of a newly funded HHMI Collaborative Innovation Award to study whether epigenetics influences the behavior and aging of ants.
In mammals, cells carry out their work driven by two copies of nearly every gene, one inherited from each parent. If something happens to one gene, the other is usually there to compensate. But for a small number of genes, the two copies rule does not apply. For those genes, only one parent’s copy is turned on,and the other is shut off. This regulatory process leaves little room for error because there is no gene to act as a backup if problems arise.
Nearly 70 million people worldwide have glaucoma, an insidious group of diseases that damages the optic nerve and leads to vision loss and blindness. High intraocular pressure, which damages nerve cells in the eye, is one of the biggest known contributing factors in the development of glaucoma.
HHMI broadens its research support with the announcement of a new program to foster collaboration and innovation.
HHMI announces the names of scientists selected to pilot a new program devoted to supporting transformative, collaborative research.
Researchers have traced the sequence of metabolic events that kill E. coli bacteria when they are treated with the antibiotic gentamicin.
New images from HHMI scientists show the stunning dynamics of HIV reverse transcriptase zooming around on the very DNA it is building.
A tiny RNA switch may play a big role in the spread of prostate cancer.
Researchers have discovered three genetic factors that could help doctors identify people who are at the greatest risk for developing a brain aneurysm.
Al escudriñar los genomas de más de 10.000 personas, unos investigadores han descubierto tres factores genéticos que podrían ayudar a que los doctores identifiquen las personas que tienen el mayor riesgo de desarrollar una aneurisma cerebral.
Researchers have developed a method for systematically screening cancer cells to detect genes likely to suppress metastasis.
Researchers have identified the chief motor protein that hauls the building materials needed for learning to their destinations inside neurons.
A new technique factors a protein's flexibility into the drug design equation. It's paying off in a big way.
New technology makes it possible to study tissue samples locked away for decades.
Nueva tecnología hace posible el estudio de muestras de tejidos guardadas por décadas.
New studies show how the brain changes when mice learn to feel safe and secure in situations that would normally make them anxious.
Roger Tsien, Osamu Shimomura, and Martin Chalfie honored for the discovery and development of the green fluorescent protein, a ubiquitous research tool.