Scientists have identified the genetic cause of a rare eye movement disorder and found that specific mutations in the disease gene can cause additional errors in neurodevelopment and neuronal survival.
A newly identified enzyme could help scientists create stem cells and arrest the growth of cancers by giving them the ability to wipe clean cells' developmental slates.
Terrible and swift as anthrax appears to its victims, the deadly toxin takes its time breaking into their cells. The entry of anthrax toxin into its cellular target is part of a carefully-planned, two-pronged attack, scientists have found.
Gerald M. Rubin, director of the Howard Hughes Medical Institute’s Janelia Farm Research Campus, will deliver a public lecture titled “The Fly Brain and Yours—Closer Than You Think,” at Janelia Farm in Ashburn, VA.
Janelia scientists have borrowed a technique from the field of astronomy to overcome biology’s equivalent of the twinkling of stars and the shimmering mirages in desert landscapes.
A small but aggressive fraction of metastatic cancer cells can re-infiltrate the original tumor, boosting its malignant potential.
Una fracción pequeña pero agresiva de células cancerígenas puede reinfiltrar el tumor original, aumentando su potencial maligno.
From the brain's point of view, not every itch is the same. HHMI researchers have identified a new type of itch receptor.
In a tour-de-force of evolutionary sleuthing, researchers have traced a yellow-to-black color change in African fruit flies to five single-letter genetic mutations.
Researchers have identified a naturally occurring human protein that helps prevent infection by H1N1 influenza and other viruses, including West Nile and dengue virus.
A newly identified gene mutation is one of only a handful of mutations outside the X chromosome to be linked to intellectual disability.
A new method for strengthening proteins could lead to improved laundry soap, better nanotechnology, and less expensive cancer drugs.
Comparing the DNA of fish with and without spiny pelvic hindfins provides evidence that evolution can leap rather than shuffle.
Using advanced electron-microscopy and modeling techniques, a team of researchers has determined the structure of a eukaryotic ribosome with unprecedented accuracy.
Scientists have discovered a new type of stem cell in the skin that acts surprisingly like certain stem cells found in embryos: both can generate fat, bone, cartilage, and even nerve cells. These newly-described dermal stem cells may one day prove useful for treating neurological disorders and persistent wounds, such as diabetic ulcers.
HHMI researchers have identified a new factor necessary for the development of medulloblastomas, the most common type of malignant childhood brain cancer.
A protein found in the saliva of ticks may prove to be an attractive target for a new type of Lyme disease vaccine.
Scientists have found that preeclampsia can dramatically increase the likelihood that a woman will experience low thyroid function later in life.
Researchers have developed a new imaging method to track how a person’s brain divides up duties between the two halves.
A new imaging tool lets researchers watch individual neurons in the brains of living animals light up as they work together to control the animal’s behavior.
Scientists have an ambitious new strategy for untangling the evolutionary history of humans and their biological relatives: obtain, preserve, and sequence the DNA of approximately one species for each genus of living mammals, birds, reptiles, amphibians, and fish.
Variations from DNA's iconic double-helix shape transmit information about where proteins need to bind to make sure the right genes are activated or silenced during development.
New research shows that histones that escape from cells aren’t just a byproduct of sepsis, they’re a ringleader in its development.
Cutting down the amount of fat particles in cells may be an effective way to prevent the dengue fever virus from replicating and spreading.
Nueva investigación muestra que el reducir la cantidad de partículas grasas de las células podría ser una forma eficaz de evitar que el virus de la fiebre del dengue se replique y disemine.
A signaling pathway that guides the early development of animals from flies to humans also helps a regenerating flatworm orient itself from head to tail.
José A. Rodriguez, estudiante doctoral financiado por el HHMI en la Universidad de California en Los Ángeles y un equipo multidisciplinario de colegas han encontrado que el parásito Trypanasoma brucei, que causa la enfermedad africana del sueño, no se mueve en sólo una dirección como un sacacorchos.
New research by an HHMI-funded graduate students and his colleagues has overturned an 150-year-old idea of how the parasite Trypanasoma brucei moves. T. brucei causes African sleeping sickness.
Por primera vez, científicos han diagnosticado una enfermedad genética secuenciando completamente todos los genes de un paciente.
For the first time, scientists have diagnosed a genetic disease by completely sequencing all of a patient’s genes.
New research shows how the taste of carbonation is perceived.
New research shows that a protein that stabilizes DNA does a lot of slipping and sliding as it wrestles the molecule into place.
Thomas A. Steitz, Venkatraman Ramakrishnan y Ada E. Yonath son los galardonados con el Premio Nobel de Química de 2009 por sus estudios sobre la estructura y función del ribosoma.
Thomas A. Steitz, Venkatraman Ramakrishnan, and Ada E. Yonath awarded the 2009 Nobel Prize in Chemistry for studies of the structure and function of the ribosome.
HHMI researcher Jack Szostak wins 2009 Nobel Prize in Physiology or Medicine.
La Real Academia de Ciencias Sueca anunció que Jack W. Szostak, Elizabeth Blackburn y Carol Greider fueron galardonados con el Premio Nobel 2009 de Fisiología o Medicina el descubrimiento de cómo los cromosomas son protegidos por los telómeros y la enzima telomerasa.
A study examining the letters of 16 well known writers, performers, politicians, and scientists shows that the factors that determined their correspondence patterns are the same factors that shape emailing patterns today.
In evolution, proteins can’t go home again—at least not by their original route.
A new method for rapidly identifying genes that are crucial for survival of bacteria cuts the time it takes to pinpoint promising new drug targets from years to weeks.
En el mundo de aminoácidos que en su mayoría es “izquierdo”, las versiones “derechas” de algunas de estas moléculas actúan como señales que pueden estimular la adaptación de las bacterias a cambios en las condiciones ambientales.
In the overwhelmingly left-handed world of amino acids, the right-handed versions of a few such molecules act as signals that spur bacteria to adapt to changing conditions.
HHMI investigators Brian Druker and Charles Sawyers will join Nicholas Lydon, formerly of Novartis, in receiving the 2009 Lasker~Debakey Clinical Medical Research Award.
A new genetically encoded switch lets researchers use light to control a cell’s shape and movement.
The sentinels of the immune system possess a hidden strength that may be used to improve vaccine design for tough-to-beat bugs.
The method Google uses to rank the importance of web pages can help identify the species whose extinction would most likely trigger an ecosystem’s collapse.
A new imaging technique will allow scientists to focus on the tiny structures that mediate communication between neurons within relatively intact samples of brain tissue.
Variations in the ways abnormal proteins fit together to form the long amyloid fibrils associated with many diseases may represent a protein-based system of inheritance that parallels the genetic code.
Researchers have identified two molecular keys that help release salts from cells, keeping them alive in the ever-changing salinity of their environment.
Researchers have learned how a molecular switch helps the immune system to keep cancer in check by promoting the destruction of abnormal blood cells.
Interfering with communication among bacteria can prevent them from mounting a unified assault on their host.