A pediatric kidney cancer called Wilms tumor may, with just a few genetic changes, hijack pathways that ordinarily drive development of normal kidney tissue.
HHMI researcher Thomas C. Sudhof shares the 2010 Kavli Prize in Neuroscience with Richard H. Scheller and James E. Rothman.
A new genetic analysis suggests that the strains of influenza circulating in the United States can migrate to the rest of the world.
A mysterious swallowing disorder bears similarities to a disease that afflicts parrots and other exotic birds.
A genome-wide search reveals a genetic survival pathway that is switched on in many of the most aggressive glioblastomas.
A unique analysis of environmental contributors to type 2 diabetes has confirmed a link between several pollutants and the disease, while also pointing toward a form of vitamin E as a possible risk factor.
A groundbreaking comparison of human and Neandertal genomes reveals astonishingly few differences in the DNA that codes for proteins.
Scientists have new clues about what makes some people's immune systems better equipped to control HIV.
In a new study investigating just how pervasive a fruit fly’s sexual identity actually is, researchers find that most cells in flies’ bodies are identical, regardless of whether they are in a male or a female.
El parásito intestinal Giardia lamblia cambia de vestimenta casi tan frecuentemente como una modelo en una pasarela parisina, pero su amplio guardarropa de proteínas superficiales podría en realidad ser su propia perdición. Parásitos Giardia diseñados para que expresen todas sus proteínas de superficie se comportaron como vacunas que podrían ayudar a prevenir o a atenuar futuras infecciones intestinales.
A Giardia parasite engineered to express its extensive wardrobe of surface proteins worked as a vaccine that could help prevent or mitigate future intestinal infections.
By switching off a single gene, researchers have created mice that behave much like people with obsessive-compulsive disorder. The animal model could help scientists design new therapies for the debilitating condition.
Some bacteria take over cells by interfering with an important process called SUMOylation, which helps cells respond to stress.
On May 26, Egnor will give a free public lecture titled, "Whistling in the Dark: What Can Mouse Vocalizations Tell Us about the Brain?"
Scientists have uncovered thousands of DNA segments that were missing from the reference sequence of the human genome.
A molecule best known for fighting off cellular clutter is now recognized as an important defender against another cellular threat: viruses.
New research provides details of how genetic mismanagement by RNA can lead to a human disease—in this case, breast cancer.
New research suggests that training to do a new task causes groups of brain cells to “learn” how to work together more efficiently.
A new discovery shows how wing spots evolved in a species of polka-dotted fruit fly, and underscores the concept that evolution likes to tinker with existing genetic machinery.
Kaelin is one of five scientists honored with the 2010 Canada Gairdner International Award in recognition of their contributions to medical science.
New research reveals how genetic and environmental factors influence an organ that has not traditionally taken much of the blame for diabetes and cardiovascular disease.
Researchers have identified key cells involved in zebrafish heart regeneration and begun to decipher the instructions the cells use to carry out their work.
New studies of how the heart develops in mouse embryos have brought researchers closer to understanding how to induce the body’s own cells to rebuild damaged arteries.
Scientists have found several new ways to kill M. tuberculosis, which could lead to the development of alternative drugs.
An ambitious survey has identified differences in the binding of master regulators called transcription factors that affect how genes are expressed in different people.
In a discovery that may one day aid law enforcement in identifying suspects, researchers have found that skin bacteria left behind on keyboards and computer mice can identify the objects’ users.
A new software package promises to greatly speed up scientists’ ability to assemble and manipulate extremely detailed microscope images.
Experiments with an artificial cell surface demonstrate that a tumor’s aggressiveness is strongly correlated to its mechanical pulling power.
New findings about an often fatal neurodegenerative disease suggest that helping a beneficial protein linger a little longer could promote neuron survival.
Researchers have discovered how one New World hemorrhagic fever virus latches onto and infects human cells, offering a much-needed lead toward new treatments.
Las fiebres hemorrágicas del Nuevo Mundo son enfermedades infecciosas emergentes que se encuentran en Sudamérica y que pueden causar síntomas terribles, similares a los del Ébola. Investigadores del HHMI han descubierto exactamente cómo un virus de fiebre hemorrágica del Nuevo Mundo se adhiere e infecta a las células humanas, lo que ofrece una pista muy necesaria para lograr nuevos tratamientos.
Jean-Philippe Vielle-Calzada, becario internacional de investigación del Instituto Médico Howard Hughes (HHMI), se preguntó si podría aprender lo suficiente sobre la genética de la reproducción asexual para aplicarla a las plantas que se producen sexualmente.
An HHMI scientist has moved a step closer to turning sexually-reproducing plants into asexual reproducers, a finding that could have profound implications for agriculture.
Endothelial cells keep blood stem cells dividing healthily in a lab dish much longer and more effectively than previous methods of growing the cells.
A new study suggests that gut microbes might one day be grouped along with inadequate exercise and overeating as a cause of obesity and metabolic syndrome.
The mitochondrial genome, long thought to be nearly identical in every cell in the human body, actually varies to a surprising degree.
At the AAAS Annual Meeting, David Anderson discussed how studies of model organisms such as mice and fruit flies can improve scientists' understanding of the neural basis of emotion.
At the AAAS Annual Meeting on Feb. 20, Owen Witte discussed a new tool to understand how cancers grow—and with it a new opportunity to identify novel cancer drugs.
At the AAAS Annual Meeting on Feb. 20, George Daley described the current climate facing stem cell researchers in the United States.
Researchers have created a group of stem cells from patients who have a disorder that causes accelerated aging and bone marrow failure. Using a genetic reprogramming technique to “turn back the molecular clock” in these cells appears to reset the cells and reverses rapid aging.
A new vaccine tested in 100 West African children triggers the immune system to produce antibodies against the malaria parasite at levels normally seen only in adults who have strong resistance to the disease.
Una nueva vacuna que se probó en 100 niños de África Occidental hizo que el sistema inmune produjera anticuerpos contra el parásito de la malaria en niveles que normalmente sólo se observan en adultos que tienen una fuerte resistencia a la enfermedad.
With a collection of tools for rapidly processing changing visual cues, the eyes and brain work together to create meaningful images from raw signals.
Researchers have found the key factors that cause proteins to turn into sticky, fibrous clumps that can grind cellular activity to a halt.
Two groups of HHMI scientists working independently have identified a critical enzyme that allows a malaria-causing parasite to take over and thrive in human red blood cells.
Dos grupos de científicos del HHMI que trabajaban de forma independiente han identificado una enzima crítica que permite que el parásito que causa la malaria controle los glóbulos rojos sanguíneos humanos y prospere en el interior de los mismos.
Researchers have discovered that when DNA-copying machines run head-on into oncoming traffic, they kick the obstacles out of their way.
With the discovery of a sodium taste receptor, researchers have now identified the molecular receptors, cells, and coding logic for all five basic tastes.
HHMI researchers have developed a new method for growing human liver cells outside the body, which may boost efforts to develop a vaccine or treatment for hepatitis C infection.
Researchers have devised a new method that increases the number of blood vessel-forming cells they can make from human embryonic stem cells.