HHMI researchers have developed a potential TB vaccine that completely eliminates tuberculosis bacteria from infected tissues in some mice.
Distinct areas of the brain process sweet, bitter, salty, and umami tastes.
Designer ion channels that can turn neurons on or off will help researchers understand the connection between behavior and neural circuitry.
The first definitive proof of a weak spot in the parasite's apicoplasts—organelles with ancient plant origins—offers hope for drugs and vaccines against malaria.
New research has classified vertebrate evolution in relation to periods of evolution marked by changes in specific kinds of genes.
Protective chemicals known as interferons may identify themselves by how tightly they grip their receptor at various attachment points.
An HHMI-funded researcher has used online gene expression profiles to match old drugs with diseases in need of treatments.
Next-generation sequencing and stem cell technology have helped scientists identify a mutation that causes retinitis pigmentosa.
Understanding of antibody may help scientists design a longer-lasting vaccine against the influenza virus.
A test that detects a cancer-causing fusion gene in men’s urine could help reduce the number of prostate biopsies performed each year.
Two studies reveal genetic mutations often present in the most common form of head and neck cancer, offering a picture of how the cancer develops and how therapeutics could treat it.
A genetic comparison of E. coli strains, including the one responsible for the recent outbreak of infections in Europe, underscores how rapidly evolving bacterial genomes can lead to the emergence of new pathogens.
Altering the balance of excitatory and inhibitory inputs in the brains of mice disrupts the animals' social interactions.
The neurological problems caused by Fragile X syndrome may be due to excess synthesis of certain proteins.
An immune defense protein uses prion-like qualities to fend off viruses.
Small bits of RNA can cause a connective tissue cell from human skin to transform into a nerve cell.
A new understanding of a gene that is commonly mutated in people with myeloid leukemia could help lead to new treatments.
Scientists have used a gene therapy tool that acts like intelligent molecular scissors to correct the key gene defect in mice with hemophilia B.
Fifteen scientists working in the plant sciences gain flexible support from HHMI and the Gordon and Betty Moore Foundation to move their research in creative new directions.
The Howard Hughes Medical Institute (HHMI) and the Gordon and Betty Moore Foundation (GBMF) have selected 15 of the nation’s most innovative plant scientists to join a new initiative that boosts much needed funding for fundamental plant science research.
Simon Chan is a 2001 Plant Science Program HHMI-GBMF Investigator.
New research pinpoints differences between cancer stem cells in squamous cell cancer and normal stem cells in the skin, which could be exploited to create powerful new anti-cancer therapeutics.
A new study helps explain how fruit flies commit details of their surroundings to memory.
Medzhitov shares Shaw Prize for discoveries related to innate immunity.
Joanne Chory and Thomas Steitz have been elected foreign members of the Fellowship of the Royal Society.
A detailed comparison of DNA and RNA in human cells has uncovered a surprising number of cases where the corresponding sequences are not, as has long been assumed, identical.
HHMI scientists suggest that as many as 20 percent of sporadic autism cases can be explained by spontaneous gene mutations.
Científicos del HHMI sugieren que tanto como un 20 por ciento de los casos de autismo esporádico pueden explicarse por mutaciones genéticas espontáneas.
A class of proteins known for its involvement in muscle development, brain connectivity, and cancer has now been found in the liver, where it spurs sugar production when we need it most.
Adult planarians, masters of regeneration, harbor pluripotent stem cells that appear to have the same all-purpose qualities as embryonic stem cells.
The same signaling pathway can both cause and suppress disease in blood cells.
Six HHMI investigators are among the 72 new members and 18 foreign associates elected today.
With a new animal model of angle-closure glaucoma, researchers have pinpointed a gene that may be to blame.
Human cytomegalovirus hijacks an antiviral protein and uses it to enhance infection by slowing down the host cell’s energy production.
Janelia Farm group leader Mats Gustafsson was a leader in the field of structured illumination light microscopy.
Eight Howard Hughes Medical Institute investigators are among those newly elected to the academy.
New data about what drives aortic aneurysm progression in Marfan syndrome will help guide treatment decisions and inform efforts to develop new therapies.
At any given moment, a few neurons are ready to take charge of the next piece of information to be stored in the brain's hippocampus.
The biological basis of schizophrenia is not fully understood, but new research by HHMI international research scholar Michael Salter offers insights into the disruptions in brain chemistry that underlie the debilitating mental illness.
Using chemical genetics to single out a single kinase among the hundreds inside a cell, scientists have gleaned new information about how one such protein might contribute to cancer-promoting signaling.
New maps detailing where certain markers of genetic regulation are found in a variety of cell types will help researchers interpret large-scale analyses.
A zebrafish model of human melanoma has helped scientists identify new targets for potential therapies.
New research offers a genetic explanation for why some patients' lung tumors disappear almost completely when treated with the drug erlotinib, while other patients' responses are far less dramatic.
Searching for a new food source is a big decision for a worm, based on hunger, dining companions, oxygen availability, and, according to a new study, genetics.
The 2011 prize honors Elaine Fuchs, James Thomson, and Shinya Yamanaka for pioneering work in isolating human stem cells.
Flickering black and white movies show components of the spliceosome coming and going from bits of RNA as they await processing.
The clear and watery substance that bathes the brain and spinal cord is enough to support the growth of neural stem cells in the lab.
Specific traits that distinguish humans from their closest living relatives can be attributed to the loss of chunks of DNA that control when and where genes are turned on.
With the flick of a genetic light switch, researchers have reduced symptoms of anxiety in laboratory mice.
A new genetic method for labeling cells transforms the tangles of neurons within the brain of a fruit fly into fantastic rainbows of color.