Researchers report the first hard evidence that most cases of colon cancer arise when mutations in a genetic "master brake" help to switch on a well-known cancer-promoting gene.
Researchers used to identify important developmental genes one at a time. Now, a technique developed in Drosophila is taking wing, and hundreds of novel genes have been found.
Researchers find that a drug used to treat adult-onset diabetes may promote the formation of colorectal tumors.
The human immune system can recognize and destroy thousands of invaders. Did this diversity come about accidentally when a mobile piece of DNA inserted itself into the mammalian genome more than 450 million years ago?
Researchers discover new details about how cells monitor the signals that stimulate proliferation or shut down cell growth. Such signals can turn a normal cell into one that grows uncontrollably, the first step in the development of cancer.
Salt is poison for people with high blood pressure. Genetic studies are beginning to clarify who is at risk and why.
Scientists Determine Structure of HIV-1 Protein that Grasps Human Cells.
Researchers have identified a faulty conduit into nerve cells that causes them to fire uncontrollably, triggering the brief seizures that characterize some forms of epilepsy.
eCircadian clocks maintain the sleep-wake cycle for a 24-hour day in a variety of organisms. Two HHMI researchers and their colleagues have discovered more of the clock's molecular components.
Hughes investigators have discovered a family of packemaker ion channels that power the heart and the brain
Knockout mice point the way to a new theory of how a ubiquitous protein may promote heart disease.
HHMI researchers have discovered a genetic mutation that damages heart muscle so that it dilates to the point where the heart can no longer pump blood.
Familial hypertrophic cardiomyopathy is the most common underlying cause of sudden cardiac death in young athletes. New research suggests the disorder may be more widespread than previously thought.
Research to improve vaccines for infectious diseases must move forward. At the same time, according to HHMI investigator Barry Bloom, scientists should be perfecting vaccines that tackle pathogens associated with other diseases, such as cancer and heart disease.
Hughes investigators have discovered that a compound produced by the ocean-dwelling sponge Haliclona shuts down the ubiquitous cellular motor proteins that power cell division and a variety of other processes.
For nearly 50 years, scientists have wondered what a potassium channel looks like. Now, an HHMI research team at The Rockefeller University unveils the channel's surprising architecture.
Spontaneous neural activity in the developing brain is necessary to help organize the detailed connections that exist in the visual system.
Recent research may help clarify whether type 2 diabetes is caused by errant genes or faulty biology.
How does a virus inactivate a tumor suppressor protein? Hughes researchers have crystallized one key tumor suppressor in the act of being handcuffed by a fragment of the human papilloma virus.
The discovery of two nerve cell hormones and their receptors may help explain how the brain senses hunger signals and responds by increasing appetite.
Hughes investigators have identified two of the Ebola virus's main targets in the human body. They are now working on a vaccine against Ebola virus that primes the immune system to ward off the virus.
Three teams of Hughes researchers are closer to understanding how axons, the long projections of nerve cells, grow toward and across an organism's midline to wire up both sides of the body.
HHMI researchers have determined the three-dimensional structure of a protein-RNA complex that shepherds the production of infectious copies of HIV. The structure is a promising target for new antiviral drugs. Article published in the January 16, 1998 issue of Science.
Researchers suspect that a combination of genes and environment determine one's susceptibility to allergic conditions. Hughes researchers and colleagues at Washington University have identified a mutant protein that may cause hypersensitivity to common allergens.
HHMI physician postdoctoral fellow Michael Yaffe and his colleagues have demonstrated a new mechanism that governs chaperone activity and affects the vitality of cells.
Benjamin Doranz, an HHMI predoctoral fellow, is helping to devise a gene therapy technique that could destroy the hidden, latent reservoir of HIV-infected cells that escape drug therapy. Article published in the November 21 issue of Science.
HHMI international scholar B. Brett Finlay hopes to learn exactly how E. coli adheres to target cells - and to improve the treatment of diarrheal diseases.
Research by an undergraduate at the University of South Carolina could lead to a better understanding of the genetic relationship among dinosaurs, birds and alligators.
Lisa Goodrich and HHMI investigator Matthew Scott are probing how genes that guide normal development can sometimes go awry and lead to cancer.
Two Hughes investigators, working in parallel, advance our understanding of AIDS by discovering the way HIV, the virus that causes AIDS, penetrates a cell.
Hughes researcher Yuet Wai Kan and his colleagues have designed a prenatal blood test to diagnose fetuses at risk for developing sickle cell anemia and thalassemias.
Hyock Joo Kwon has helped to determine the structure of the active site of bacteriophage lambda integrase, a well-studied protein that had proven difficult to visualize.
Stephen Blacklow, a former HHMI postdoctoral fellow, has made a discovery that may explain why some people have high cholesterol levels
Jeffrey M. Friedman and colleagues report that the weight-reducing effects of the hormone leptin result from interaction with a receptor in the brain's hypothalamus and other tissues.
Graeme Bell and other researchers have found a gene that may make people susceptible to type II diabetes.
A team of HHMI scientists has peered deep inside HIV-1 for a closer view of the fragile shell that envelops the virus' genetic material.
Dan Littman and fellow researchers have found a receptor for HIV that appears to play a key role in the transmission of the virus between individuals.
Michael Naski has helped to identify a genetic mutation that can cause bones to stop growing, leading to a form of dwarfism.
HHMI researchers have learned that basal cell carcinoma is caused by a defect in a gene that restrains cell growth.
HHMI scientists at the University of Texas Southwestern Medical Center are blocking the enzyme telomerase in a new strategy to prevent cancer cells from dividing.
Don Ganem's decision to search for a viral cause for Kaposi's sarcoma was considered risky by many molecular biologists.
Sharon Long's studies of signal transduction pathways in plants could yield insights into cancer and other diseases in humans.
Hughes researchers have developed a technique that may speed the identification of more tumor suppressor genes.
International research scholar Alec Jeffeys believes that radiation leaked from Chernobyl more than a decade ago may only now be manifesting its diastrous legacy.
Students at Texas Tech University are co-authors on a Nature paper showing a high rate of genetic change in rodents living near the Chernobyl reactor.
HHMI investigator Michael J. Welsh's research team has found that the airways of CF patients lack a natural substance that kills bacteria.
Hughes investigator Ronald D. Vale's research provides fresh insight into the structure and operation of the motor proteins that convert chemical energy in the cell into physical movement.