A new understanding of a gene that is commonly mutated in people with myeloid leukemia could help lead to new treatments.
Scientists have used a gene therapy tool that acts like intelligent molecular scissors to correct the key gene defect in mice with hemophilia B.
Fifteen scientists working in the plant sciences gain flexible support from HHMI and the Gordon and Betty Moore Foundation to move their research in creative new directions.
The Howard Hughes Medical Institute (HHMI) and the Gordon and Betty Moore Foundation (GBMF) have selected 15 of the nation’s most innovative plant scientists to join a new initiative that boosts much needed funding for fundamental plant science research.
Simon Chan is a 2001 Plant Science Program HHMI-GBMF Investigator.
New research pinpoints differences between cancer stem cells in squamous cell cancer and normal stem cells in the skin, which could be exploited to create powerful new anti-cancer therapeutics.
A new study helps explain how fruit flies commit details of their surroundings to memory.
Medzhitov shares Shaw Prize for discoveries related to innate immunity.
Joanne Chory and Thomas Steitz have been elected foreign members of the Fellowship of the Royal Society.
A detailed comparison of DNA and RNA in human cells has uncovered a surprising number of cases where the corresponding sequences are not, as has long been assumed, identical.
HHMI scientists suggest that as many as 20 percent of sporadic autism cases can be explained by spontaneous gene mutations.
Científicos del HHMI sugieren que tanto como un 20 por ciento de los casos de autismo esporádico pueden explicarse por mutaciones genéticas espontáneas.
A class of proteins known for its involvement in muscle development, brain connectivity, and cancer has now been found in the liver, where it spurs sugar production when we need it most.
Adult planarians, masters of regeneration, harbor pluripotent stem cells that appear to have the same all-purpose qualities as embryonic stem cells.
The same signaling pathway can both cause and suppress disease in blood cells.
Six HHMI investigators are among the 72 new members and 18 foreign associates elected today.
With a new animal model of angle-closure glaucoma, researchers have pinpointed a gene that may be to blame.
Human cytomegalovirus hijacks an antiviral protein and uses it to enhance infection by slowing down the host cell’s energy production.
Janelia Farm group leader Mats Gustafsson was a leader in the field of structured illumination light microscopy.
Eight Howard Hughes Medical Institute investigators are among those newly elected to the academy.
New data about what drives aortic aneurysm progression in Marfan syndrome will help guide treatment decisions and inform efforts to develop new therapies.
At any given moment, a few neurons are ready to take charge of the next piece of information to be stored in the brain's hippocampus.
The biological basis of schizophrenia is not fully understood, but new research by HHMI international research scholar Michael Salter offers insights into the disruptions in brain chemistry that underlie the debilitating mental illness.
Using chemical genetics to single out a single kinase among the hundreds inside a cell, scientists have gleaned new information about how one such protein might contribute to cancer-promoting signaling.
New maps detailing where certain markers of genetic regulation are found in a variety of cell types will help researchers interpret large-scale analyses.
A zebrafish model of human melanoma has helped scientists identify new targets for potential therapies.
New research offers a genetic explanation for why some patients' lung tumors disappear almost completely when treated with the drug erlotinib, while other patients' responses are far less dramatic.
Searching for a new food source is a big decision for a worm, based on hunger, dining companions, oxygen availability, and, according to a new study, genetics.
The 2011 prize honors Elaine Fuchs, James Thomson, and Shinya Yamanaka for pioneering work in isolating human stem cells.
Flickering black and white movies show components of the spliceosome coming and going from bits of RNA as they await processing.
The clear and watery substance that bathes the brain and spinal cord is enough to support the growth of neural stem cells in the lab.
Specific traits that distinguish humans from their closest living relatives can be attributed to the loss of chunks of DNA that control when and where genes are turned on.
With the flick of a genetic light switch, researchers have reduced symptoms of anxiety in laboratory mice.
A new genetic method for labeling cells transforms the tangles of neurons within the brain of a fruit fly into fantastic rainbows of color.
Janelia researchers create a new microscope that uses a thin sheet of light to reveal the dynamic inner life of cells.
Triple-negative tumors lack three traits that can be targeted by available breast cancer treatments. But new findings suggest treatment possibilities for these aggressive cancers may be at hand.
A newly identified genetic marker appears to predict a diagnosis of post-traumatic stress disorder in women, but not in men.
A rapid new method of blocking gene function is letting researchers dissect how stem cell progenitors in the skin split their energy between creating copies of themselves and crafting specialized new cells.
A corrective strategy used by astronomers to sharpen images of celestial bodies can now help scientists see with more depth and clarity into the living brain of a mouse.
Scientists have used next-generation DNA sequencing tools to identify a mutation in a gene that underlies one of the most common forms of severe hypertension.
Neurons that control aggression and mating are closely intertwined deep within the brain.
Researchers gain a new view of how genes are converted to protein by freezing the action during the earliest stage of the process.
Researchers at Stanford University have discovered that they may be able to tweak cancer cells so that they summon their own demise.
In mice with light-sensitive neurons in their brain, illuminating one type of neuron drives the animals to their food bowls, whereas targeting a different type makes them abstain.
After a rapid genetic analysis of bacteria collected from Haitian patients, scientists conclude that the strain of cholera currently sweeping through post-earthquake Haiti originated in South Asia.
HHMI has launched an international competition to select up to 35 early career scientists working at academic institutions in 18 countries on five continents.
A study in fruit flies shows that turning back the clock on aging muscles delays aging in the whole animal.
Safe and effective vaccines could complement efforts to treat those already infected with cholera and provide clean water and sanitation to control its spread.
A new study has pinned some of the symptoms of Rett syndrome to a set of neurons that usually work to rein in nerve cell firing in the brain.
New research suggests rising temperatures in the highlands of East Africa are at least partly to blame for the increase in malaria transmission in recent decades.