Researchers have greatly shortened the time it takes to create a mouse model of human liver cancer, and used the technology to identify two genes that drive the disease.
HHMI researchers discover that brittle prion particles break into new "seeds," which spread infection quickly.
Defects in a critical cellular pathway can lead to symptoms of Parkinson's disease.
Neurons in the brains of mice sprout robust new connections when the animals adjust to new experiences.
Researchers obtain the first definitive look at how a protein often implicated in cancer development turns itself on to promote cell growth.
An experimental drug reverses the signs and symptoms of patients whose chronic myeloid leukemia has failed to respond to Gleevec.
Certain variants of a simple sugar ameliorate Alzheimer's disease in mice.
A handful of Pittsburgh high school and college students who isolated and characterized 30 new viruses that infect bacteria have co-authored a research article in a peer-reviewed scientific journal.
With help from some drowsy fruit flies, HHMI researchers identify a region of the brain that controls sleep.
HHMI researchers at Stanford have found that they can increase bone mass in mice by tweaking the shape of a regulatory protein.
Researchers discover a clue to how bacteria can spread through an insect population.
A new resource will speed understanding of inherited disorders that kill cells in the brain.
HHMI researchers show that reducing production of sterols can prevent the rapid growth of medulloblastoma cells in culture.
New technique allows scientists to measure the abundance of thousands of proteins with unprecedented resolution.
A new panel of compounds may be a powerful tool to evaluate cellular enzymes as potential targets for drug design.
HHMI researchers pioneer a new approach to determining the structure of protein complexes.
Scientists have mapped a critical hormone signaling pathway that regulates the stature of plants.
The repeated copying of a small segment of DNA in the genome of a primeval fish may have been crucial to the transition of ancient animals from sea to land.
Científicos mapean una vía de señalización hormonal que regula la estatura de las plantas.
Researchers have a new understanding of how sperm and eggs begin life with exactly one copy of each chromosome.
Patients with multiple sclerosis carry a population of immune cells that over-react to Epstein-Barr virus.
Researchers have identified a protein that reins in the rogue activity of the molecules that make the amyloid-beta protein, which may prevent normal brain function in people with Alzheimer's disease.
Five current HHMI investigators, one trustee of the Institute, one member of the Institute's scientific review board, and one HHMI international research scholar were among those honored.
Seven HHMI investigators, along with an HHMI professor, an international research scholar, and a member of the scientific review board are elected to the academy.
Researchers have created a mouse model that closely mimics the most common childhood brain tumor.
HHMI research shows that evolution is an incessant tinkerer when it comes to complex traits.
Researchers have discovered the first African hantavirus, a type of rodent-borne virus that can cause life-threatening infections in humans.
A change in a single gene may be in large part responsible for the evolution of flight in bats.
Researchers find new clues to why some kinds of leukemia are more aggressive and deadly than others.
A common blood pressure medication may help prevent potentially deadly complications of Marfan syndrome.
Cells use specialized segments of RNA to ensure that there is an adequate supply of magnesium.
Una medicación comúnmente prescrita para la presión sanguínea puede proporcionar el primer atisbo de esperanza para la prevención de las complicaciones potencialmente mortales del síndrome de Marfan, una enfermedad genética que debilita la intrincada estructura de vasos sanguíneos.
Researchers have identified a gene mutation that weakens small blood vessels, increasing the danger of stroke.
Joan A. Steitz and Ronald M. Evans have received the Gairdner International Award.
New research indicates there is a useful difference between cells that keep the blood system healthy and the stem cells that make leukemia lethal.
Scientists have traced female fruitflies' complex behavioral change after mating to a single protein in the semen of males.
HHMI researchers have discovered a new retrovirus in humans that is closely related to a cancer-causing virus found in mice.
Enzymes that can harm the brain immediately after a stroke may actually be beneficial days later.
Sustained over the long term, a decrease in low density lipoprotein (LDL) cholesterol of as little as 15 percent can dramatically reduce the risk of coronary heart disease.
Researchers have mathematically confirmed that humpback whales have their own syntax that combines sounds into phrases to form songs that last for hours.
HHMI researchers have demonstrated that they can nearly eliminate production of infectious prion proteins in livestock by using an innovative approach based on RNA interference (RNAi).
A new color-changing tag based on the light produced by a variety of sea coral could help scientists follow individual proteins inside living cells.
An HHMI research team has identified the cellular receptor for botulinum neurotoxin A.
Equipo de investigadores del HHMI identifica el receptor celular de la toxina botulínica A.
A rare opportunity to study patients with an intractable form of epilepsy leads to the discovery of specific neurons in the human brain that respond to novel or familiar objects.
Researchers studying strains of a lethal canine virus and a related human virus have determined why the canine virus was able to spread so quickly from cats to dogs and then from sick dogs to healthy dogs.