Mario Capecchi received a Kyoto Prize from the Inamori Foundation in 1996. The lecture he delivered when he accepted the prize in Japan in November 1996 tells the story of his remarkable life. The text of the lecture has been edited for length.
New studies establish how the stress hormone norepinephrine boosts learning by strengthening connections between neurons.
Scientists have traced the 170 million-year evolution of a piece of "junk" DNA to its modern incarnation as an important regulator of energy balance.
Científicos rastrean la evolución que tuvo, durante 170 millones de años, un pedazo de ADN “basura” hasta encontrar su encarnación moderna como regulador importante del balance energético.
HHMI researchers have figured out how a bacterial circadian clock ticks away using only three interacting proteins.
Researchers have demonstrated how tens of thousands of closely related proteins establish the specificity that allows them to serve as identification tags for individual neurons.
Researchers have determined the identity of a significant feature that makes a neuron a recycler par excellence.
Scientists have succeeded in reprogramming adult stem cells from the testes of male mice into functional blood vessels and contractile cardiac tissue.
A chemical produced when the body breaks down cholesterol inhibits the activity of estrogens circulating in the blood.
Individual variability in innate immunity may leave some people dangerously exposed to common pathogens such as herpes simplex virus.
A genetic mutation found in some people with autism and Asperger syndrome causes social impairment and cognitive enhancement in mice.
Researchers have provided insight into how mutations in a single gene can cause mental retardation and kidney dysfunction in boys with Lowe syndrome.
Studies reveal why the same prion protein can be either weakly or strongly infectious.
HHMI researchers have identified an "emergency" mechanism that yeast cells use to switch on protein synthesis in times of stress.
A red sea anemone purchased in a Moscow pet shop provides a blueprint for a more vivid red fluorescent protein.
Photosensing proteins drive the spread of a bacterial infection that costs cattle farms in Brazil and Argentina up to $100 million a year.
A systematic strategy may uncover the different developmental steps and cellular machinery used to build axons and dendrites.
Proteínas fotosensibles conducen la diseminación de la brucelosis vacuna, que es una infección bacteriana que le cuesta a las haciendas en Brasil y Argentina hasta $100 millones de dólares por año.
Researchers are learning how the neurons of people with Lafora disease accumulate toxic amounts of carbohydrates.
Investigadores aprenden la forma en la que las neuronas de las personas con la enfermedad de Lafora acumulan cantidades tóxicas de carbohidratos.
In mending the DNA broken during antibody production, immune cells can employ a type of DNA repair that is fundamentally different than the classical method.
HHMI scientists have created a completely new enzyme entirely in vitro.
A colorful new palette of fluorescent tags promises to give researchers a better view of life at the molecular level.
When pathogenic microbes or chemicals inflame the intestine, the balance of microbial power shifts.
A molecule that constantly reinvents itself is one of the many ingenious mechanisms that the malaria parasite has evolved to protect itself against the human immune system.
Mother's milk can turn toxic if the molecular pathways that govern its production are disrupted.
La leche materna puede volverse tóxica si se descomponen las vías moleculares que gobiernan su producción.
Researchers have identified a new mechanism by which tricyclic antidepressants (TCAs) inhibit neurotransmitter transporters.
Scientists uncover significant differences in the mature, functioning neurons generated from two NIH-approved stem cell lines.
Científicos descubren diferencias significativas en neuronas maduras y funcionales generadas a partir de dos líneas de células troncales aprobadas por el NIH.
By short-circuiting the sensory organ that detects the chemical cues mice use to attract mates, researchers have prompted female mice to behave like male mice in the throes of courtship.
Researchers have produced a genetically altered strain of tuberculosis that elicits a stronger immune response than the current vaccine.
A new delivery vehicle for transplanted islet cells may help clinicians track the cells once they are inside the body.
Researchers have discovered a protein that fetal, but not adult, blood-forming stem cells need to replenish themselves.
The traditional prescriptions for a healthy life—sensible diet, exercise and weight control—extend life by reducing signaling through a specific pathway in the brain.
Las recomendaciones tradicionales para tener una vida sana—dieta prudente, ejercicio y control de peso—extienden la vida al reducir la señalización que se lleva a cabo mediante una vía específica del cerebro.
A protein whose function is lost in a broad array of cancers normally suppresses prostate cancer metastasis, researchers have shown in studies with mice.
HHMI researchers have found that insulin resistance in skeletal muscle leads to alterations in energy storage that set the stage for the metabolic syndrome.
A new device may make the most reclusive members of microscopic communities much more accessible for laboratory study.
It can take hours, or even days, for a virus to infect a cell. But poliovirus is more efficient than the average virus.
A new link between inflammation and cancer has revealed how the body's natural response to tissue injury can actually spur tumor growth.
A new study shows how loss of a single enzyme that performs two critical functions can create the potential for cancer when immune cells divide and mature.
Laboratory experiments have enabled researchers to bypass half a billion years of evolution, giving one protein the ability to function like a distantly related protein with just a few simple changes.
Genetic analysis of a year's worth baby poop has given researchers a detailed picture of how bacteria come and go in the intestinal tract.
Scientists have found that they can modify naturally occurring viruses to create targeted weapons against biofilms.
Treating hepatitis B patients with the drug entecavir can cause those who are also infected with HIV to become resistant to two of the most important drugs in the anti-HIV arsenal.
Zebrafish produce natural chemicals that enhance production of blood-forming stem cells.
El tratar a pacientes con hepatitis B usando la droga entecavir puede hacer que quienes también están infectados con el VIH se vuelvan resistentes a dos de las drogas más importantes del arsenal contra el VIH.
El descubrimiento de que el pez cebra produce productos químicos naturales que incrementan la producción de células troncales de formación de sangre podría traducirse rápidamente a nuevos tratamientos para aumentar la eficacia de los transplantes humanos de médula ósea o de cordón umbilical.
Identifying the complete set of genes whose activity is altered by disease used to appear impossible. Not anymore.