Susan Lindquist believes that if “personalized medicine” for complex neurodegenerative disorders is to become a reality then scientists must begin developing more rigorous approaches to identifying and validating promising new therapies.
Images in biology textbooks may give the misleading impression that the cell membrane is a passive envelope that does little more than keep the cell’s internal contents in place. Howard Hughes Medical Institute researcher Douglas C. Rees prefers to think of the outer membrane of human cells as a dynamic boundary that sends and receives vital information about the state of affairs inside and outside the cell.
Ants first marched into Danny Reinberg’s world about four years ago as he began thinking about taking his lab in a new direction. Now, he cannot keep ants off his mind because they are the focal point of a newly funded HHMI Collaborative Innovation Award to study whether epigenetics influences the behavior and aging of ants.
In mammals, cells carry out their work driven by two copies of nearly every gene, one inherited from each parent. If something happens to one gene, the other is usually there to compensate. But for a small number of genes, the two copies rule does not apply. For those genes, only one parent’s copy is turned on,and the other is shut off. This regulatory process leaves little room for error because there is no gene to act as a backup if problems arise.
Nearly 70 million people worldwide have glaucoma, an insidious group of diseases that damages the optic nerve and leads to vision loss and blindness. High intraocular pressure, which damages nerve cells in the eye, is one of the biggest known contributing factors in the development of glaucoma.
HHMI broadens its research support with the announcement of a new program to foster collaboration and innovation.
HHMI announces the names of scientists selected to pilot a new program devoted to supporting transformative, collaborative research.
Researchers have traced the sequence of metabolic events that kill E. coli bacteria when they are treated with the antibiotic gentamicin.
New images from HHMI scientists show the stunning dynamics of HIV reverse transcriptase zooming around on the very DNA it is building.
A tiny RNA switch may play a big role in the spread of prostate cancer.
Researchers have discovered three genetic factors that could help doctors identify people who are at the greatest risk for developing a brain aneurysm.
Al escudriñar los genomas de más de 10.000 personas, unos investigadores han descubierto tres factores genéticos que podrían ayudar a que los doctores identifiquen las personas que tienen el mayor riesgo de desarrollar una aneurisma cerebral.
Researchers have developed a method for systematically screening cancer cells to detect genes likely to suppress metastasis.
Researchers have identified the chief motor protein that hauls the building materials needed for learning to their destinations inside neurons.
A new technique factors a protein's flexibility into the drug design equation. It's paying off in a big way.
New technology makes it possible to study tissue samples locked away for decades.
Nueva tecnología hace posible el estudio de muestras de tejidos guardadas por décadas.
New studies show how the brain changes when mice learn to feel safe and secure in situations that would normally make them anxious.
Roger Tsien, Osamu Shimomura, and Martin Chalfie honored for the discovery and development of the green fluorescent protein, a ubiquitous research tool.
Roger Tsien, Osamu Shimomura and Martin Chalfie son galardonados por el descubrimiento y desarrollo de la proteína fluorescente verde, que es una herramienta general de investigación.
HHMI researchers devise prenatal blood test that accurately detects Down syndrome and two other serious chromosomal defects.
Investigadores del HHMI desarrollan un nuevo análisis de sangre prenatal que detecta con precisión el síndrome de Down y otros dos defectos cromosómicos serios.
HHMI researchers have found microRNAs in animal species whose last common ancestors were present on Earth about 1 billion years ago.
HHMI researchers have developed a new model of cystic fibrosis in pigs that more accurately mimics features of the disease.
Investigadores del HHMI han desarrollado un nuevo modelo de fibrosis quística en cerdos que imita de forma más precisa las características de la enfermedad que se observa en infantes humanos.
Researchers have identified a gene from a new family of ion channels that help to regulate smell and taste sensing, smooth muscle contraction, and fluid secretion in glands and airways.
A newly identified "hot line" connects a worm's nervous system to its immune system.
Investigadores han descubierto una “línea directa” de comunicación que le permite al sistema nervioso de un gusano llamar al sistema inmune para coordinar la respuesta a patógenos infecciosos.
Researchers have learned how Listeria crosses the placenta from mother to baby.
Researchers have devised clever techniques to visualize gene silencing in its natural context.
A gene deletion caused mice to exhibit behavioral and brain changes common in people with Alzheimer's disease or dementia.
Researchers may be able to fight malaria by targeting human liver cells instead of parasites
Las drogas contra la malaria existentes atacan al parásito que causa la enfermedad, pero están perdiendo eficacia debido al aumento en la resistencia a drogas. Investigadores del Instituto Médico Howard Hughes informan que podrían ser capaces de combatir la malaria atacando células humanas hepáticas en lugar de a los parásitos.
A immunosuppressant drug may unexpectedly fight the parasite-caused disease.
Scientists have detected a multitude of broken, missing, and overactive genes in the most detailed genetic survey yet of any human tumor.
Mediante el examen genético más detallado de cualquier tumor humano que se haya realizado hasta el momento, científicos encuentran que en tumores pancreáticos y cerebrales una variedad de genes están rotos, hiperactivos o desaparecen.
Researchers have generated insulin-producing beta cells from adult pancreatic cells in living mice.
Investigadores del HHMI han transformado células pancreáticas adultas en células betas productoras de insulina en ratones vivos.
Researchers have begun scouring cancer cells for potential sites of resistance against a new class of drugs.
Researchers have shown that bacterial communication can be intercepted and chemically manipulated to control group behavior, such as virulence or the production of a useful products.
Researchers have converted cells from individuals with ten different diseases, including muscular dystrophy, juvenile diabetes, and Parkinson's disease, into stem cells.
Scientists have identified more than 300 human genes that influence West Nile virus infection. More than 20 of these cooperate with the virus, whereas the others help cells resist it.
Researchers have used new technology to pinpoint a critical gene mutation in worms in only a few weeks. It would have taken years for scientists using older technology to sift through the worm's DNA until they found the proverbial needle in the haystack.
Researchers have identified a genetic defect that makes some children susceptible to attack by a certain type of bacteria, a finding that will speed up diagnosis and treatment.
Investigadores del HHMI han identificado dos drogas que imitan muchos de los efectos fisiológicos del ejercicio.
HHMI researchers have identified two drugs that mimic many of the physiological effects of exercise.
Researchers have revealed an important step in the process that guides neurons as they establish precise connections between the spinal cord and muscles.
An international team of researchers has identified a gene mutated in Duane syndrome, a common disorder that restricts the movement of the eyes.
Thanks to a set of fruit flies that seem to get by with far less dozing than most, researchers has found a gene absolutely necessary for snoozing.