Janelia researchers show that Hox proteins trigger gene activity through weak interactions at previously unrecognized DNA binding sites in the genome.
Scientists have determined new structures of an essential cellular recycling machine with near atomic-level detail. The structures, which show a protein called NSF alone and interacting with its target, a protein complex called SNARE that is formed when membranes fuse together.
HHMI scientists and their colleagues discover a new mechanism of protein synthesis.
Researchers at HHMI's Janelia Research Campus have used motion-capture technology to reveal new insight into the sophisticated information processing and acrobatic skills of dragonflies on the hunt.
HHMI investigator Jennifer Doudna is among six scientists honored for transformative advances toward understanding living systems and extending human life.
Lattice light sheet microscopy, a new imaging platform developed at Janelia, lets biologists see 3-D images of subcellular activity in real time.
Eric Betzig, director de grupo en Janelia, gana el Premio Nobel por el desarrollo de la microscopía de fluorescencia de super-resolución.
Janelia group leader Eric Betzig wins Nobel Prize for the development of super-resolved fluorescence microscopy.
Retracing the ancient battles between jumping genes and the defenses human cells deploy to keep them in check.
Janelia scientists are learning how the brain switches between random and strategic modes.
HHMI scientists have shown that previously unrecognized groups contributed to the genetic mix now present in most modern-day Europeans.
HHMI Investigator Sangeeta Bhatia is recognized for designing and commercializing miniaturized technologies with applications to improve human health.
HHMI Investigator Peter Walter of UCSF shares the 2014 Albert Lasker Basic Medical Research Award with Kazutoshi Mori of Kyoto University.
New research by HHMI scientists shows that the emotional memory of an experience is malleable.
Janelia scientists are learning how the brain makes sense of new places.
HHMI scientists have devised a technique to identify hard-to-find gene mutations that crop up in a fraction of the body's cells.
By studying dirty flies, Janelia scientists hope to learn how animals carry out sequences of movements that make up more complex behaviors.
Big data can mean big headaches for scientists. A new library of software tools from Janelia speeds analysis of data sets so large and complex they would take days or weeks to analyze on a single workstation—if a single workstation could do it at all.
Janelia researchers develop a new computational method that can essentially automate much of the time-consuming process of reconstructing an animal's developmental building plan cell by cell.
HHMI and GBMF announce the establishment of an Advanced Imaging Center at Janelia that will make leading-edge imaging technologies more widely available to the scientific community before the instruments are available commercially.
Every millisecond counts when a fruit fly is being hunted by a damselfly. Janelia scientists find that fruit flies can deploy two escape behaviors, depending on circumstances.
HHMI researchers find that a single-letter change in the genetic code is enough to generate blond hair in humans.
HHMI scientists develop new tool to silence neurons with an unprecedented level of control.
Janelia researchers speed up image-processing time and get sharper microscopy images by employing techniques used by astonomers and ophthalmologists.
John P. Donoghue, Director of the Institute for Brain Science at Brown University, will speak on April 30 at 7PM at Janelia.
HHMI researchers have tested the olfactory capacity of human volunteers and found that humans are capable of discriminating at least one trillion different odors.
HHMI researchers show that rising temperatures can cause spread of malaria to areas where the disease had not been endemic historically.
Investigadores del HHMI demuestran que el aumento de temperaturas puede causar la dispersión de la malaria en zonas donde la enfermedad no ha sido endémica históricamente.
Howard Hughes Medical Institute (HHMI) scientists have created a portrait of a DNA-snipping protein called Cas9, a powerful research tool used in many labs for genome editing.
New research from HHMI scientists reveals how a foreign-DNA-destroying system, known as CRISPR, efficiently locates its DNA targets within a bacterial genome.
By studying which genes modern humans still retain from our Neanderthal ancestors, researchers are able to tell a clearer story about the biological impact of human-Neanderthal interbreeding.
HHMI seeks to appoint up to 25 new biomedical researchers through a national open competition.
HHMI researchers identify a potential Achilles heel in the oncogene K-Ras.
A new technique developed by Janelia researchers allows scientists to use electron beams to determine protein structure from tiny crystals.
New evidence suggests that aneuploidy patterns of chromosome deletion or amplification that are recurrent among tumors actually represent a driving force during tumor evolution and are very frequent in cancer.
HHMI researchers have discovered that the pool of inactive HIV viruses that lingers silently in a patient’s body is larger than expected. The viruses continue to be a threat because they retain the ability to become active even after treatment with the best HIV drugs.
HHMI researchers have developed a mouse model of scleroderma. Their studies have uncovered some of the molecular pathways that go awry to cause the disease.
Neurons deep in the fly’s brain tune in to some of the same basic visual features that neurons in bigger animals such as humans pick out in their surroundings. The new research is an important milestone toward understanding how the fly brain extracts relevant information about a visual scene to guide behavior.
HHMI researchers have designed an inhibitor that can reduce the expression of the mutated gene that causes hypertrophic cardiomyopathy, a potentially fatal heart condition.
La Real Academia de las Ciencias Sueca anunció que los investigadores del HHMI, Randy W. Schekman y Thomas C. Südhof, y James E. Rothman de la Universidad de Yale son los ganadores del Premio Nobel de Fisiología o Medicina 2013 por sus descubrimientos sobre la maquinaria que regula el tráfico de vesículas, un importante sistema de transporte de nuestras células.
The Nobel Assembly at the Karolinska Institute announced that HHMI investigators Randy W. Schekman and Thomas C. Südhof, and Yale's James E. Rothman are the recipients of the 2013 Nobel Prize in Physiology or Medicine for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells.
Janelia scientists launch collaboration to develop a new generation of devices to detect neural activity.
Some breast cancer cells have a leg up on survival—the genes they express make them more likely to spread and prosper in bone tissue.
Scientists have discovered that an active ingredient in an over-the-counter skin cream slows or stops the effects of Parkinson’s disease on brain cells.
New thinking and technological innovation help Janelia researchers piece together a complex map of the neuronal connections that flies use to detect motion.
By activating a subset of brain cells in mice, researchers changed the way the animals remembered a particular setting.
New research reveals the cellular network that activates temperature-sensitive changes in an infectious fungus.
A new protein engineered by scientists at the Janelia Farm Research Campus fluoresces brightly each time it senses calcium, giving the scientists a way to visualize neuronal activity. The new protein is the most sensitive calcium sensor ever developed and the first to allow the detection of every neural impulse.
New research reveals details of changing DNA methylation patterns as the brain matures.