Waging an immunological war against a pathogen is not the body’s only way to survive an infection. Sometimes learning to live with an invader can be just as important.
Scientists have discovered a hormone that causes the body’s insulin-producing factories, beta cells, to churn out more of themselves.
A new technique transforms biological tissue into an optically transparent sample that retains its original structure and molecular information.
Stephen Elledge recognized for research on DNA repair.
New research reveals how a localized source of a signaling molecule directs a dividing stem cell to produce two different cells—one identical to its parent, the other a more specialized cell type—and aligns those cells.
Researchers have found that temperatures on the surface of the tropical South Atlantic Ocean in July can predict the severity of malaria outbreaks in northwestern India that begin to peak four months later.
Scientists have a new view of the cellular machinery that assembles directly on DNA and readies it for transcription into RNA, the first step in protein production.
Three HHMI scientists are among 11 honored for excellence in research aimed at curing intractable diseases and extending human life.
Scientists have discovered that periodic ring-shaped actin arrangements encircle the long axonal fibers of nerve cells, in contrast to the linear meshworks that typically give cells their shapes.
HHMI scientists discover how a single molecule in a living cell can respond differently to different strengths of an external signal.
A new analysis suggests that the regulatory protein MeCP2 works with the modified nucleotide 5hmC to facilitate gene activation in the brain.
Scientists have discovered the molecular pathway responsible for detecting loose bits of DNA outside a cell’s nucleus and setting off an immune reaction.
Rather than scrutinizing hours of video, scientists can quickly teach the software how to recognize key behaviors.
AAAS recognizes Ulrike Heberlein and Nelson Spruston for meritorious efforts to advance science.
A new DNA sequencing technique has enabled researchers to map for the first time the influential chemical modifications known as methylation marks throughout the genome of a pathogenic bacterium.
eLife makes first collection of research articles available online.
Robert Lefkowitz de HHMI comparte el premio con Brian Kobilka por estudios sobre los receptores acoplados a proteínas G.
Only a few animals, such as songbirds, whales, and dolphins, are known to be vocal learners, modifying the sequence or pitch of their sounds based on what they hear from other members of their species. New evidence suggests mice can be added to that list.
HHMI's Robert Lefkowitz shares prize with Brian Kobilka for research on G-protein coupled receptors.
HHMI and the University of KwaZulu-Natal open new research institute in Durban, South Africa.
In experiments with rats, researchers found that the rejection of an old belief correlates with abrupt changes in activity in a region of the brain involved in cognitive functions such as reward anticipation and decision-making.
HHMI selects 13 of the world’s leading basic science researchers to receive Senior International Research Scholar (SIRS) awards. The awards support outstanding biomedical scientists working outside the United States who have made significant contributions to fundamental research in the biological sciences.
HHMI investigator Ronald D. Vale of UCSF will share the 2012 Albert Lasker Basic Medical Research Award.
Thousands of genes in organs throughout the body show predictable daily fluctuations. New research reveals complexity in how those genes' cycles of activity are controlled.
A discovery of how ethylene triggers changes in gene activity could lead to new ways to stop or slow ripening.
The vaccinia virus increases the size of its genome when it confronts the immune system, thereby increasing the odds of a random mutation that will improve its survival.
By investigating the cause of a fatal snake disease, scientists have found a virus that links two known virus families that can cause fatal hemorrhagic fevers in humans.
Mutations in four different DNA damage repair genes have been linked to chronic kidney disease.
Scientists have catalogued and compared the hundreds of types of bacteria that associate with the roots of the model plant Arabidopsis under various conditions.
Nurse's lecture on Great Ideas of Biology will take place at HHMIs Janelia Farm Research Campus on July 31.
With a newly discovered component of an adaptive bacterial immune system, scientists have identified a targeted method of slicing DNA that they say can be easily customized for a variety of applications.
Short strands of piwi-interacting RNA may detect foreign invaders by determining whether a gene has ever been turned on in an organism's past.
Quake is being recognized for his work in drug discovery, genome analysis and personalized medicine.
A new imaging technology developed at Janelia lets users track each cell in an embryo as it takes shape over hours or days.
Thirty years after their discovery, scientists have the first picture of a Wnt protein, a member of a protein family that includes some of the most important regulators of growth and development.
HHMI scientists have determined the three-dimensional structure of two proteins that help keep the bodys clocks in sync.
The three scientists are recognized for elucidating basic neuronal mechanisms underlying perception and decision.
Arthur Horwich and Franz-Ulrich Hartl honored for contributions to the understanding of the molecular mechanism of protein folding.
Using genetic programming, researchers have identified a specific type of cell in the outer layers of the brain that is crucial for Prozac's action.
Researchers lay out evidence for how an unusually efficient enzyme evolved from non-catalytic ancestor proteins.
In the region of the brain that controls motor planning, a self-reinforcing loop of neuronal signaling helps establish connectivity during early development.
Researchers have uncovered the enzyme that transfers phosphate to milk proteins like casein, but also to proteins found in bones and teeth enamel.
Many of the most severe mutations identified in patients with autism affected proteins that work together in one large interconnected network.
As fish in different parts of the world adapted to live in fresh water, the same sites in the genome were changed time and again.
HHMI researchers Thomas M. Jessell and Michael Rosbash honored for significant contributions to medical science.
HHMI seeks to appoint up to 30 new HHMI investigators in 2013. Applications open on March 15, 2012.
Long, ropy fibers were long thought to be the causes of these diseases including Alzheimer's and Parkinsons, but research over the past decade has revealed that fibers arent amyloid proteins' most toxic form.
In a mouse model of Alzheimer’s disease, an overactive enzyme causes memory problems by shutting off genes related to neuronal communication.
Defectos en el gen que codifica para la proteína más grande del cuerpo humano son responsables de más casos de la enfermedad que los causados por todas las otras mutaciones conocidas.