A cellular gatekeeper inside a malaria parasite doesn't care whether the amino acid letters on a protein's entry ticket are out of order.
Researchers studying spinocerebellar ataxia have uncovered a pathological mechanism that may also underlie more common neurological diseases.
HHMI announces a major new program that will provide much-needed support to some of the nation's best early career faculty.
View the complete list of eligible institutions.
Metastatic colon cancers carry the ability to metastasize from the time they become cancerous, and don't need to acquire any new genetic mutations to become metastatic.
A fruit fly's misguided neurons provide a fascinating look at the evolution of systems that detect carbon dioxide.
People who lack a certain large segment of DNA have a previously unrecognized syndrome characterized by mental retardation, seizures, and slight physical abnormalities.
HHMI researchers have developed novel techniques and software that will provide scientists with the tools they need to decipher large-scale patterns in the vital - but little-understood - process of DNA methylation.
Investigadores del HHMI han desarrollado técnicas y software nuevos que les proveerán a los científicos de las herramientas necesarias para descifrar patrones de metilación a gran escala en el vital –pero poco entendido– proceso de metilación de ADN.
Malaria-causing parasites evade the immune system by ducking in and out of cells.
Certain regions inside the nucleus can prevent the genes inside them from becoming activated.
HHMI researchers have uncovered a protein that stops the growth of melanoma.
A new microscopy technique allows researchers to examine the complete three-dimensional morphology of many of the tiniest structures of cells.
Investigadores del HHMI descubren una proteína que detiene el crecimiento del melanoma.
A study that examined the activity of one plant species' 22,000 genes over a complete day and night cycle showed that midnight is a special time that plants can actually distinguish.
HHMI investigators are beginning to examine every gene in the genome to figure out which genes are deleterious to tumor cells.
The birth of new neurons appears to facilitate certain types of complex learning.
HHMI researchers have revealed how a molecule-munching enzyme helps maintains the internal highways found in cells.
The body's immune system can use a surprisingly common molecule to recognize prostate tumors.
Researchers have identified 273 host proteins that serve to keep the AIDS virus healthy and happy as it infects cells.
Researchers have identified small pieces of RNA that suppress the spread of breast cancer to the lungs and bone.
New research has found that many of the symptoms of fragile X syndrome can be eliminated in mice by reducing the expression of a single gene.
Researchers have a new picture of how neurons forge physical connections between one another in order to communicate.
Even short bursts of activity in a few neurons can influence learning and decision making.
New findings help explain how the brain communicates with the inner ear, reducing its response to sound in loud or distracting environments.
Nuevo descubrimiento ayuda a explicar cómo se comunica el cerebro con el oído interno, reduciendo la respuesta al sonido en ambientes ruidosos o que distraen.
Despite a vast evolutionary gulf, humans and the three-spined stickleback fish have adopted a common genetic strategy to acquire the skin pigmentation that helps them thrive.
A team of researchers has exposed how one of the genes most commonly mutated in human cancers helps good cells go bad.
A pesar de la gran brecha evolutiva que existe entre los seres humanos y el pez espinoso de tres espinas, las dos especies han adoptado una estrategia genética común para adquirir la pigmentación de la piel que ayudaría a estas dos especies a prosperar en su nuevo ambiente.
Equipo de investigadores expone la forma en la que uno de los genes que más comúnmente muta en los cánceres humanos puede hacer que las células buenas se conviertan en malignas.
New research shows that normal aging appears to disrupt communication between different regions of the brain.
Nueva investigación muestra que el envejecimiento normal parece interrumpir la comunicación entre distintas regiones del cerebro.
The antidepressant mianserin can extend the lifespan of the the roundworm by about 30 percent.
Structural information about the protein the measles virus uses to attach itself to target cells suggests a strategy to fight infection.
HHMI investigator Dorothee Kern and her colleagues have developed a new picture of how the enzyme adenylate cyclase works.
Información estructural sobre la proteína que usa el virus del sarampión para unirse a sus células dianas podría proporcionar una nueva estrategia para luchar contra la infección.
Researchers have deciphered the molecular language that cholera bacteria use to coordinate their infectivity. By interrupting the bacterium's chemical conversation, researchers may be able to stop cholera virulence.
HHMI researchers are unveiling the most detailed views yet of the structure of a voltage-dependent potassium ion channel.
Unos investigadores han descifrado el lenguaje molecular que las bacterias del cólera utilizan para coordinar su infectividad. Al interrumpir la conversación química de las bacterias, se podría detener la virulencia del cólera.
Researchers have developed a small molecule that can turn the survival signal for a variety of cancer cells into a death signal.
New details emerge about how cells decide their fates when faced with stress.
Researchers have devised a new strategy to fight breast and ovarian cancer.
Scientists have shown how odor-sensing neurons in the worm can activate or inhibit other neurons that control crawling and turning.
New studies reveal that the cancer-promoting gene ras relies on 28 other genes to switch off the cell's programmed cell death pathway.
HHMI researchers discover a clever strategy that helps Legionella pneumophila infect host cells.
HHMI researchers have now discovered a protein that can affect how DNA is packaged inside sperm.
A worldwide network of more than 150,000 home computer users helped HHMI researchers predict the structure of a small, naturally occurring protein.
The brain may continue to consider the options even after a decision is made, leaving room for a change of mind.
New study suggests that each breast and colon tumor is unique and may arise through mutations in many different combinations of genes.
HHMI announces the selection of 15 of the nation's top patient-oriented researchers, who will soon become HHMI investigators.