Researchers have discovered a molecular master switch that triggers the genetic overhaul plants need to fight off pathogens.
The gene mutation that causes retinoblastoma changes the way cells turn on and off many other genes.
Researchers have discovered how plants regulate the development of the pores through which critical exchanges of water and carbon dioxide occur.
By resurrecting the ancient forms of a molecular machine, scientists have learned how simple evolutionary processes can produce the complex assemblies of molecules that allow modern cells to function.
New research shows that fluoride has dramatic effects on bacteria inside the mouth.
Sean B. Carroll, HHMI’s vice president for science education and a long-time HHMI investigator, has been awarded the 2012 Benjamin Franklin Medal in Life Science.
Scientists have pinpointed the gene responsible for a disease that causes seizures in infancy and sudden, uncontrollable movements in adolescence and early adulthood.
Studies of fragile X syndrome and tuberous sclerosis show that for brain cells to function normally, neural synapses must produce just the right amount of protein.
By activating regions of the brain linked to food-related pleasure, scientists are learning how the brain mediates the link between food preferences and hunger.
A group of internationally recognized scientists was named to the editorial team of eLife, the new open-access journal to be launched by HHMI, Wellcome Trust and Max Planck Society.
Blood vessels in the lungs produce signals that activate the regeneration of alveoli—the tiny cavities through which blood takes in oxygen and releases carbon dioxide.
The fruit-fly protein Zelda helps govern the developmental handoff from mother's influence to an animal's own genome.
Fruit flies integrate smell and visual information to fine-tune flying behavior.
Seven HHMI investigators are among the 65 new members announced today.
New HHMI research shows that reactivating fetal hemoglobin production in adult mice effectively reverses sickle cell disease.
Nueva investigación del HHMI muestra que la reactivación de la producción de hemoglobina fetal en ratones adultos revierte eficientemente la enfermedad de células falciformes.
At least 100 trillion bacteria live in the mammalian gut. How can we carry all those organisms and not get sick?
HHMI scientists have identified a cellular pathway that may be key to sparking growth of pancreatic beta cells in mice and humans.
HHMI will unveil three short science films that use vivid storytelling to teach the vital concepts of adaptation and natural selection.
Patterson, director of publishing at the Public Library of Science (PLoS), helped establish PLoS as a pioneer of open access publishing.
Neurobiologist Leslie Vosshall will discuss why mosquitoes bite some people and not others at a lecture on November 9. The event is free and open to the public.
New research pinpoints a biological barrier that has thus far slowed progress in creating disease-specific stem cell lines using a technique known as nuclear transfer.
Dietary folic acid helps prevent a subset of neurological birth defects in humans. Now, researchers have found that certain genetic mutations in mice that mimic these birth defects do not respond to a diet enriched with folic acid.
In the last 18 months, Janelia Farm has recruited two group leaders, four fellows and four junior fellows.
In one region of the human brain, new cells are generated only until 18 months of age.
Award-winning writer and producer David Elisco has been named director of development for the Howard Hughes Medical Institute’s new film production unit.
Most of the neurons in the VNO, a sensory organ long assumed to be primarily devoted to pheromone detection, are dedicated to the detection of animals from other species.
Human evolution—one of the most discussed scientific topics and one of the hardest for teachers to tackle—will be the focus of the 2011 Holiday Lectures on Science from HHMI.
A new study in fruit flies suggests that DEET confuses insects by jamming their odor receptors.
New studies highlight promising vaccine strategies to prevent malaria parasites from causing illness and death.
Horwich and Franz-Ulrich Hartl share the 2011 Albert Lasker Basic Medical Research Award for key discoveries that elucidate steps in protein folding.
Scientists have identified a genetic regulator that controls the reshuffling of gene segments in immune cells.
Beachy is being honored for his work on Hedgehog, a key molecule in development.
HHMI researchers have developed a potential TB vaccine that completely eliminates tuberculosis bacteria from infected tissues in some mice.
Distinct areas of the brain process sweet, bitter, salty, and umami tastes.
Designer ion channels that can turn neurons on or off will help researchers understand the connection between behavior and neural circuitry.
The first definitive proof of a weak spot in the parasite's apicoplasts—organelles with ancient plant origins—offers hope for drugs and vaccines against malaria.
New research has classified vertebrate evolution in relation to periods of evolution marked by changes in specific kinds of genes.
Protective chemicals known as interferons may identify themselves by how tightly they grip their receptor at various attachment points.
An HHMI-funded researcher has used online gene expression profiles to match old drugs with diseases in need of treatments.
Next-generation sequencing and stem cell technology have helped scientists identify a mutation that causes retinitis pigmentosa.
Understanding of antibody may help scientists design a longer-lasting vaccine against the influenza virus.
A new fellowship program will enable 48 graduate students from 22 countries to devote their full attention to research at a critical time during their professional development as scientists.
Nuevo programa de becas permitirá que 48 estudiantes de postgrado de 22 países dediquen toda su atención a la investigación en un momento crítico de su desarrollo profesional como científicos.
A test that detects a cancer-causing fusion gene in men’s urine could help reduce the number of prostate biopsies performed each year.
Two studies reveal genetic mutations often present in the most common form of head and neck cancer, offering a picture of how the cancer develops and how therapeutics could treat it.
A genetic comparison of E. coli strains, including the one responsible for the recent outbreak of infections in Europe, underscores how rapidly evolving bacterial genomes can lead to the emergence of new pathogens.
Altering the balance of excitatory and inhibitory inputs in the brains of mice disrupts the animals' social interactions.
The neurological problems caused by Fragile X syndrome may be due to excess synthesis of certain proteins.
An immune defense protein uses prion-like qualities to fend off viruses.