New research adds to growing evidence that Parkinson's disease may arise in part from neurons’ failure to recycle the materials used to package and transport neurotransmitters.
HHMI scientists develop a much-needed genetic resource that is aiding development of wheat plants with improved traits.
HHMI investigators Stephen Elledge, Roel Nusse and Huda Zoghbi are among the scientists honored for transformative advances toward understanding living systems and extending human life.
HHMI researchers identify the mechanisms that pathogenic bacteria use to waterlog the space between plant cells in the leaves, allowing the bacteria to reproduce and spread infection.
Janelia scientists have developed the first adaptive light-sheet microscope — an instrument that continuously analyzes and adapts to dynamic changes in a specimen and thereby improves spatial resolution.
HHMI researchers find that a gene that blocks the differentiation of pigment-producing cells in the skin of the African striped mouse helps in generating the mouse’s characteristic light-colored stripes.
The first unbiased genetic screen for sleep defects in mice yields two interesting mutants, Sleepy, which sleeps excessively, and Dreamless, which lacks rapid eye movement sleep.
Janelia scientists are learning how animals adjust their physical exertion as changes in the environment or their own bodies alter how efficiently they move.
A new viral vector will help scientists understand large-scale neural networks.
HHMI researchers have learned to program T cells as if they were "microscopic robots" -- to sense inputs and to respond.
Lasker Award honors research showing how cells from humans and most animals sense and adapt to changes in oxygen availability.
Janelia scientists have identified a gene that causes male Drosophila to produce different courtship songs.
Using novel computational and biochemical approaches, HHMI scientists have designed and built from scratch 10 large protein icosahedra that are similar to viral capsids that carry viral DNA.
International research team unveils new data describing the interaction between genetic and epigenetic variation in Arabidopsis thaliana.
Janelia scientists find that a molecule best known for its role in pain perception also plays an important role in regulating body weight.
HHMI scientists have pioneered the use of genome editing to trace lineage in living systems.
Researchers have discovered that fat tissue is a previously unrecognized reservoir of trypanosomes, the parasites that cause sleeping sickness.
HHMI scientists have designed a potential cancer therapy that uses a unique strategy to block a molecule that drives the growth of cancer.
New experiments help explain how the brain speeds up or slows down movement.
Analyses of ancient DNA from prehistoric humans paint a picture of dramatic population change in Europe from 45,000 to 7,000 years ago.
On May 18, Michael Kennedy will deliver a talk, “The Power of Community: Improving STEM Futures for Urban Youth” at 7:00 p.m. at Janelia Research Campus
New research from Janelia scientists suggests the brain is organized into modules that work together to maintain critical functions, even in the face of disturbances.
HHMI scientists have discovered a command center in the brain that controls how much insects eat and how quickly they consume their food.
HHMI, the Bill & Melinda Gates Foundation, the Wellcome Trust, and the Calouste Gulbenkian Foundation announce the International Research Scholars Program which aims to support up to 50 outstanding early career scientists worldwide.
In only the second time in history, all five Canada Gairdner International Awards are being given to one topic -- CRISPR-Cas technology.
HHMI scientists identify a region of the brain that is critical in translating danger signals detected by the nose into physiological responses.
Janelia announces the establishment of the neuronal cell biology program and recruitment of the first group leaders.
HHMI scientists identify a gene that might serve as a molecular link between mood and the circadian clock.
HHMI researchers have identified 27 genes in brain stem cells that are prone to a type of DNA damage called double-strand breaks.
New study suggests why mice with cystic fibrosis mutations can stave off bacterial infections in their lungs.
New experiments at HHMI's Janelia Research Campus show that activity in the cortex is critical for enacting a learned skill.
The MouseLight Project team at Janelia unveils a microscope and method for long-range tracing of neurons in the mouse brain.
New study suggests that graded changes in gene expression are an organizing principle for CA1 pyramidal cells in the hippocampus.
On February 24, HHMI investigator Bonnie Bassler will deliver a talk, “Tiny Conspiracies: Cell-to-Cell Communication in Bacteria,” at 7:00 p.m. at Janelia Research Campus.
Research uncovers new information about the biological processes that help ensure that two fly species don't interbreed.
HHMI researchers have discovered a molecular mechanism that enables plants to detect when they are in the shade of other plants and adapt by speeding up their growth.
Using an advanced imaging system with adaptive optics, Janelia scientists have uncovered new details about how the brain processes visual information.
New research examines why some children born with heart defects also have developmental disabilities.
Researchers learn more details about how CRISPR works in cells.
Scientists show they can control whether mice perceive a taste as bitter or sweet by activating two small areas of the brain.
HHMI investigators Karl Deisseroth and Helen Hobbs are among five scientists honored for transformative advances toward understanding living systems and extending human life.
HHMI scientists have identified a set of proteins that plays a surprisingly broad role in guiding tissue formation in plant roots.
Within less than a second, the new IsoView microscope produces images of entire organisms, such as a zebrafish or fruit fly embryo, with enough resolution in all three dimensions that each cell appears as a distinct structure.
HHMI's Paul Modrich shares 2015 Nobel Prize in Chemistry with Tomas Lindahl and Aziz Sancar for studies of DNA repair.
New research indicates individual human neurons may harbor up to 1,000 genetic mutations.
HHMI Investigator Stephen Elledge of Brigham and Women's Hospital shares the 2015 Albert Lasker Basic Medical Research Award with Evelyn Witkin of Rutgers University.
New imaging methods dramatically improve the spatial resolution provided by structured illumination microscopy, one of the best imaging techniques for seeing inside living cells.
HHMI scientists have discovered how the most common genetic defect in amyotrophic lateral sclerosis kills nerve cells.
HHMI researchers solve a longstanding mystery about the origin of new cells in the liver.
A lipid molecule called EET helps blood-forming stem cells replenish the immune system.