The human immune system can recognize and destroy thousands of invaders. Did this diversity come about accidentally when a mobile piece of DNA inserted itself into the mammalian genome more than 450 million years ago?
Researchers discover new details about how cells monitor the signals that stimulate proliferation or shut down cell growth. Such signals can turn a normal cell into one that grows uncontrollably, the first step in the development of cancer.
A powerful, award-winning video that encourages minority students to pursue careers is now available on the Web.
Meeting Features Leading Biomedical Scientists From Central Europe, Former Soviet Union and the Baltics
Salt is poison for people with high blood pressure. Genetic studies are beginning to clarify who is at risk and why.
Scientists Determine Structure of HIV-1 Protein that Grasps Human Cells.
Researchers have identified a faulty conduit into nerve cells that causes them to fire uncontrollably, triggering the brief seizures that characterize some forms of epilepsy.
eCircadian clocks maintain the sleep-wake cycle for a 24-hour day in a variety of organisms. Two HHMI researchers and their colleagues have discovered more of the clock's molecular components.
Hughes investigators have discovered a family of packemaker ion channels that power the heart and the brain
Knockout mice point the way to a new theory of how a ubiquitous protein may promote heart disease.
The Institute plans to award $12 million in new grants for precollege science programs at biomedical research institutions.
Jeremy R. Knowles, Dean of the Harvard University Faculty of Arts and Sciences, has been elected a Trustee of the Howard Hughes Medical Institute.
HHMI researchers have discovered a genetic mutation that damages heart muscle so that it dilates to the point where the heart can no longer pump blood.
Familial hypertrophic cardiomyopathy is the most common underlying cause of sudden cardiac death in young athletes. New research suggests the disorder may be more widespread than previously thought.
Hughes investigators have discovered that a compound produced by the ocean-dwelling sponge Haliclona shuts down the ubiquitous cellular motor proteins that power cell division and a variety of other processes.
For nearly 50 years, scientists have wondered what a potassium channel looks like. Now, an HHMI research team at The Rockefeller University unveils the channel's surprising architecture.
Spontaneous neural activity in the developing brain is necessary to help organize the detailed connections that exist in the visual system.
Recent research may help clarify whether type 2 diabetes is caused by errant genes or faulty biology.
New Web site provides 'one-stop shopping' for young researchers seeking fellowships, grants.
How does a virus inactivate a tumor suppressor protein? Hughes researchers have crystallized one key tumor suppressor in the act of being handcuffed by a fragment of the human papilloma virus.
Impact of Market Changes on Medical Research and Training to be Considered at Conference at HHMI on February 23-24
The discovery of two nerve cell hormones and their receptors may help explain how the brain senses hunger signals and responds by increasing appetite.
Hughes investigators have identified two of the Ebola virus's main targets in the human body. They are now working on a vaccine against Ebola virus that primes the immune system to ward off the virus.
Three teams of Hughes researchers are closer to understanding how axons, the long projections of nerve cells, grow toward and across an organism's midline to wire up both sides of the body.