Hughes investigators have discovered a family of packemaker ion channels that power the heart and the brain
Knockout mice point the way to a new theory of how a ubiquitous protein may promote heart disease.
The Institute plans to award $12 million in new grants for precollege science programs at biomedical research institutions.
Jeremy R. Knowles, Dean of the Harvard University Faculty of Arts and Sciences, has been elected a Trustee of the Howard Hughes Medical Institute.
HHMI researchers have discovered a genetic mutation that damages heart muscle so that it dilates to the point where the heart can no longer pump blood.
Familial hypertrophic cardiomyopathy is the most common underlying cause of sudden cardiac death in young athletes. New research suggests the disorder may be more widespread than previously thought.
Research to improve vaccines for infectious diseases must move forward. At the same time, according to HHMI investigator Barry Bloom, scientists should be perfecting vaccines that tackle pathogens associated with other diseases, such as cancer and heart disease.
Hughes investigators have discovered that a compound produced by the ocean-dwelling sponge Haliclona shuts down the ubiquitous cellular motor proteins that power cell division and a variety of other processes.
For nearly 50 years, scientists have wondered what a potassium channel looks like. Now, an HHMI research team at The Rockefeller University unveils the channel's surprising architecture.
Spontaneous neural activity in the developing brain is necessary to help organize the detailed connections that exist in the visual system.
Recent research may help clarify whether type 2 diabetes is caused by errant genes or faulty biology.
New Web site provides 'one-stop shopping' for young researchers seeking fellowships, grants.
How does a virus inactivate a tumor suppressor protein? Hughes researchers have crystallized one key tumor suppressor in the act of being handcuffed by a fragment of the human papilloma virus.
Impact of Market Changes on Medical Research and Training to be Considered at Conference at HHMI on February 23-24
The discovery of two nerve cell hormones and their receptors may help explain how the brain senses hunger signals and responds by increasing appetite.
Hughes investigators have identified two of the Ebola virus's main targets in the human body. They are now working on a vaccine against Ebola virus that primes the immune system to ward off the virus.
Three teams of Hughes researchers are closer to understanding how axons, the long projections of nerve cells, grow toward and across an organism's midline to wire up both sides of the body.
HHMI researchers have determined the three-dimensional structure of a protein-RNA complex that shepherds the production of infectious copies of HIV. The structure is a promising target for new antiviral drugs. Article published in the January 16, 1998 issue of Science.
Researchers suspect that a combination of genes and environment determine one's susceptibility to allergic conditions. Hughes researchers and colleagues at Washington University have identified a mutant protein that may cause hypersensitivity to common allergens.
HHMI physician postdoctoral fellow Michael Yaffe and his colleagues have demonstrated a new mechanism that governs chaperone activity and affects the vitality of cells.
HHMI predoctoral fellow develops a computer program that offers a quick, easy and free way to produce restriction maps of DNA sequences.
Benjamin Doranz, an HHMI predoctoral fellow, is helping to devise a gene therapy technique that could destroy the hidden, latent reservoir of HIV-infected cells that escape drug therapy. Article published in the November 21 issue of Science.
HHMI international scholar B. Brett Finlay hopes to learn exactly how E. coli adheres to target cells - and to improve the treatment of diarrheal diseases.