HHMI investigator Michael J. Welsh's research team has found that the airways of CF patients lack a natural substance that kills bacteria.
Hughes investigator Ronald D. Vale's research provides fresh insight into the structure and operation of the motor proteins that convert chemical energy in the cell into physical movement.
Experiments by Marc Caron and colleagues reveal the importance of the dopamine transporter in conditions such as addiction, schizophrenia and Parkinson's disease.
The discovery of a common genetic circuit for limb formation in arthropods is not only important for developmental biology, but also holds promise as an important new window to the past.
The Institute's Trustees accepted Helen K. Copley's resignation at their November meeting. Copley was one of the original group of Trustees appointed by the Delaware Court of Chancery in 1984.
Genes and partial gene sequences are being found at a rate far faster than anyone can decipher their function. Two groups of Hughes researchers have been attacking that bottleneck with automated programs designed to shed light on the function of newly found genes and the expression patterns of known genes.
Peter S. Kim, an HHMI investigator at the Whitehead Institute for Biomedical Research, believes that the coiled-coil structure of a protein may provide HIV with the spike it needs to infect cells.
James A. Baker, III, secretary of state under George Bush and secretary of the treasury under Ronald Reagan, has been elected a Trustee of HHMI.
HHMI investigator Kevin P. Campbell, HHMI associate Franck Duclos and University of Iowa College of Medicine M.D./Ph.D. student Leland Lim have identified a new form of muscular dystrophy and developed a screening test to detect carriers of the disease.
Daniel E. Goldberg and colleagues have discovered how the malaria parasite is able to safely sidestep a poison in hemoglobin, its main food source.
HHMI Investigator Ronald M. Evans has found a new hormone that triggers cells to become fat cells.
A team of U.S. and Finnish scientists led by HHMI investigator, David Page, has found that a specific defect in the Y chromosome may be responsible for 13 percent of cases of azoospermia, the inability to make sperm and the most severe form of male infertility.
A research group headed by HHMI investigator Richard D. Palmiter at the University of Washington has shown conclusively that catecholamines are essential in mouse development, and most likely in human development, too.
Leptin administered to overweight mice during two weeks of treatment caused the mice to decrease food intake and increase energy expenditure.
A team of U.S. and Finnish scientists has found that a specific defect in the Y chromosome may be responsible for 13 percent of cases of azoospermia, the inability to make sperm and the most severe form of male infertility.
Christine and Jonathan Seidman have developed a mouse model of familial hypertrophic cardiomyopathy that should greatly enhance genetic studies of this deadly disease.
The following remarks were made by Hungarian researcher László Hunyady of Semmelweiss University of Medicine in Budapest. He was addressing diplomats and journalists at a luncheon announcing the Hughes grants that was held in July at HHMI's headquarters outside of Washington, D.C.