Hyock Joo Kwon has helped to determine the structure of the active site of bacteriophage lambda integrase, a well-studied protein that had proven difficult to visualize.
Stephen Blacklow, a former HHMI postdoctoral fellow, has made a discovery that may explain why some people have high cholesterol levels
Jeffrey M. Friedman and colleagues report that the weight-reducing effects of the hormone leptin result from interaction with a receptor in the brain's hypothalamus and other tissues.
Graeme Bell and other researchers have found a gene that may make people susceptible to type II diabetes.
A team of HHMI scientists has peered deep inside HIV-1 for a closer view of the fragile shell that envelops the virus' genetic material.
Dan Littman and fellow researchers have found a receptor for HIV that appears to play a key role in the transmission of the virus between individuals.
Michael Naski has helped to identify a genetic mutation that can cause bones to stop growing, leading to a form of dwarfism.
HHMI researchers have learned that basal cell carcinoma is caused by a defect in a gene that restrains cell growth.
HHMI scientists at the University of Texas Southwestern Medical Center are blocking the enzyme telomerase in a new strategy to prevent cancer cells from dividing.
Don Ganem's decision to search for a viral cause for Kaposi's sarcoma was considered risky by many molecular biologists.
Sharon Long's studies of signal transduction pathways in plants could yield insights into cancer and other diseases in humans.
Hughes researchers have developed a technique that may speed the identification of more tumor suppressor genes.
International research scholar Alec Jeffeys believes that radiation leaked from Chernobyl more than a decade ago may only now be manifesting its diastrous legacy.
Students at Texas Tech University are co-authors on a Nature paper showing a high rate of genetic change in rodents living near the Chernobyl reactor.
HHMI investigator Michael J. Welsh's research team has found that the airways of CF patients lack a natural substance that kills bacteria.
Hughes investigator Ronald D. Vale's research provides fresh insight into the structure and operation of the motor proteins that convert chemical energy in the cell into physical movement.
Experiments by Marc Caron and colleagues reveal the importance of the dopamine transporter in conditions such as addiction, schizophrenia and Parkinson's disease.
The discovery of a common genetic circuit for limb formation in arthropods is not only important for developmental biology, but also holds promise as an important new window to the past.
Genes and partial gene sequences are being found at a rate far faster than anyone can decipher their function. Two groups of Hughes researchers have been attacking that bottleneck with automated programs designed to shed light on the function of newly found genes and the expression patterns of known genes.
Peter S. Kim, an HHMI investigator at the Whitehead Institute for Biomedical Research, believes that the coiled-coil structure of a protein may provide HIV with the spike it needs to infect cells.