Studies of a molecule that causes severe weight loss in cancer patients may yield new drugs to treat obesity.
Two HHMI labs discover a new molecular road sign that directs axons to their proper destination in the central nervous system.
HHMI researchers find that the mahogany protein suppresses obesity and plays a role in the immune system.
With odorant receptor genes from Drosophila in hand, researchers hope to learn how odors influence behavior.
How does the nose discriminate between different odors?
HHMI researchers have developed a versatile method for improving binding properties of potential drugs.
HHMI researchers have identified a gene that influences formation of the chambers of the heart.
Mouse geneticists get a boost with the release of an encyclopedia containing more than 360,000 genetic sequences.
By studying flies that have mutations similar to some cancer patients, HHMI researchers have found a new type of tumor suppressor gene.
Dopamine transporter knockout mice developed by HHMI investigator Marc Caron and colleagues have provided a wealth of information about the molecular nature of some behavioral disorders.
By tricking HIV into showing more of itself than usual, researchers have produced antibodies that neutralize many infective strains of the virus.
A human cell surface protein that maintains the structural integrity of tissues is also the portal of entry for bacteria and viruses.
HHMI investigators have produced an image of the active form of the HIV enzyme reverse transcriptase. This work may clarify how mutations render HIV resistant to antiviral drugs.
A team of scientists from the Howard Hughes Medical Institute at the University of Chicago has found that a ubiquitous protein may explain how relatively sudden changes in body shape occur in a species.
Un equipo de científicos del Instituto Médico Howard Hughes en la Universidad de Chicago ha encontrado que una ubicua proteína puede explicar cómo se llevan a cabo los cambios relativamente repentinos en la forma del cuerpo de una especie.
The most common genetic cause of infant mortality happens because cells cannot properly process messenger RNA. The search for drugs to correct this defect is underway.
HHMI investigators have found a cellular target of survival signals that can override programmed cell death.
Genetic studies have uncovered a host of new genes involved in the formation of spores in yeast. The studies may illuminate germ cell production in vertebrates.
HHMI researcher Leonard Zon leads a team that has cloned a zebrafish anemia gene, producing one of the first fish models of a human disease. The achievement opens a new avenue for studying the genetics of human diseases.
HHMI researchers show that ribozymes and enzymes are ready to perform their biological function as soon as they are produced.
The tumor suppressor p16 normally holds the growth-promoting molecule Cdk6 in check. New structural insights may explain how Cdk6 slips free from p16, promoting cancer development.
HHMI researchers produce the first glimpses of the molecular machinery that propels neurotransmitters into the synapse.
HHMI investigators have found another molecular landmark that points growing neurons to their proper destination in the brain or spinal cord.
Researchers report the first hard evidence that most cases of colon cancer arise when mutations in a genetic "master brake" help to switch on a well-known cancer-promoting gene.
Researchers used to identify important developmental genes one at a time. Now, a technique developed in Drosophila is taking wing, and hundreds of novel genes have been found.