The biological basis of schizophrenia is not fully understood, but new research by HHMI international research scholar Michael Salter offers insights into the disruptions in brain chemistry that underlie the debilitating mental illness.
Using chemical genetics to single out a single kinase among the hundreds inside a cell, scientists have gleaned new information about how one such protein might contribute to cancer-promoting signaling.
New maps detailing where certain markers of genetic regulation are found in a variety of cell types will help researchers interpret large-scale analyses.
A zebrafish model of human melanoma has helped scientists identify new targets for potential therapies.
New research offers a genetic explanation for why some patients' lung tumors disappear almost completely when treated with the drug erlotinib, while other patients' responses are far less dramatic.
Searching for a new food source is a big decision for a worm, based on hunger, dining companions, oxygen availability, and, according to a new study, genetics.
The 2011 prize honors Elaine Fuchs, James Thomson, and Shinya Yamanaka for pioneering work in isolating human stem cells.
Flickering black and white movies show components of the spliceosome coming and going from bits of RNA as they await processing.
The clear and watery substance that bathes the brain and spinal cord is enough to support the growth of neural stem cells in the lab.
Specific traits that distinguish humans from their closest living relatives can be attributed to the loss of chunks of DNA that control when and where genes are turned on.
With the flick of a genetic light switch, researchers have reduced symptoms of anxiety in laboratory mice.
A new genetic method for labeling cells transforms the tangles of neurons within the brain of a fruit fly into fantastic rainbows of color.
Janelia researchers create a new microscope that uses a thin sheet of light to reveal the dynamic inner life of cells.
Triple-negative tumors lack three traits that can be targeted by available breast cancer treatments. But new findings suggest treatment possibilities for these aggressive cancers may be at hand.
A newly identified genetic marker appears to predict a diagnosis of post-traumatic stress disorder in women, but not in men.
A rapid new method of blocking gene function is letting researchers dissect how stem cell progenitors in the skin split their energy between creating copies of themselves and crafting specialized new cells.
A corrective strategy used by astronomers to sharpen images of celestial bodies can now help scientists see with more depth and clarity into the living brain of a mouse.
Scientists have used next-generation DNA sequencing tools to identify a mutation in a gene that underlies one of the most common forms of severe hypertension.
Neurons that control aggression and mating are closely intertwined deep within the brain.
Researchers gain a new view of how genes are converted to protein by freezing the action during the earliest stage of the process.
Researchers at Stanford University have discovered that they may be able to tweak cancer cells so that they summon their own demise.
In mice with light-sensitive neurons in their brain, illuminating one type of neuron drives the animals to their food bowls, whereas targeting a different type makes them abstain.
After a rapid genetic analysis of bacteria collected from Haitian patients, scientists conclude that the strain of cholera currently sweeping through post-earthquake Haiti originated in South Asia.
HHMI has launched an international competition to select up to 35 early career scientists working at academic institutions in 18 countries on five continents.
A study in fruit flies shows that turning back the clock on aging muscles delays aging in the whole animal.