HHMI investigator Michael J. Welsh's research team has found that the airways of CF patients lack a natural substance that kills bacteria.
Hughes investigator Ronald D. Vale's research provides fresh insight into the structure and operation of the motor proteins that convert chemical energy in the cell into physical movement.
Experiments by Marc Caron and colleagues reveal the importance of the dopamine transporter in conditions such as addiction, schizophrenia and Parkinson's disease.
The discovery of a common genetic circuit for limb formation in arthropods is not only important for developmental biology, but also holds promise as an important new window to the past.
Genes and partial gene sequences are being found at a rate far faster than anyone can decipher their function. Two groups of Hughes researchers have been attacking that bottleneck with automated programs designed to shed light on the function of newly found genes and the expression patterns of known genes.
Peter S. Kim, an HHMI investigator at the Whitehead Institute for Biomedical Research, believes that the coiled-coil structure of a protein may provide HIV with the spike it needs to infect cells.
HHMI investigator Kevin P. Campbell, HHMI associate Franck Duclos and University of Iowa College of Medicine M.D./Ph.D. student Leland Lim have identified a new form of muscular dystrophy and developed a screening test to detect carriers of the disease.
Daniel E. Goldberg and colleagues have discovered how the malaria parasite is able to safely sidestep a poison in hemoglobin, its main food source.
HHMI Investigator Ronald M. Evans has found a new hormone that triggers cells to become fat cells.
A team of U.S. and Finnish scientists led by HHMI investigator, David Page, has found that a specific defect in the Y chromosome may be responsible for 13 percent of cases of azoospermia, the inability to make sperm and the most severe form of male infertility.
A research group headed by HHMI investigator Richard D. Palmiter at the University of Washington has shown conclusively that catecholamines are essential in mouse development, and most likely in human development, too.
Leptin administered to overweight mice during two weeks of treatment caused the mice to decrease food intake and increase energy expenditure.
A team of U.S. and Finnish scientists has found that a specific defect in the Y chromosome may be responsible for 13 percent of cases of azoospermia, the inability to make sperm and the most severe form of male infertility.
Christine and Jonathan Seidman have developed a mouse model of familial hypertrophic cardiomyopathy that should greatly enhance genetic studies of this deadly disease.
HHMI researchers at Rockefeller University have discovered a new hormone produced by fat tissue and presumably acting on the brain to regulate weight.
Scientists at the Howard Hughes Medical Institute at Columbia University are turning their attention to proteins that might beckon to the correct DNA target within human cells.
Researchers with the Howard Hughes Medical Institute at Yale University led a team that found the genetic cause at the heart of Liddle's syndrome.
Researchers at the Howard Hughes Medical Institute at the University of Utah have discovered two genes that cause long QT syndrome, an inherited disorder that causes sudden death in young, otherwise healthy people.
Yuet Wai Kan's team at the Howard Hughes Medical Institute at the University of California, San Francisco, has devised a method for delivering a genetic message to tissues and cells displaying the same molecular "address."