For some developmental genes, one allele must stay silent, otherwise debilitating syndromes and cancers can arise. HHMI Investigator Yi Zhang and his colleagues have uncovered a new imprinting mechanism cells use to keep these genes quiet in mice.
Scientists at HHMI’s Janelia Research Campus created comprehensive brain maps linking different groups of neurons to specific behaviors, using a machine-learning program that annotated more than 225 days of videos of flies – a feat that would have taken humans some 3,800 years.
HHMI has selected 24 schools in the first round of the Inclusive Excellence initiative, a program that aims to help increase the capacity of colleges and universities to effectively engage all students so that they can be successful in science, especially undergraduates who enter four-year institutions via nontraditional pathways.
Karl Deisseroth honored with research award for work on the biological basis of psychiatric disorders.
Vale shares $1.2 million award for discovery of molecular motor proteins.
Janelia Research Campus scientists have uncovered new clues about how fruit flies keep track of where they are in the world. Understanding the neural basis of navigation in flies may reveal how humans accomplish similar feats.
In studies with mice, Janelia researchers discovered that to maintain certain short-term memories, the brain’s cortex relies on connections with the thalamus.
HHMI, the Bill & Melinda Gates Foundation, the Wellcome Trust, and the Calouste Gulbenkian Foundation announce the selection of 41 International Research Scholars, early-career scientists poised to advance biomedical research across the globe.
Hypoxia reverses brain damage caused by mitochondrial dysfunction, HHMI team finds. The approach might one day point to new therapies for people with Leigh syndrome and other mitochondrial disorders.
Thirteen HHMI scientists have been elected to the National Academy of Sciences.
The Science Education Alliance is announcing the inclusion of its tenth cohort of 15 institutions in the US, as well as the University of Lagos, Nigeria, and Universidad Autónoma de Nuevo León, Mexico.
The HHMI Medical Research Fellows Program allows exceptional MD, DVM, and DDS students to shift course and conduct rigorous research at top institutions throughout the US.
New HHMI research reveals that adding or deleting chromosomes in cells and animals prompts a wide variety of outcomes. The work could help scientists better understand chromosomal abnormalities in humans.
HHMI Investigator Huda Zoghbi is one of seven scientists honored with prestigious awards from Canada's Gairdner Foundation.
HHMI will appoint up to 20 new biomedical researchers through a national open competition.
New research adds to growing evidence that Parkinson's disease may arise in part from neurons’ failure to recycle the materials used to package and transport neurotransmitters.
The Associated Press and HHMI’s Department of Science Education announce a yearlong collaboration on two pilot projects designed to expand AP’s science journalism.
HHMI scientists develop a much-needed genetic resource that is aiding development of wheat plants with improved traits.
HHMI investigators Stephen Elledge, Roel Nusse and Huda Zoghbi are among the scientists honored for transformative advances toward understanding living systems and extending human life.
HHMI researchers identify the mechanisms that pathogenic bacteria use to waterlog the space between plant cells in the leaves, allowing the bacteria to reproduce and spread infection.
Eight HHMI scientists are among 391 new Fellows of the American Association for the Advancement of Science.
Janelia scientists have developed the first adaptive light-sheet microscope — an instrument that continuously analyzes and adapts to dynamic changes in a specimen and thereby improves spatial resolution.
HHMI researchers find that a gene that blocks the differentiation of pigment-producing cells in the skin of the African striped mouse helps in generating the mouse’s characteristic light-colored stripes.
The first unbiased genetic screen for sleep defects in mice yields two interesting mutants, Sleepy, which sleeps excessively, and Dreamless, which lacks rapid eye movement sleep.
Janelia scientists are learning how animals adjust their physical exertion as changes in the environment or their own bodies alter how efficiently they move.