Mice born without a gene that regulates appetite exhibit unexpected attacks of narcolepsy.
A two-tiered boost to the immune system may allow the body to better fight cancer on its own.
New theories about how neural activity and visual stimuli sculpt the developing visual system.
A newly discovered protein in nerve cells holds enzymes poised for action next to their receptor.
Interferon cures only 20 percent of patients infected with hepatitis C virus. HHMI researchers may know the reason why.
Complex mathematical analysis reveals how potassium is allowed to travel across the cell membrane.
Sons conceived with the aid of a popular in vitro fertilization technique carry same genetic mutations that rendered their fathers infertile.
Molecular studies of a family of genes are pruning branches from the old evolutionary tree.
Genetic studies confirm that one gene mutation plays a major role in inherited deafness; the importance of another genetic mutation is called into question.
HHMI researchers discover a gene responsible for triggering embryonic cells in the inner ear to develop into sound- and motion-sensing hair cells.
HHMI researchers have found a protein whose activity controls the shape of a developing organ.
HHMI researchers have discovered a molecule that resembles a component of snake toxins, but has a dramatically different effect on the nervous system.
Nitric oxide prevents programmed cell death by handcuffing the molecular executioner.
Studies of a molecule that causes severe weight loss in cancer patients may yield new drugs to treat obesity.
Two HHMI labs discover a new molecular road sign that directs axons to their proper destination in the central nervous system.
HHMI researchers find that the mahogany protein suppresses obesity and plays a role in the immune system.
With odorant receptor genes from Drosophila in hand, researchers hope to learn how odors influence behavior.
How does the nose discriminate between different odors?
HHMI researchers have developed a versatile method for improving binding properties of potential drugs.
HHMI researchers have identified a gene that influences formation of the chambers of the heart.
Mouse geneticists get a boost with the release of an encyclopedia containing more than 360,000 genetic sequences.
By studying flies that have mutations similar to some cancer patients, HHMI researchers have found a new type of tumor suppressor gene.
Dopamine transporter knockout mice developed by HHMI investigator Marc Caron and colleagues have provided a wealth of information about the molecular nature of some behavioral disorders.
A human cell surface protein that maintains the structural integrity of tissues is also the portal of entry for bacteria and viruses.
HHMI investigators have produced an image of the active form of the HIV enzyme reverse transcriptase. This work may clarify how mutations render HIV resistant to antiviral drugs.