El HHMI y la Universidad de KwaZulu-Natal en Sudáfrica establecerán un centro de investigación internacional cuyo enfoque es el control de la coepidemia devastadora de la tuberculosis y el VIH.
HHMI and the University of KwaZulu-Natal will establish an international research center focused on controlling the devastating co-epidemic of tuberculosis and HIV.
Una mejor protección podría provenir de una vacuna contra el VIH que haga que el cuerpo produzca un “enjambre” de anticuerpos naturales.
Better protection might come from an HIV vaccine that induces the body to produce a "swarm" of natural antibodies.
Scientists have discovered sensory neurons within the antennae that help flies respond to wind.
Rose, a Senior Lecturer at the Harvard Business School and 20-year veteran of J.P. Morgan and Co., has been elected a Trustee of HHMI.
Small genomes are cheaper to sequence and lack the repetitive "junk" that clutters bigger genomes—but a new study suggests that bigger genomes are better for figuring out how genes are controlled.
Researchers have taken a major step toward developing a better animal model of human AIDS by genetically modifying HIV so that it can infect a species of rhesus monkeys.
Scientists have mapped previously unknown pathways in yeast cells that link the overactivity of a mysterious gene to the death of nerve cells in Parkinson's disease.
A new tool reveals the identity and quantity of every protein produced by a living cell at any given time.
Scott S. Chilton says his broad interest in the arts and athletics, communication and outreach have made him a better science student.
HHMI celebrates the 200th birthday of Charles Darwin.
Researchers have identified a marker present in the urine of patients with prostate cancer that indicates whether the cancer is progressing and spreading.
Investigadores han identificado un nuevo marcador biológico que se encuentra presente en la orina de pacientes con cáncer de próstata que indica si el cáncer está progresando y se está diseminando.
Ryan T. Dosumu-Johnson almost settled into a career at RadioShack, but instead refocused his life on research.
Inspired by her father, a doctor, Marty A. Fernandez hopes to understand what drives diseases like AIDS, malaria, and Alzheimer’s.
Forced to flee his native Africa, Steven Tuyishime now wants to create vaccines to fight malaria, a disease that kills millions there.
For Angelica M. Riestra, community and science go hand in hand. She hopes she can also combine research and community outreach as a microbiology professor some day.
A childhood moving back and forth between Nicaragua and the United States helped Kelly M. Cadenas appreciate and take advantage of her educational opportunities.
Dania Daye is on her way to becoming a physician-scientist-engineer after a difficult childhood in Lebanon.
HHMI is expanding a program to further the graduate science education of talented students from groups traditionally underrepresented in the sciences.
Sacha L. Prashad loves studying stem cells, which she says provide just the right combination of research and connection to the clinic.
Krystal R. St. Julien's struggle with sickle cell anemia inspired her to become a biochemist.
Meet the 2009 Gilliam Fellows.
HHMI researchers and their colleagues unveil the first comparative map of four primate genomes.
Blood platelets can destroy deadly malaria parasites. But a single dose of aspirin may be enough to thwart their killing power.
Nuevos estudios en ratones sugieren que las plaquetas sanguíneas pueden destruir los mortales parásitos de la malaria. Pero una única dosis de aspirina puede interferir con las plaquetas de forma suficiente como para impedir su poder letal.
The shapes of some of the tiniest cellular structures are coming into sharper focus at Janelia Farm, where scientists have developed a new imaging technology that produces the best three-dimensional resolution ever seen with an optical microscope.
Rajesh Gokhale has created a compound in his lab in India that stops tuberculosis by hitting four of the bacterium's crucial metabolic pathways at the same time.
Researchers have discovered a new form of cellular memory that appears to help immune cells "learn" from past encounters with pathogens so they can combat them more effectively the second time around.
Researchers have created an efficient way to detect genes that have been inappropriately fused together, a type of genetic abnormality that spurs the growth of blood and prostate cancers.
A novel kind of odor-detecting protein may explain some of the gaps in researchers' knowledge of how insects smell.
Una nueva clase de proteínas de detección de olores puede explicar algunas de las lagunas en el conocimiento que tienen los investigadores sobre cómo los insectos detectan los olores.
Twelve new colleges and universities have been chosen to join the Science Education Alliance's nationwide experiment–teach science to students by involving them in scientific discovery.
Hace un año, 12 universidades confiaron en la Alianza de Educación Científica del Instituto Médico Howard Hughes al unirse a un experimento de educación con una ambiciosa agenda –enseñar ciencia a estudiantes involucrándolos en descubrimientos científicos a una escala nacional–. Ahora 12 universidades adicionales han sido elegidas para unirse a la Alianza.
HHMI researchers track down the genes responsible for establishing the characteristic swirl of a snail shells.
A new microscopy technique that uses the principles underlying holography is helping researchers speed up imaging and optically manipulate living cells.
HHMI will award up to $25 million for a unique program that prepares scientists to translate laboratory discoveries into new medical treatments.
New ways of imaging sugar molecules are creating a vibrant new biological frontier.
A 20 year search has helped international research scholar Hugo D. Luján explain how the Giardia parasite hides from the immune system.
Al igual que una pandilla de bandidos que se cambia la ropa después de un robo para evitar ser capturados, el parásito intestinal Giardia lamblia altera su aspecto para engañar al sistema inmune humano. Después de una búsqueda de 20 años, experimentos realizados por el Becario Internacional de Investigación del Instituto Médico Howard Hughes, Hugo D. Luján, revelan cómo cambia sus disfraces el parásito.
Starved cone cells in the eye may nibble themselves to death in people with retinitis pigmentosa.
Una de las razones por las que mueren las células responsables de la visión de los colores en personas con retinitis pigmentosa puede ser que las células se comen a sí mismas cuando son privadas de nutrientes.
At least one of every four melanoma cells has the capacity to seed the development of new tumors.
By manipulating a newly identified regulatory protein, researchers can reactivate a dormant fetal hemoglobin gene--possibly with therapeutic benefits for patients with life-threatening anemias.
Scientists have created a new mouse model that may help explain how a rare disease causes otherwise supple soft tissue and joints to turn into bone.
HHMI researchers have uncovered a molecular explanation for the profound fatigue brought on by mild exercise in some people with muscular dystrophy.
Researchers have identified a molecule that tells your brain when it's time to say no to a second piece of pie and push back from the Thanksgiving table.
Investigadores identifican una molécula que le dice al cerebro que ha llegado el momento de decirle no a un segundo pedazo pastel de calabaza y alejarse de la mesa del Día de Acción de Gracias.
Susan Lindquist believes that if “personalized medicine” for complex neurodegenerative disorders is to become a reality then scientists must begin developing more rigorous approaches to identifying and validating promising new therapies.
Images in biology textbooks may give the misleading impression that the cell membrane is a passive envelope that does little more than keep the cell’s internal contents in place. Howard Hughes Medical Institute researcher Douglas C. Rees prefers to think of the outer membrane of human cells as a dynamic boundary that sends and receives vital information about the state of affairs inside and outside the cell.
Ants first marched into Danny Reinberg’s world about four years ago as he began thinking about taking his lab in a new direction. Now, he cannot keep ants off his mind because they are the focal point of a newly funded HHMI Collaborative Innovation Award to study whether epigenetics influences the behavior and aging of ants.
In mammals, cells carry out their work driven by two copies of nearly every gene, one inherited from each parent. If something happens to one gene, the other is usually there to compensate. But for a small number of genes, the two copies rule does not apply. For those genes, only one parent’s copy is turned on,and the other is shut off. This regulatory process leaves little room for error because there is no gene to act as a backup if problems arise.
Nearly 70 million people worldwide have glaucoma, an insidious group of diseases that damages the optic nerve and leads to vision loss and blindness. High intraocular pressure, which damages nerve cells in the eye, is one of the biggest known contributing factors in the development of glaucoma.
HHMI broadens its research support with the announcement of a new program to foster collaboration and innovation.
HHMI announces the names of scientists selected to pilot a new program devoted to supporting transformative, collaborative research.
Researchers have traced the sequence of metabolic events that kill E. coli bacteria when they are treated with the antibiotic gentamicin.
New images from HHMI scientists show the stunning dynamics of HIV reverse transcriptase zooming around on the very DNA it is building.
A tiny RNA switch may play a big role in the spread of prostate cancer.
Researchers have discovered three genetic factors that could help doctors identify people who are at the greatest risk for developing a brain aneurysm.
Al escudriñar los genomas de más de 10.000 personas, unos investigadores han descubierto tres factores genéticos que podrían ayudar a que los doctores identifiquen las personas que tienen el mayor riesgo de desarrollar una aneurisma cerebral.
Researchers have developed a method for systematically screening cancer cells to detect genes likely to suppress metastasis.
Researchers have identified the chief motor protein that hauls the building materials needed for learning to their destinations inside neurons.
A new technique factors a protein's flexibility into the drug design equation. It's paying off in a big way.
New technology makes it possible to study tissue samples locked away for decades.
Nueva tecnología hace posible el estudio de muestras de tejidos guardadas por décadas.
Seven HHMI investigators have been elected to the Institute of Medicine.
New studies show how the brain changes when mice learn to feel safe and secure in situations that would normally make them anxious.
Roger Tsien, Osamu Shimomura, and Martin Chalfie honored for the discovery and development of the green fluorescent protein, a ubiquitous research tool.
Roger Tsien, Osamu Shimomura and Martin Chalfie son galardonados por el descubrimiento y desarrollo de la proteína fluorescente verde, que es una herramienta general de investigación.
HHMI researchers devise prenatal blood test that accurately detects Down syndrome and two other serious chromosomal defects.
Investigadores del HHMI desarrollan un nuevo análisis de sangre prenatal que detecta con precisión el síndrome de Down y otros dos defectos cromosómicos serios.
Janelia hosted 14 undergraduate students who worked on research projects under the guidance of research scientists.
HHMI researchers have found microRNAs in animal species whose last common ancestors were present on Earth about 1 billion years ago.
Robert Tjian, a distinguished biochemist and long-time HHMI investigator at the University of California, Berkeley, will become HHMI's next president.
HHMI researchers have developed a new model of cystic fibrosis in pigs that more accurately mimics features of the disease.
Investigadores del HHMI han desarrollado un nuevo modelo de fibrosis quística en cerdos que imita de forma más precisa las características de la enfermedad que se observa en infantes humanos.
Researchers have identified a gene from a new family of ion channels that help to regulate smell and taste sensing, smooth muscle contraction, and fluid secretion in glands and airways.
A newly identified "hot line" connects a worm's nervous system to its immune system.
Investigadores han descubierto una “línea directa” de comunicación que le permite al sistema nervioso de un gusano llamar al sistema inmune para coordinar la respuesta a patógenos infecciosos.
Researchers have learned how Listeria crosses the placenta from mother to baby.
Researchers have devised clever techniques to visualize gene silencing in its natural context.
Professor Alison F. Richard is currently Vice-Chancellor of the University of Cambridge.
DeRisi receives the Heinz Award in Technology, the Economy and Employment.
A gene deletion caused mice to exhibit behavioral and brain changes common in people with Alzheimer's disease or dementia.
Researchers may be able to fight malaria by targeting human liver cells instead of parasites
Las drogas contra la malaria existentes atacan al parásito que causa la enfermedad, pero están perdiendo eficacia debido al aumento en la resistencia a drogas. Investigadores del Instituto Médico Howard Hughes informan que podrían ser capaces de combatir la malaria atacando células humanas hepáticas en lugar de a los parásitos.
A immunosuppressant drug may unexpectedly fight the parasite-caused disease.
Scientists have detected a multitude of broken, missing, and overactive genes in the most detailed genetic survey yet of any human tumor.
Mediante el examen genético más detallado de cualquier tumor humano que se haya realizado hasta el momento, científicos encuentran que en tumores pancreáticos y cerebrales una variedad de genes están rotos, hiperactivos o desaparecen.
Researchers have generated insulin-producing beta cells from adult pancreatic cells in living mice.
Investigadores del HHMI han transformado células pancreáticas adultas en células betas productoras de insulina en ratones vivos.
President Bush named HHMI investigator Robert J. Lefkowitz a recipient of the National Medal of Science for contributions to the biological sciences.