Top biomedical scientists from 12 countries will receive an important boost at a critical time in their careers from HHMI’s inaugural International Early Career Scientist awards.
Perlmutter's lecture on “Building Better Medicines: Drug Discovery in the 21st Century” will take place on February 15.
A breakdown of cellular junk may explain how exercise fends off metabolic disorders and protects against other diseases.
Researchers have discovered a molecular master switch that triggers the genetic overhaul plants need to fight off pathogens.
The gene mutation that causes retinoblastoma changes the way cells turn on and off many other genes.
Researchers have discovered how plants regulate the development of the pores through which critical exchanges of water and carbon dioxide occur.
By resurrecting the ancient forms of a molecular machine, scientists have learned how simple evolutionary processes can produce the complex assemblies of molecules that allow modern cells to function.
New research shows that fluoride has dramatic effects on bacteria inside the mouth.
Sean B. Carroll, HHMI’s vice president for science education and a long-time HHMI investigator, has been awarded the 2012 Benjamin Franklin Medal in Life Science.
Scientists have pinpointed the gene responsible for a disease that causes seizures in infancy and sudden, uncontrollable movements in adolescence and early adulthood.
Studies of fragile X syndrome and tuberous sclerosis show that for brain cells to function normally, neural synapses must produce just the right amount of protein.
By activating regions of the brain linked to food-related pleasure, scientists are learning how the brain mediates the link between food preferences and hunger.
A group of internationally recognized scientists was named to the editorial team of eLife, the new open-access journal to be launched by HHMI, Wellcome Trust and Max Planck Society.
Blood vessels in the lungs produce signals that activate the regeneration of alveoli—the tiny cavities through which blood takes in oxygen and releases carbon dioxide.
The fruit-fly protein Zelda helps govern the developmental handoff from mother's influence to an animal's own genome.
Fruit flies integrate smell and visual information to fine-tune flying behavior.
Seven HHMI investigators are among the 65 new members announced today.
New HHMI research shows that reactivating fetal hemoglobin production in adult mice effectively reverses sickle cell disease.
Nueva investigación del HHMI muestra que la reactivación de la producción de hemoglobina fetal en ratones adultos revierte eficientemente la enfermedad de células falciformes.
At least 100 trillion bacteria live in the mammalian gut. How can we carry all those organisms and not get sick?
HHMI scientists have identified a cellular pathway that may be key to sparking growth of pancreatic beta cells in mice and humans.
HHMI will unveil three short science films that use vivid storytelling to teach the vital concepts of adaptation and natural selection.
Patterson, director of publishing at the Public Library of Science (PLoS), helped establish PLoS as a pioneer of open access publishing.
Neurobiologist Leslie Vosshall will discuss why mosquitoes bite some people and not others at a lecture on November 9. The event is free and open to the public.
New research pinpoints a biological barrier that has thus far slowed progress in creating disease-specific stem cell lines using a technique known as nuclear transfer.
Dietary folic acid helps prevent a subset of neurological birth defects in humans. Now, researchers have found that certain genetic mutations in mice that mimic these birth defects do not respond to a diet enriched with folic acid.
In the last 18 months, Janelia Farm has recruited two group leaders, four fellows and four junior fellows.
In one region of the human brain, new cells are generated only until 18 months of age.
Award-winning writer and producer David Elisco has been named director of development for the Howard Hughes Medical Institute’s new film production unit.
Most of the neurons in the VNO, a sensory organ long assumed to be primarily devoted to pheromone detection, are dedicated to the detection of animals from other species.
Human evolution—one of the most discussed scientific topics and one of the hardest for teachers to tackle—will be the focus of the 2011 Holiday Lectures on Science from HHMI.
A new study in fruit flies suggests that DEET confuses insects by jamming their odor receptors.
New studies highlight promising vaccine strategies to prevent malaria parasites from causing illness and death.
Horwich and Franz-Ulrich Hartl share the 2011 Albert Lasker Basic Medical Research Award for key discoveries that elucidate steps in protein folding.
Scientists have identified a genetic regulator that controls the reshuffling of gene segments in immune cells.
Beachy is being honored for his work on Hedgehog, a key molecule in development.
HHMI researchers have developed a potential TB vaccine that completely eliminates tuberculosis bacteria from infected tissues in some mice.
Distinct areas of the brain process sweet, bitter, salty, and umami tastes.
Designer ion channels that can turn neurons on or off will help researchers understand the connection between behavior and neural circuitry.
The first definitive proof of a weak spot in the parasite's apicoplasts—organelles with ancient plant origins—offers hope for drugs and vaccines against malaria.
New research has classified vertebrate evolution in relation to periods of evolution marked by changes in specific kinds of genes.
Protective chemicals known as interferons may identify themselves by how tightly they grip their receptor at various attachment points.
An HHMI-funded researcher has used online gene expression profiles to match old drugs with diseases in need of treatments.
Next-generation sequencing and stem cell technology have helped scientists identify a mutation that causes retinitis pigmentosa.
Understanding of antibody may help scientists design a longer-lasting vaccine against the influenza virus.
A new fellowship program will enable 48 graduate students from 22 countries to devote their full attention to research at a critical time during their professional development as scientists.
Nuevo programa de becas permitirá que 48 estudiantes de postgrado de 22 países dediquen toda su atención a la investigación en un momento crítico de su desarrollo profesional como científicos.
A test that detects a cancer-causing fusion gene in men’s urine could help reduce the number of prostate biopsies performed each year.
Two studies reveal genetic mutations often present in the most common form of head and neck cancer, offering a picture of how the cancer develops and how therapeutics could treat it.
A genetic comparison of E. coli strains, including the one responsible for the recent outbreak of infections in Europe, underscores how rapidly evolving bacterial genomes can lead to the emergence of new pathogens.
Altering the balance of excitatory and inhibitory inputs in the brains of mice disrupts the animals' social interactions.
The neurological problems caused by Fragile X syndrome may be due to excess synthesis of certain proteins.
An immune defense protein uses prion-like qualities to fend off viruses.
Small bits of RNA can cause a connective tissue cell from human skin to transform into a nerve cell.
Distinguished cell biologist is named first editor of a new journal that HHMI, the Max Planck Society, and the Wellcome Trust will launch next year.
Medical, dental, and veterinary students from 47 schools will be diving into intensive, HHMI-sponsored research experiences this summer at top research centers across the country.
The Howard Hughes Medical Institute, the Max Planck Society, and the Wellcome Trust will support a new journal that will aim to attract and define the very best research publications from across these fields.
A new understanding of a gene that is commonly mutated in people with myeloid leukemia could help lead to new treatments.
Scientists have used a gene therapy tool that acts like intelligent molecular scissors to correct the key gene defect in mice with hemophilia B.
Fifteen scientists working in the plant sciences gain flexible support from HHMI and the Gordon and Betty Moore Foundation to move their research in creative new directions.
The Howard Hughes Medical Institute (HHMI) and the Gordon and Betty Moore Foundation (GBMF) have selected 15 of the nation’s most innovative plant scientists to join a new initiative that boosts much needed funding for fundamental plant science research.
Simon Chan is a 2001 Plant Science Program HHMI-GBMF Investigator.
New research pinpoints differences between cancer stem cells in squamous cell cancer and normal stem cells in the skin, which could be exploited to create powerful new anti-cancer therapeutics.
A new study helps explain how fruit flies commit details of their surroundings to memory.
Medzhitov shares Shaw Prize for discoveries related to innate immunity.
HHMI has launched four-year, $1.8 million science education experiment that will bring together four universities to create and share effective models for teaching interdisciplinary science.
Joanne Chory and Thomas Steitz have been elected foreign members of the Fellowship of the Royal Society.
A detailed comparison of DNA and RNA in human cells has uncovered a surprising number of cases where the corresponding sequences are not, as has long been assumed, identical.
HHMI scientists suggest that as many as 20 percent of sporadic autism cases can be explained by spontaneous gene mutations.
Científicos del HHMI sugieren que tanto como un 20 por ciento de los casos de autismo esporádico pueden explicarse por mutaciones genéticas espontáneas.
A class of proteins known for its involvement in muscle development, brain connectivity, and cancer has now been found in the liver, where it spurs sugar production when we need it most.
Adult planarians, masters of regeneration, harbor pluripotent stem cells that appear to have the same all-purpose qualities as embryonic stem cells.
The same signaling pathway can both cause and suppress disease in blood cells.
Award-winning documentary producer and former president of National Geographic Television will lead HHMI's $60 million science documentary initiative.
New funding from HHMI will be used to scale up a successful summer program that aims to enable thousands of college and university science faculty to receive intensive professional development designed to improve undergraduate biology education.
Six HHMI investigators are among the 72 new members and 18 foreign associates elected today.
With a new animal model of angle-closure glaucoma, researchers have pinpointed a gene that may be to blame.
Human cytomegalovirus hijacks an antiviral protein and uses it to enhance infection by slowing down the host cell’s energy production.
Leonardo's lecture, “Constructing Reality: What Illusions Tell Us About the Mind,” will take place the evening of May 25.
Janelia Farm group leader Mats Gustafsson was a leader in the field of structured illumination light microscopy.
Eight Howard Hughes Medical Institute investigators are among those newly elected to the academy.
New data about what drives aortic aneurysm progression in Marfan syndrome will help guide treatment decisions and inform efforts to develop new therapies.
At any given moment, a few neurons are ready to take charge of the next piece of information to be stored in the brain's hippocampus.
HHMI has invited 215 undergraduate-focused colleges and universities from across the country to apply for a total of $60 million in science education grants.
The biological basis of schizophrenia is not fully understood, but new research by HHMI international research scholar Michael Salter offers insights into the disruptions in brain chemistry that underlie the debilitating mental illness.
Using chemical genetics to single out a single kinase among the hundreds inside a cell, scientists have gleaned new information about how one such protein might contribute to cancer-promoting signaling.
New maps detailing where certain markers of genetic regulation are found in a variety of cell types will help researchers interpret large-scale analyses.
A zebrafish model of human melanoma has helped scientists identify new targets for potential therapies.
New research offers a genetic explanation for why some patients' lung tumors disappear almost completely when treated with the drug erlotinib, while other patients' responses are far less dramatic.
The Trustees of HHMI have elected Nitin Kotak as vice president and chief financial officer. He joins the Institute from Bethesda-based Technest Holdings, Inc.
Searching for a new food source is a big decision for a worm, based on hunger, dining companions, oxygen availability, and, according to a new study, genetics.
The 2011 prize honors Elaine Fuchs, James Thomson, and Shinya Yamanaka for pioneering work in isolating human stem cells.
Flickering black and white movies show components of the spliceosome coming and going from bits of RNA as they await processing.
The clear and watery substance that bathes the brain and spinal cord is enough to support the growth of neural stem cells in the lab.
Specific traits that distinguish humans from their closest living relatives can be attributed to the loss of chunks of DNA that control when and where genes are turned on.
With the flick of a genetic light switch, researchers have reduced symptoms of anxiety in laboratory mice.
A new genetic method for labeling cells transforms the tangles of neurons within the brain of a fruit fly into fantastic rainbows of color.
Janelia researchers create a new microscope that uses a thin sheet of light to reveal the dynamic inner life of cells.
Triple-negative tumors lack three traits that can be targeted by available breast cancer treatments. But new findings suggest treatment possibilities for these aggressive cancers may be at hand.
Gloria Tavera is a 2011 Gilliam Fellow.