Searching for a new food source is a big decision for a worm, based on hunger, dining companions, oxygen availability, and, according to a new study, genetics.
The 2011 prize honors Elaine Fuchs, James Thomson, and Shinya Yamanaka for pioneering work in isolating human stem cells.
Flickering black and white movies show components of the spliceosome coming and going from bits of RNA as they await processing.
The clear and watery substance that bathes the brain and spinal cord is enough to support the growth of neural stem cells in the lab.
Specific traits that distinguish humans from their closest living relatives can be attributed to the loss of chunks of DNA that control when and where genes are turned on.
With the flick of a genetic light switch, researchers have reduced symptoms of anxiety in laboratory mice.
A new genetic method for labeling cells transforms the tangles of neurons within the brain of a fruit fly into fantastic rainbows of color.
Janelia researchers create a new microscope that uses a thin sheet of light to reveal the dynamic inner life of cells.
Triple-negative tumors lack three traits that can be targeted by available breast cancer treatments. But new findings suggest treatment possibilities for these aggressive cancers may be at hand.
Gloria Tavera is a 2011 Gilliam Fellow.
Nine science students from universities across the United States are named the 2011 Gilliam Fellows.
Andria Ashmore is a 2011 Gilliam Fellow.
HHMI has doubled the number of the Gilliam Fellowships available to Ph.D.-seeking students from groups traditionally underrepresented in the sciences.
Chinweike Okegbe is a 2011 Gilliam Fellow.
Benyam Kinde is a 2011 Gilliam Fellow.
Espoir Kyubwa is a 2011 Gilliam Fellow.
Nicolas Altemose is a 2011 Gilliam Fellow.
Nadia Herrera is a 2011 Gilliam Fellow.
Jessica Cabral Jimenez is a 2011 Gilliam Fellow.
Sandra Jones is a 2011 Gilliam Fellow.
The HHMI Bulletin iPad app is now available for download in the Apple App Store.
A newly identified genetic marker appears to predict a diagnosis of post-traumatic stress disorder in women, but not in men.
Graham Walker will talk about running a science education research group and developing resources for MIT and the larger education community in a AAAS plenary talk.
A rapid new method of blocking gene function is letting researchers dissect how stem cell progenitors in the skin split their energy between creating copies of themselves and crafting specialized new cells.
A corrective strategy used by astronomers to sharpen images of celestial bodies can now help scientists see with more depth and clarity into the living brain of a mouse.
Scientists have used next-generation DNA sequencing tools to identify a mutation in a gene that underlies one of the most common forms of severe hypertension.
Neurons that control aggression and mating are closely intertwined deep within the brain.
HHMI is launching a $60 million documentary film initiative that aims to bring high quality, compelling science features to television.
Students at 12 more schools were chosen to participate in a year-long genomics course from HHMI's Science Education Alliance.
The Science Education Alliance is celebrating a major milestone with a scientific publication. The 192-author article is based on the work of students and faculty at the first 12 schools that offered its phage genomics course.
Researchers gain a new view of how genes are converted to protein by freezing the action during the earliest stage of the process.
Thirteen HHMI professors have proposed seven initiatives that they believe would improve the quality of undergraduate science education and student engagement.
Researchers at Stanford University have discovered that they may be able to tweak cancer cells so that they summon their own demise.
In mice with light-sensitive neurons in their brain, illuminating one type of neuron drives the animals to their food bowls, whereas targeting a different type makes them abstain.
Sean Carroll, vice president for science education at the Howard Hughes Medical Institute, will deliver a public lecture titled “Remarkable Creatures: Epic Adventures in the Search for the Origins of Species” at the Janelia Farm Research Campus on February 9.
After a rapid genetic analysis of bacteria collected from Haitian patients, scientists conclude that the strain of cholera currently sweeping through post-earthquake Haiti originated in South Asia.
HHMI has launched an international competition to select up to 35 early career scientists working at academic institutions in 18 countries on five continents.
A study in fruit flies shows that turning back the clock on aging muscles delays aging in the whole animal.
Safe and effective vaccines could complement efforts to treat those already infected with cholera and provide clean water and sanitation to control its spread.
A new study has pinned some of the symptoms of Rett syndrome to a set of neurons that usually work to rein in nerve cell firing in the brain.
New research suggests rising temperatures in the highlands of East Africa are at least partly to blame for the increase in malaria transmission in recent decades.
A previously overlooked group of cells has been shown to be essential in helping adult stem cells multiply and revitalize damaged tissue.
Through an international study of the genome in persons who control HIV without the need for medications, scientists have identified a handful of amino acids that seem to predict a person’s ability to successfully keep the virus in check.
Researchers have shown that radiation-resistance among tumor stem cells can be dramatically lowered by heating them up.
A new analysis of gene duplication across the human genome reveals far more variation in gene copy number than anticipated.
Research in mice suggests that manipulating a single molecule might help eliminate fears that have been etched into memory.
A new study reveals that many pancreatic tumors take nearly 20 years to become lethal after the first genetic perturbations appear, suggesting an opportunity for early diagnosis.
A pair of international research scholars has discovered a deep connection between the circadian clocks of plants and animals.
Dos becarios internacionales de investigación descubren una profunda conexión entre el reloj circadiano de plantas y animales: un gen que está involucrado en la creación de formas alternativas de proteínas relacionadas con el ritmo circadiano.
Susan Lindquist, an HHMI investigator, and Stephen Benkovic, a member of HHMI's Scientific Review Board, are among ten recipients of this year's National Medal of Science.
Cellular clocks throughout the body are precisely synchronized by tiny fluctuations in body temperature.
Roian Egnor and Lou Scheffer will speak at the USA Science and Engineering Festival Expo on the National Mall on October 23.
The KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH) is seeking early career and established research scientists to work for a newly-formed institute in Durban, South Africa, that is dedicated to basic tuberculosis (TB) and HIV research in sub-Saharan Africa.
Laboratory studies of planarians' reproductive cycles suggest new strategies for treating infections that affect hundreds of millions worldwide.
Four HHMI investigators, an HHMI early career scientist, and a senior fellow at Janelia Farm have been elected to the IOM.
Harris will deliver a public lecture titled “Seeing the Brain in Action: A Toolmaker's Perspective” on November 3.
The discovery of an odd couple of genes that team up to trigger rare and difficult-to-detect gastrointestinal stromal tumors could eventually lead to better diagnostics and treatments.
Researchers are inching their way toward a new HIV vaccine strategy by studying the cells of people who have naturally strong immune defenses against the virus.
HHMI and the Gordon and Betty Moore Foundation announce a new partnership to support some of the nation's most innovative plant scientists.
Jeffrey Friedman and Douglas Coleman are being honored for discoveries that led to the identification of leptin, a hormone that regulates appetite and body weight.
Mutations that supercharge a cellular garbage disposal may explain why cancer cells can thrive even as their genetic material multiplies out of control.
A targeted search combined with today's rapid DNA sequencing technology leads researchers to a genetic culprit for a rare disease.
Researchers have new details of how an enzyme helps bacteria slice up foreign genetic material.
Most of the clear cell ovarian carcinoma samples examined in a new study carried a gene mutation that alters the epigenetics of cells.
HHMI researchers have found that malaria parasites can produce multiple versions of a protein that causes infected blood cells to grab onto the inner wall of blood vessels.
Multiple jury prizes were awarded in recognition of contributions advancing technology to automate an important but tedious component of neuroscience research.
If Howard Chang has his way, there will soon be an iPhone app for dialing in RNA structures.
A handful of antibiotic-resistant bacteria can protect an entire colony.
A rare skin disease provides the first example of a disease-causing mutation that spontaneously reverts, producing healthy skin.
With the help of yeast and fruit flies, researchers have identified a distorted gene that appears to be among the most common genetic risk factors for amyotrophic laterial sclerosis (ALS), the devastating neurodegenerative disease also known as Lou Gehrig's disease.
Health officials have held off from recommending an inexpensive malaria drug for widespread use because of concerns about drug resistance. New research drawn from 10 years of field and laboratory studies suggests the drug may be a safe and effective way to prevent malaria.
HHMI researchers develop tiny life-support packets for therapeutic cells.
A cooperative online game has attracted 50,000 players whose “distributed thinking” has, in some cases, proven more powerful than computers in predicting the structure of proteins.
HHMI has awarded $364,000 to more than double the capacity of a vital repository that is a resource for the worldwide community of scientists who study the fruit fly.
A type of prostate cell that has been largely ignored by cancer researchers can trigger malignant prostate cancer.
Janelia Farm researchers show it takes steady hands to measure the brain activity of a fruit fly while it is walking.
HHMI researchers discover that induced pluripotent stem cells retain a genetic memory of their tissue of origin.
A protein that is already the target of experimental drugs that aim to extend life is now known to play a key role in learning and memory.
An ambitious new analysis in mice demonstrates that for more than 1,300 genes active in the brain, there is a significant bias as to which copy is active—the one inherited from the mother or the one that came from the father.
Researchers have identified signaling pathways by which the normal prion protein switches on the general protein synthesis necessary to promote the growth and development of brain cells.
A new imaging method will allow researchers to study speedy cell processes over hours and days rather than seconds, and to examine how morphological defects arise in developing animals.
Five teams will compete in the final round of an international scientific challenge designed to speed development of new computational tools to accurately and automatically reconstruct the shape of brain cells.
Babies delivered via Cesarean section harbor a different ecosystem of bacteria than babies born vaginally.
Jumping genes, thought to have settled down over millions of years of evolution, may be an ongoing source of genetic variation between individuals.
Moore, COO of HHMI's Janelia Farm Research Campus, will assume the new role in September 2010.
Elementary students get a hands-on—and feet-in—experience that teaches them to develop hypotheses and reach conclusions about the relative health of their community stream.
This year, 116 medical, dental, and veterinary students from 47 schools across the country will take a break from memorizing molecular metabolism and studying drug interactions to spend a year in a lab doing hands-on research.
The mucosal immune system is often the first to tangle with microbial invaders. To better understand it, scientists should focus on the interplay between the mucosal immune system and friendly microbes.
HHMI investigator William Newsome and NYU researcher J. Anthony Movshon are recipients of the 2010 Vision Award.
Schmoke, Dean of the Howard University School of Law, succeeds Hanna H. Gray as Chairman of the Trustees of the Howard Hughes Medical Institute.
Researchers have identified a set of hybrid genes that may accelerate the growth of prostate cancer, gastric cancer, and melanoma.
The prestigious $500,000 Lemelson-MIT Prize honors outstanding mid-career inventors dedicated to improving the world through technological invention and innovation.
A pediatric kidney cancer called Wilms tumor may, with just a few genetic changes, hijack pathways that ordinarily drive development of normal kidney tissue.
HHMI researcher Thomas C. Sudhof shares the 2010 Kavli Prize in Neuroscience with Richard H. Scheller and James E. Rothman.
A new genetic analysis suggests that the strains of influenza circulating in the United States can migrate to the rest of the world.
HHMI and the University of KwaZulu-Natal announce appointment of Bishai as the first permanent director of the KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH).
A mysterious swallowing disorder bears similarities to a disease that afflicts parrots and other exotic birds.
A genome-wide search reveals a genetic survival pathway that is switched on in many of the most aggressive glioblastomas.
A unique analysis of environmental contributors to type 2 diabetes has confirmed a link between several pollutants and the disease, while also pointing toward a form of vitamin E as a possible risk factor.
Thirteen HHMI professors with successful science education programs were awarded a total of $9 million over the next four years.