HHMI investigators have found a cellular target of survival signals that can override programmed cell death.
Genetic studies have uncovered a host of new genes involved in the formation of spores in yeast. The studies may illuminate germ cell production in vertebrates.
HHMI researcher Leonard Zon leads a team that has cloned a zebrafish anemia gene, producing one of the first fish models of a human disease. The achievement opens a new avenue for studying the genetics of human diseases.
Grants will help selected institutions to sustain their critical biomedical research activities amid major changes in the U.S. health care system.
HHMI researchers show that ribozymes and enzymes are ready to perform their biological function as soon as they are produced.
HHMI selects young physicians to receive support to train as physician-scientists.
$800,000 HHMI grant will enable JSTOR to offer online access to all past issues of Science, the Proceedings of the National Academy of Sciences and other journals.
The tumor suppressor p16 normally holds the growth-promoting molecule Cdk6 in check. New structural insights may explain how Cdk6 slips free from p16, promoting cancer development.
HHMI researchers produce the first glimpses of the molecular machinery that propels neurotransmitters into the synapse.
New HHMI Web site provides hands-on activities for elementary school students.
Purnell W. Choppin, president of the Howard Hughes Medical Institute, has announced that he will retire at the end of 1999.
More than $425 million awarded since 1988 to revitalize undergraduate biological sciences education.
HHMI investigators have found another molecular landmark that points growing neurons to their proper destination in the brain or spinal cord.
Researchers report the first hard evidence that most cases of colon cancer arise when mutations in a genetic "master brake" help to switch on a well-known cancer-promoting gene.
Researchers used to identify important developmental genes one at a time. Now, a technique developed in Drosophila is taking wing, and hundreds of novel genes have been found.
Researchers find that a drug used to treat adult-onset diabetes may promote the formation of colorectal tumors.
The human immune system can recognize and destroy thousands of invaders. Did this diversity come about accidentally when a mobile piece of DNA inserted itself into the mammalian genome more than 450 million years ago?
Researchers discover new details about how cells monitor the signals that stimulate proliferation or shut down cell growth. Such signals can turn a normal cell into one that grows uncontrollably, the first step in the development of cancer.
A powerful, award-winning video that encourages minority students to pursue careers is now available on the Web.
Meeting Features Leading Biomedical Scientists From Central Europe, Former Soviet Union and the Baltics
Salt is poison for people with high blood pressure. Genetic studies are beginning to clarify who is at risk and why.
Scientists Determine Structure of HIV-1 Protein that Grasps Human Cells.
Researchers have identified a faulty conduit into nerve cells that causes them to fire uncontrollably, triggering the brief seizures that characterize some forms of epilepsy.
eCircadian clocks maintain the sleep-wake cycle for a 24-hour day in a variety of organisms. Two HHMI researchers and their colleagues have discovered more of the clock's molecular components.
Hughes investigators have discovered a family of packemaker ion channels that power the heart and the brain
Knockout mice point the way to a new theory of how a ubiquitous protein may promote heart disease.
The Institute plans to award $12 million in new grants for precollege science programs at biomedical research institutions.
Jeremy R. Knowles, Dean of the Harvard University Faculty of Arts and Sciences, has been elected a Trustee of the Howard Hughes Medical Institute.
HHMI researchers have discovered a genetic mutation that damages heart muscle so that it dilates to the point where the heart can no longer pump blood.
Familial hypertrophic cardiomyopathy is the most common underlying cause of sudden cardiac death in young athletes. New research suggests the disorder may be more widespread than previously thought.
Research to improve vaccines for infectious diseases must move forward. At the same time, according to HHMI investigator Barry Bloom, scientists should be perfecting vaccines that tackle pathogens associated with other diseases, such as cancer and heart disease.
Hughes investigators have discovered that a compound produced by the ocean-dwelling sponge Haliclona shuts down the ubiquitous cellular motor proteins that power cell division and a variety of other processes.
For nearly 50 years, scientists have wondered what a potassium channel looks like. Now, an HHMI research team at The Rockefeller University unveils the channel's surprising architecture.
Spontaneous neural activity in the developing brain is necessary to help organize the detailed connections that exist in the visual system.
Recent research may help clarify whether type 2 diabetes is caused by errant genes or faulty biology.
New Web site provides 'one-stop shopping' for young researchers seeking fellowships, grants.
How does a virus inactivate a tumor suppressor protein? Hughes researchers have crystallized one key tumor suppressor in the act of being handcuffed by a fragment of the human papilloma virus.
Impact of Market Changes on Medical Research and Training to be Considered at Conference at HHMI on February 23-24
The discovery of two nerve cell hormones and their receptors may help explain how the brain senses hunger signals and responds by increasing appetite.
Hughes investigators have identified two of the Ebola virus's main targets in the human body. They are now working on a vaccine against Ebola virus that primes the immune system to ward off the virus.
Three teams of Hughes researchers are closer to understanding how axons, the long projections of nerve cells, grow toward and across an organism's midline to wire up both sides of the body.
HHMI researchers have determined the three-dimensional structure of a protein-RNA complex that shepherds the production of infectious copies of HIV. The structure is a promising target for new antiviral drugs. Article published in the January 16, 1998 issue of Science.
Researchers suspect that a combination of genes and environment determine one's susceptibility to allergic conditions. Hughes researchers and colleagues at Washington University have identified a mutant protein that may cause hypersensitivity to common allergens.
HHMI physician postdoctoral fellow Michael Yaffe and his colleagues have demonstrated a new mechanism that governs chaperone activity and affects the vitality of cells.
HHMI predoctoral fellow develops a computer program that offers a quick, easy and free way to produce restriction maps of DNA sequences.
Benjamin Doranz, an HHMI predoctoral fellow, is helping to devise a gene therapy technique that could destroy the hidden, latent reservoir of HIV-infected cells that escape drug therapy. Article published in the November 21 issue of Science.
HHMI international scholar B. Brett Finlay hopes to learn exactly how E. coli adheres to target cells - and to improve the treatment of diarrheal diseases.
New centers at medical schools provide centralized access to the increasingly powerful tools and specialized expertise that drive modern biology.
HHMI's representative in Russia, Laura Kennedy, has helped the Institute's international research scholars in the region to overcome a wide range of problems.
Research by an undergraduate at the University of South Carolina could lead to a better understanding of the genetic relationship among dinosaurs, birds and alligators.
Hanna H. Gray, president emeritus and Harry Pratt Judson Distinguished Service Professor of History of the University of Chicago, has been elected chairman of the Trustees of the Howard Hughes Medical Institute, effective November 4.
Lisa Goodrich and HHMI investigator Matthew Scott are probing how genes that guide normal development can sometimes go awry and lead to cancer.
Stephen M. Cohen has been elected vice president and chief financial officer of the Howard Hughes Medical Institute by its Trustee, it was announced today by Purnell W. Choppin, M.D., president of the Institute.
More and more institutions are sending undergraduates off campus - to industry, a government laboratory, another college or university - to do research.
Two Hughes investigators, working in parallel, advance our understanding of AIDS by discovering the way HIV, the virus that causes AIDS, penetrates a cell.
Hughes researcher Yuet Wai Kan and his colleagues have designed a prenatal blood test to diagnose fetuses at risk for developing sickle cell anemia and thalassemias.
Doug Wright has left behind the construction business to study stem cells and search for new techniques to improve the success of bone marrow transplants.
Hyock Joo Kwon has helped to determine the structure of the active site of bacteriophage lambda integrase, a well-studied protein that had proven difficult to visualize.
The Howard Hughes Medical Institute today announced that is has awarded $15 million in grants to support the research of 47 outstanding biomedical researchers in Argentina, Brazil, Canada, Chile, Mexico and Venezuela.
A talk by Argentine scientist Ana Belen Elgoyhen highlights the problems faced by many biomedical researchers in Latin America.
The College of the Holy Cross offers free training every summer to two fortunate Worcester Public School science teachers.
High school science teachers are refreshing their skills at summer programs offered by the College of the Holy Cross, the University of Missouri-Columbia, and the Woodrow Wilson National Fellowship Foundation.
The University of Missouri-Columbia is bringing state-of-the-art equipment to teachers who might not otherwise have such exposure.
While filling in for public school teachers who are away on sabbatical, some recent science graduates from the College of the Holy Cross discover that teaching is their calling.
Teacher training programs give scientists new understanding and respect for their precollege colleagues.
Stephen Blacklow, a former HHMI postdoctoral fellow, has made a discovery that may explain why some people have high cholesterol levels
Jeffrey M. Friedman and colleagues report that the weight-reducing effects of the hormone leptin result from interaction with a receptor in the brain's hypothalamus and other tissues.
New Jersey State Aquarium runs a day camp and other programs where Camden youngsters can explore science.
Participants at HHMI's undergraduate science education conference discuss techniques for determining the impact of their efforts.
Education conference at HHMI focuses on th eimpact of new technology on science education in the schools and other settings.
Garnett L. Keith, chairman of SeaBridge Investment Advisors L.L.C., in Summit, New Jersey, has been elected Trustee of the Howard Hughes Medical Institute, the nation's largest philanthropy.
Graeme Bell and other researchers have found a gene that may make people susceptible to type II diabetes.
Two HHMI physician postdoctoral fellows have developed Medsite Navigator to assist patients, physicians and researchers in locating high-quality medical and scientific information.
Scattered across reservations on the wind-swept plains of North Dakota, a network of schools is encouraging Native American students to pursue science.
The Institute brings together its international research scholars from 10 European countries, in the Czech capital.
A team of HHMI scientists has peered deep inside HIV-1 for a closer view of the fragile shell that envelops the virus' genetic material.
HHMI's international program brings together scientists from the Baltics, Central Europe and the former Soviet Union.
Dan Littman and fellow researchers have found a receptor for HIV that appears to play a key role in the transmission of the virus between individuals.
Michael Naski has helped to identify a genetic mutation that can cause bones to stop growing, leading to a form of dwarfism.
HHMI researchers have learned that basal cell carcinoma is caused by a defect in a gene that restrains cell growth.