A new technique transforms biological tissue into an optically transparent sample that retains its original structure and molecular information.
Stephen Elledge recognized for research on DNA repair.
New research reveals how a localized source of a signaling molecule directs a dividing stem cell to produce two different cells—one identical to its parent, the other a more specialized cell type—and aligns those cells.
At a briefing at the White House, HHMI announces $22.5 million, five-year grant to help major research universities train a new generation of science and mathematics teachers.
Up to 15 new HHMI professors will receive $1 million over five years to create activities that integrate their research with student learning to enhance undergraduates' understanding of science.
The Howard Hughes Medical Institute selects nine highly talented college students to receive the 2013 Gilliam Fellowships for Advanced Study.
Researchers have found that temperatures on the surface of the tropical South Atlantic Ocean in July can predict the severity of malaria outbreaks in northwestern India that begin to peak four months later.
Scientists have a new view of the cellular machinery that assembles directly on DNA and readies it for transcription into RNA, the first step in protein production.
Misha Ahrens, Shaul Druckmann, Krystyna Keleman, and Minoru Koyama will each lead a small research team working toward learning how the brain’s neural circuits process information and guide behavior.
Stem cells inside the parasite that causes schistosomiasis can regenerate worn-down organs, which may help explain how the parasites can live for years inside their host.
Células madres en el interior del parásito que causa la esquistosomiasis pueden regenerar los órganos desgastados, lo que podría ayudar a explicar cómo pueden vivir por años o incluso décadas dentro de su huésped.
Three HHMI scientists are among 11 honored for excellence in research aimed at curing intractable diseases and extending human life.
Jennifer Tour Chayes, Managing Director of Microsoft Research New England and Microsoft Research New York City, will speak about "Age of Networks" on February 20 at 7 PM.
EarthViewer, a free, interactive app designed for the iPad, lets users explore the Earth's history with the touch of a finger by scrolling through 4.5 billion years of geological evolution.
Científicos han descubierto que arreglos periódicos de actina en forma de anillos rodean las largas fibras axonales de las células nerviosas, en contraste con las redes lineares que comúnmente le dan forma a las células.
Scientists have discovered that periodic ring-shaped actin arrangements encircle the long axonal fibers of nerve cells, in contrast to the linear meshworks that typically give cells their shapes.
HHMI scientists discover how a single molecule in a living cell can respond differently to different strengths of an external signal.
New lab heads Barry Dickson and Nikolaus Grigorieff will move to Janelia in 2013.
A new analysis suggests that the regulatory protein MeCP2 works with the modified nucleotide 5hmC to facilitate gene activation in the brain.
Scientists have discovered the molecular pathway responsible for detecting loose bits of DNA outside a cell’s nucleus and setting off an immune reaction.
Rather than scrutinizing hours of video, scientists can quickly teach the software how to recognize key behaviors.
AAAS recognizes Ulrike Heberlein and Nelson Spruston for meritorious efforts to advance science.
O'Shea, HHMI investigator and professor at Harvard University, will lead HHMI's science programs.
New film and media production company aims to be a significant contributor to the science documentary arena.
Betzig will discuss historical connections between astronomy and microscopy on Dec. 12.
A new DNA sequencing technique has enabled researchers to map for the first time the influential chemical modifications known as methylation marks throughout the genome of a pathogenic bacterium.
Susan Desmond-Hellmann, M.D., M.P.H., chancellor of the University of California, San Francisco, becomes one of 11 Trustees of the Institute.
Hanna H. Gray, Ph.D., former chair of the HHMI Trustees, retires after serving the Institute since 1984.
Sean Carroll introduces "The Day the Mesozoic Died" at national teachers conference.
Seven HHMI investigators and two members of HHMI’s Scientific Review Board have been elected to the Institute of Medicine of the National Academies.
eLife makes first collection of research articles available online.
Robert Lefkowitz de HHMI comparte el premio con Brian Kobilka por estudios sobre los receptores acoplados a proteínas G.
Only a few animals, such as songbirds, whales, and dolphins, are known to be vocal learners, modifying the sequence or pitch of their sounds based on what they hear from other members of their species. New evidence suggests mice can be added to that list.
HHMI's Robert Lefkowitz shares prize with Brian Kobilka for research on G-protein coupled receptors.
HHMI and the University of KwaZulu-Natal open new research institute in Durban, South Africa.
In experiments with rats, researchers found that the rejection of an old belief correlates with abrupt changes in activity in a region of the brain involved in cognitive functions such as reward anticipation and decision-making.
HHMI selects 13 of the world’s leading basic science researchers to receive Senior International Research Scholar (SIRS) awards. The awards support outstanding biomedical scientists working outside the United States who have made significant contributions to fundamental research in the biological sciences.
HHMI awards three two-year grants to aid in developing the next generation of interdisciplinary scientists, in collaboration with the National Institute of Biomedical Imaging and Bioengineering.
HHMI investigator Ronald D. Vale of UCSF will share the 2012 Albert Lasker Basic Medical Research Award.
Together, the teams include 28 researchers from 20 institutions in the United States, Germany, and Israel.
Thousands of genes in organs throughout the body show predictable daily fluctuations. New research reveals complexity in how those genes' cycles of activity are controlled.
A discovery of how ethylene triggers changes in gene activity could lead to new ways to stop or slow ripening.
Nine students, listed below with their undergraduate institutions, were selected as Gilliam fellows in 2012.
The vaccinia virus increases the size of its genome when it confronts the immune system, thereby increasing the odds of a random mutation that will improve its survival.
By investigating the cause of a fatal snake disease, scientists have found a virus that links two known virus families that can cause fatal hemorrhagic fevers in humans.
Mutations in four different DNA damage repair genes have been linked to chronic kidney disease.
Scientists have catalogued and compared the hundreds of types of bacteria that associate with the roots of the model plant Arabidopsis under various conditions.
HHMI has awarded more than $2 million in fellowships to 50 promising graduate students from 19 countries.
Meet the 2012 International Student Research Fellows
Nurse's lecture on Great Ideas of Biology will take place at HHMIs Janelia Farm Research Campus on July 31.
With a newly discovered component of an adaptive bacterial immune system, scientists have identified a targeted method of slicing DNA that they say can be easily customized for a variety of applications.
Short strands of piwi-interacting RNA may detect foreign invaders by determining whether a gene has ever been turned on in an organism's past.
Quake is being recognized for his work in drug discovery, genome analysis and personalized medicine.
A new imaging technology developed at Janelia lets users track each cell in an embryo as it takes shape over hours or days.
Thirty years after their discovery, scientists have the first picture of a Wnt protein, a member of a protein family that includes some of the most important regulators of growth and development.
HHMI scientists have determined the three-dimensional structure of two proteins that help keep the bodys clocks in sync.
The three scientists are recognized for elucidating basic neuronal mechanisms underlying perception and decision.
Arthur Horwich and Franz-Ulrich Hartl honored for contributions to the understanding of the molecular mechanism of protein folding.
Using genetic programming, researchers have identified a specific type of cell in the outer layers of the brain that is crucial for Prozac's action.
A list of the 47 small colleges and universities awarded a four-year grant in HHMI's science education initiative.
Colleges receive funds to incubate new science education courses and programs.
Seventy students from 27 medical schools across the country will participate in HHMI's year-long Medical Research Fellows Program.
Researchers lay out evidence for how an unusually efficient enzyme evolved from non-catalytic ancestor proteins.
In the region of the brain that controls motor planning, a self-reinforcing loop of neuronal signaling helps establish connectivity during early development.
Researchers have uncovered the enzyme that transfers phosphate to milk proteins like casein, but also to proteins found in bones and teeth enamel.
Dixon, who has led HHMI's scientific programs since 2007, will retire from the Institute in summer 2013.
Fourteen HHMI scientists are among 84 newly elected members.
Bonnie Bassler and Jack Dixon are among eight newly elected foreign members.
Nine HHMI investigators and one HHMI Professor are elected to the American Academy of Arts and Sciences.
The May 9th lecture, Shining Light on How the Brain Works, is free, but tickets are required for admission.
Many of the most severe mutations identified in patients with autism affected proteins that work together in one large interconnected network.
As fish in different parts of the world adapted to live in fresh water, the same sites in the genome were changed time and again.
HHMI researchers Thomas M. Jessell and Michael Rosbash honored for significant contributions to medical science.
HHMI seeks to appoint up to 30 new HHMI investigators in 2013. Applications open on March 15, 2012.
Long, ropy fibers were long thought to be the causes of these diseases including Alzheimer's and Parkinsons, but research over the past decade has revealed that fibers arent amyloid proteins' most toxic form.
In a mouse model of Alzheimer’s disease, an overactive enzyme causes memory problems by shutting off genes related to neuronal communication.
The Gilliam program aims to increase the diversity of college and university faculty by supporting future scientific leaders during their graduate studies.
Defectos en el gen que codifica para la proteína más grande del cuerpo humano son responsables de más casos de la enfermedad que los causados por todas las otras mutaciones conocidas.
Defects in the gene that encodes the human body’s largest protein are responsible for more cases of dilated cardiomyopathy than are caused by all other known mutations associated with the heart disorder.
HHMI researcher and colleagues design and develop drug that prolongs survival in men with advanced prostate cancer.
Investigador del HHMI y sus colegas diseñan y desarrollan una droga que prolonga la supervivencia de hombres con cáncer de próstata avanzado.
HHMI investigator Brian Druker honored for role in developing new cancer drug.
Meet the 2012 International Early Career Scientists
Top biomedical scientists from 12 countries will receive an important boost at a critical time in their careers from HHMI’s inaugural International Early Career Scientist awards.
Perlmutter's lecture on “Building Better Medicines: Drug Discovery in the 21st Century” will take place on February 15.
A breakdown of cellular junk may explain how exercise fends off metabolic disorders and protects against other diseases.
Researchers have discovered a molecular master switch that triggers the genetic overhaul plants need to fight off pathogens.
The gene mutation that causes retinoblastoma changes the way cells turn on and off many other genes.
Researchers have discovered how plants regulate the development of the pores through which critical exchanges of water and carbon dioxide occur.
By resurrecting the ancient forms of a molecular machine, scientists have learned how simple evolutionary processes can produce the complex assemblies of molecules that allow modern cells to function.
New research shows that fluoride has dramatic effects on bacteria inside the mouth.
Sean B. Carroll, HHMI’s vice president for science education and a long-time HHMI investigator, has been awarded the 2012 Benjamin Franklin Medal in Life Science.
Scientists have pinpointed the gene responsible for a disease that causes seizures in infancy and sudden, uncontrollable movements in adolescence and early adulthood.
Studies of fragile X syndrome and tuberous sclerosis show that for brain cells to function normally, neural synapses must produce just the right amount of protein.
By activating regions of the brain linked to food-related pleasure, scientists are learning how the brain mediates the link between food preferences and hunger.
A group of internationally recognized scientists was named to the editorial team of eLife, the new open-access journal to be launched by HHMI, Wellcome Trust and Max Planck Society.
Blood vessels in the lungs produce signals that activate the regeneration of alveoli—the tiny cavities through which blood takes in oxygen and releases carbon dioxide.
The fruit-fly protein Zelda helps govern the developmental handoff from mother's influence to an animal's own genome.
Fruit flies integrate smell and visual information to fine-tune flying behavior.