Experimental work has led to the first mathematical model of a regulatory circuit that blood-forming stem cells use to decide what kind of white blood cell they will become.
Research teams have collaborated to identify the cells and receptor responsible for processing sour taste in mammals.
Children with Loeys-Dietz syndrome should be considered early candidates for surgery to prevent lethal rupture of the aorta.
Scientists working at the epicenter of the South African AIDS epidemic have discovered how HIV "exhausts" killer T cells that would otherwise attack the virus.
Científicos que trabajaban en el epicentro de la epidemia del SIDA en Sudáfrica han descubierto cómo el VIH “agota” a las células T asesinas, que de otra manera atacarían al virus.
HHMI scientists discover a human DNA sequence that has evolved rapidly since humans diverged from their closest evolutionary relatives.
Proteins can wreak havoc in the brain even when the genes that encode them are perfectly normal.
New technique images cellular proteins with near-molecular resolution.
A detailed view of a smallpox enzyme opens the way to developing the first drugs against virus.
Using real-time imaging to track malaria infection in live mice, researchers have discovered one of malaria's sneakiest tricks.
Usando procesamiento de imágenes en tiempo real para detectar infecciones palúdicas en ratones vivos, unos investigadores han descubierto uno de los trucos más ocultos del parásito de la malaria.
Scientists have identified a key enzyme that the dengue virus uses to replicate, triggering the potentially fatal dengue hemorrhagic fever.
Científicos identifican una enzima clave que el virus del dengue utiliza para replicarse, lo que activa la potencialmente fatal fiebre hemorrágica del dengue.
A new drug target could defeat HIV's rapid evolution, its main mechanism of drug resistance.
Nuevo blanco de ataque de drogas podría derrotar la rápida evolución del VIH, su mecanismo principal de resistencia a drogas.
Researchers have discovered a critical function for a protein involved in spinal muscular atrophy (SMA), the number one genetic killer of children under the age of two.
New research indicates that drugs that target a cell growth pathway called the JAK-STAT pathway are likely to be effective against certain chronic leukemias.
Researchers analyze proteins to find cancer-causing mutations.
A natural chemical may yield a prime target for novel cholesterol-lowering drugs and the blueprint for a new generation of antibiotics.
A single genetic mutation contributes to a lifesaving color variation in Florida beach mice.
Researchers have identified a protein that could aid development of methods to grow skin to treat patients.
Researchers have greatly shortened the time it takes to create a mouse model of human liver cancer, and used the technology to identify two genes that drive the disease.
HHMI researchers discover that brittle prion particles break into new "seeds," which spread infection quickly.
Defects in a critical cellular pathway can lead to symptoms of Parkinson's disease.
Neurons in the brains of mice sprout robust new connections when the animals adjust to new experiences.
Researchers obtain the first definitive look at how a protein often implicated in cancer development turns itself on to promote cell growth.
An experimental drug reverses the signs and symptoms of patients whose chronic myeloid leukemia has failed to respond to Gleevec.
Certain variants of a simple sugar ameliorate Alzheimer's disease in mice.
A handful of Pittsburgh high school and college students who isolated and characterized 30 new viruses that infect bacteria have co-authored a research article in a peer-reviewed scientific journal.
With help from some drowsy fruit flies, HHMI researchers identify a region of the brain that controls sleep.
HHMI researchers at Stanford have found that they can increase bone mass in mice by tweaking the shape of a regulatory protein.
Researchers discover a clue to how bacteria can spread through an insect population.
A new resource will speed understanding of inherited disorders that kill cells in the brain.
HHMI researchers show that reducing production of sterols can prevent the rapid growth of medulloblastoma cells in culture.
New technique allows scientists to measure the abundance of thousands of proteins with unprecedented resolution.
A new panel of compounds may be a powerful tool to evaluate cellular enzymes as potential targets for drug design.
HHMI researchers pioneer a new approach to determining the structure of protein complexes.
Scientists have mapped a critical hormone signaling pathway that regulates the stature of plants.
The repeated copying of a small segment of DNA in the genome of a primeval fish may have been crucial to the transition of ancient animals from sea to land.
Científicos mapean una vía de señalización hormonal que regula la estatura de las plantas.
Researchers have a new understanding of how sperm and eggs begin life with exactly one copy of each chromosome.
Patients with multiple sclerosis carry a population of immune cells that over-react to Epstein-Barr virus.
Researchers have identified a protein that reins in the rogue activity of the molecules that make the amyloid-beta protein, which may prevent normal brain function in people with Alzheimer's disease.
Five current HHMI investigators, one trustee of the Institute, one member of the Institute's scientific review board, and one HHMI international research scholar were among those honored.
Seven HHMI investigators, along with an HHMI professor, an international research scholar, and a member of the scientific review board are elected to the academy.
Researchers have created a mouse model that closely mimics the most common childhood brain tumor.
HHMI research shows that evolution is an incessant tinkerer when it comes to complex traits.
Researchers have discovered the first African hantavirus, a type of rodent-borne virus that can cause life-threatening infections in humans.
A change in a single gene may be in large part responsible for the evolution of flight in bats.
Researchers find new clues to why some kinds of leukemia are more aggressive and deadly than others.
A common blood pressure medication may help prevent potentially deadly complications of Marfan syndrome.
Cells use specialized segments of RNA to ensure that there is an adequate supply of magnesium.
Una medicación comúnmente prescrita para la presión sanguínea puede proporcionar el primer atisbo de esperanza para la prevención de las complicaciones potencialmente mortales del síndrome de Marfan, una enfermedad genética que debilita la intrincada estructura de vasos sanguíneos.
Researchers have identified a gene mutation that weakens small blood vessels, increasing the danger of stroke.
Joan A. Steitz and Ronald M. Evans have received the Gairdner International Award.
New research indicates there is a useful difference between cells that keep the blood system healthy and the stem cells that make leukemia lethal.
Scientists have traced female fruitflies' complex behavioral change after mating to a single protein in the semen of males.
HHMI researchers have discovered a new retrovirus in humans that is closely related to a cancer-causing virus found in mice.
Enzymes that can harm the brain immediately after a stroke may actually be beneficial days later.
Sustained over the long term, a decrease in low density lipoprotein (LDL) cholesterol of as little as 15 percent can dramatically reduce the risk of coronary heart disease.
Researchers have mathematically confirmed that humpback whales have their own syntax that combines sounds into phrases to form songs that last for hours.
HHMI researchers have demonstrated that they can nearly eliminate production of infectious prion proteins in livestock by using an innovative approach based on RNA interference (RNAi).
A new color-changing tag based on the light produced by a variety of sea coral could help scientists follow individual proteins inside living cells.
An HHMI research team has identified the cellular receptor for botulinum neurotoxin A.
Equipo de investigadores del HHMI identifica el receptor celular de la toxina botulínica A.
A rare opportunity to study patients with an intractable form of epilepsy leads to the discovery of specific neurons in the human brain that respond to novel or familiar objects.
Researchers studying strains of a lethal canine virus and a related human virus have determined why the canine virus was able to spread so quickly from cats to dogs and then from sick dogs to healthy dogs.
Researchers in Argentina have determined that night blindness is a new clinical symptom of Chagas disease.
Using computer-simulated HIV protease molecules, scientists have identified a potential new drug target for drug-resistant HIV infection.
Investigadores de Argentina han determinado que la ceguera nocturna es un nuevo síntoma clínico de la enfermedad de Chagas.
Using laundry whitener and dirt-dwelling bacteria, researchers may have found a major clue to the mystery of how living organisms manufacture the essential vitamin B12.
The virus that has a causative role in Kaposi's sarcoma hitchhikes inside cells to ensure its survival.
A new study by HHMI researchers shows that macrophages may also permit prostate cancer to flourish.
Researchers have gained insight into how a wriggling sperm thrusts itself into an egg.
An innovative method of categorizing myosin, one of three molecular motors that produce movements within cells of the body, had dramatically increased the amount of information available about these essential proteins.
Scientists have determined the structure of an essential piece of the telomerase enzyme.
Científicos determinan la estructura detallada de una pieza esencial de la enzima telomerasa, importante contribuidora de la gran mayoría de los cánceres humanos. La comprensión de la forma física de la proteína ha llevado a un mejor entendimiento de la forma en la que inmortaliza las células –y debería ayudar a los científicos a diseñar drogas contra el cáncer que sean ampliamente eficaces–.
Neuroscientists at Harvard Medical School have found a molecule that the brain uses to slam the brakes on daily activity at certain times.
Scientists in India led by an HHMI international research scholar have identified five key genes that enable the bacteria that cause TB to acquire the iron they need to promote infection.
Científicos de la India, conducidos por un becario internacional de investigación del HHMI, identifican cinco genes claves que permiten que la bacteria que causa la tuberculosis adquiera el hierro que necesita para mantener el crecimiento y promover la infección.
Knocking out a gene that helps repair nicks in DNA causes young mice to develop many of the degenerative characteristics of their wizened elders.
HHMI scientists and colleagues at Johns Hopkins have found a critical clue that helps explain what goes wrong in a key region of the brain at the onset of Down syndrome.
An HHMI international scholar at the Pasteur Institute in Paris has found the malaria parasite developing in an unexpected place: the lymph nodes.
Becario internacional de investigación del HHMI en el Instituto Pasteur de París encuentra que los parásitos de la malaria se desarrollan en un lugar inesperado: los nódulos linfáticos.
HHMI researchers have discovered how a new generation of drugs thwarts a deadly mutation that causes chronic myelogenous leukemia.
Investigadores del HHMI han descubierto la forma en la que una nueva generación de drogas impide que una mutación mortal cause leucemia mielógena crónica.
HHMI scientists peel back some of the mystery about how cells are able to turn off genes selectively.
Científicos del HHMI desentrañan parte del misterio de la forma en la que las células pueden desactivar genes selectivamente.
Investigadores descubren el trabajo de una de las proteínas de respuesta al daño en el ADN más común, enzima que ha intrigado a los científicos desde que fue descubierta.
Researchers have identified the job of one of the most common DNA-damage response proteins, an enzyme that has puzzled scientists ever since it was discovered.
HHMI researchers have discovered a molecular link between a high-fat, Western-style diet, and the onset of type 2 diabetes.
Investigadores del HHMI han descubierto una relación molecular entre una dieta alta en grasas, dieta de estilo occidental, y el inicio de la diabetes tipo 2.
HHMI international research scholars have determined how the malaria parasite can turn on one cloaking gene and silence dozens of others until they are needed.