Una mutación en un único gen puede hacer que muchos otros genes comiencen a funcionar—o dejen de hacerlo—, y puede ser que estos cambios causen en última instancia síntomas clínicos. La identificación del conjunto completo de genes afectados parecía imposible. Pero ese ya no es el caso.
An HHMI professor has teamed up with the Posse Foundation to develop a bold plan to equip inner-city high school students to succeed in the sciences.
HHMI scientists have discovered that microRNAs can also shut down the proliferation of cancer cells.
Científicos descubren que fascinantes trocitos de material genético conocidos como microARNs también pueden detener la proliferación de células cancerígenas.
Researchers have identified a master hormone that allows the body to fuel itself with stored fat during times of fasting.
Researchers have measured the electrical activity at play in brain cells as animals make a choice based on their interpretation of a set of visual cues.
Investigadores han medido la actividad eléctrica de células cerebrales cuando los animales realizan una elección basándose en la interpretación de un conjunto de señales visuales.
Researchers have identified a new population of stem cells that act to repair muscle after damage.
Studies in mice show that lithium can ease the symptoms of spinocerebellar ataxia type 1, an inherited neurodegenerative disorder.
A new database created by HHMI researchers reveals a 700-member strong army of proteins involved in the DNA repair response.
Researchers have found that neural activities in the brain gradually change, even when nothing new is being learned.
A new kind of test tube is revolutionizing the way researchers observe the behavior of single molecules of DNA, RNA, or proteins.
New evidence shows that Wilms tumor—a rare kidney cancer that affects children—promotes its own growth agenda by taking over a genetic program used by normal cells during development.
A major new research effort is now beginning to uncover the structural variations in DNA that contribute to genetic differences between humans.
Researchers have identified small regions within a yeast protein that control the protein's conversion to an infectious agent known as a prion.
Un nuevo e importante trabajo está comenzando a descubrir diferencias estructurales en el ADN que generan diferencias genéticas entre los humanos.
Researchers have found that a much-studied gene provides branches of nerve cells the ability to recognize one another and grow apart, helping them cover as much space as they can evenly and efficiently.
Mice whose brains had lost a large number of neurons regained long-term memories and the ability to learn after their surroundings were enriched with toys and other sensory stimuli.
Ratones cuyos cerebros habían perdido una gran cantidad de neuronas debido a una neurodegeneración recuperaron las memorias a largo plazo y la capacidad de aprender luego de que sus ambientes fueron enriquecidos con juguetes y otros estímulos sensoriales.
Once thought to play an essential role in helping to package neurotransmitters for release, dynamin 1 may not be needed for basic nerve cell function.
A newly identified gene mutation in mice has revealed how the molecular oscillations behind circadian rhythms are kept on track.
Chitin is the stuff of crab shells and the carapaces of dust mites. It may also be the stuff that sets off asthma.
La quitina es la materia de los caparazones de los cangrejos y de las cubiertas de los ácaros del polvo, de las membranas celulares de los líquenes y de incluso las partes internas rígidas de gusanos parasitarios. También podría ser la materia que inicia el asma.
New research has found that genes that enhance the virulence of bacteria are clearly favored for evolutionary survival.
Nueva investigación ha encontrado que genes que aumentan la virulencia de bacterias son favorecidos claramente por la supervivencia evolutiva.
Researchers have devised a way to activate neurons in a living mouse by shining light on the surface of the animal's brain.
Genetically installing light-sensitive proteins in the brains of mice enables researchers to map functional brain wiring over long distances at unprecendeted levels of detail.
Eligible Institutions for the 2008 Investigator Competition.
HHMI will hold a national competition for investigators and plans to name as many as 50 new researchers by spring 2008.
El HHMI llevará a cabo una competición nacional para investigadores y planea nombrar a tanto como 50 nuevos investigadores en la primavera de 2008.
Studies of human tumor cells implanted in mice have shown that the abnormal activation of four genes drives the spread of breast cancer to the lungs.
Estudios de células tumorales humanas que fueron implantadas en ratones han demostrado que la activación anormal de cuatro genes hace que el cáncer de mama se disemine a los pulmones.
Researchers have established how the structure of receptors on the surface of T cells enables them to recognize both self and foreign cells.
New research has revealed what keeps animals' internal clocks running on time through the long nights of winter and the long days of summer.
Although mice typically view the world with a limited color palette—similar to what some people with red-green color blindness see—scientists have transformed their vision by introducing a single human gene.
Aunque los ratones típicamente ven el mundo con una gama de colores limitada—similar a lo que ven algunas personas con acromatopsia al rojo y verde—unos científicos han transformado su visión al introducir un único gen humano.
Identifying the presence of multiple lineages of HIV can greatly improve the accuracy of genetic analyses designed to pinpoint regions of the viral genome that are important for recognition by T cells.
La identificación de la presencia de linajes múltiples del VIH puede mejorar mucho la precisión de los análisis genéticos diseñados para identificar regiones del genoma viral que son importantes para el reconocimiento por parte de las células T.
The parasite responsible for African sleeping sickness has a fatal response to stress.
Researchers report that the first detailed images of an elusive drug target on the outer wall of bacteria may aid design of novel antibiotics.
Investigadores publican las primeras imágenes detalladas de un blanco de drogas evasivo en la pared externa de bacterias que podría ayudar en el diseño de antibióticos nuevos.
Settling a century-old debate, HHMI researchers have shown for the first time how plants decide to grow.
Terminando con un antiguo debate, investigadores del HHMI han demostrado claramente y por primera vez cómo las plantas deciden crecer.
HHMI researchers identify a genetic mutation that causes early onset coronary artery disease.
Investigadores del HHMI identifican una mutación genética que causa enfermedad arterial coronaria de inicio temprano.
Researchers have developed a fruitfly model that replicates the genetic instability seen in a variety of neurodegenerative diseases.
Scientists have recorded the action involved in assembling telomerase, an enzyme used by cells to protect their genes during the potentially dangerous process of DNA replication.
Sometimes it helps to have a "cheat sheet" when you are working on a problem as difficult as deciphering the relationships among hundreds of thousands of genes.
HHMI researchers map the fine details of the many chromosomal breaks and rearrangements that have reshaped the white-cheeked gibbon's genome.
Adult stem cells call the shots when it comes to their daughters' destinies.
New data suggest that 40-50 percent of human and mouse genes have alternative promoters.
Nuevos datos sugieren que entre el 40 y 50 por ciento de los genes humanos y de ratón tienen promotores alternativos.
Researchers have constructed a protein out of amino acids not found in natural proteins, forming a complex, stable structure that closely resembles a natural protein.
Healthy and viable mice that survive until adulthood have, for the first time, been cloned from adult stem cells.
Por primera, vez ratones sanos y viables que alcanzan la adultez han sido clonados a partir de células troncales adultas.
Precise protein targeting allows cells to build cell-to -cell junctions in the right place.
Changes in an enzyme known to be vital to the body's energy levels may lead to a decreasing ability to stave off diabetes as we get older.
A protein that captures light in ocean-dwelling bacteria puts light's energy to work inside cells.
A drug that keeps blood pressure under control may offer new hope for patients with muscular dystrophy.
HHMI researchers have now found one clue that may tell them why the liver is a master of regeneration.
Investigadores del HHMI han encontrado una pista que podría decirles por qué el hígado es un experto en regeneración.
Researchers have identified a family of proteins that contributes to the survival and regenerative potential of blood-forming stem cells.
Investigadores descubren una familia de proteínas que contribuye a la supervivencia y al potencial regenerador de las células troncales de formación de sangre.
HHMI researchers have reactivated the p53 gene in mice, causing blood, bone and liver tumors to self destruct.
A team led by an HHMI international research scholar has identified a new genetic risk factor associated with the most common form of Alzheimer's disease.
Researchers learn how a set of enzymes contorts itself during the molecular relay race involved in tagging proteins.
Genetically altered mice are helping scientists illuminate the fundamentals of biological clocks.
Researchers have designed a laboratory about the size of a quarter that is capable of conducting thousands of experiments simultaneously.
HHMI scientists are making 'chemical factories' that help laboratory animals produce resveratrol -- the compound behind red wine's frequently touted health benefits.
Scientists can turn on or block regeneration in zebrafish with the flip of a molecular switch.
Researchers have learned how the immune system slices and dices genes so B cells can program antibodies to seek out and destroy invaders.
Two HHMI research teams have discovered new information about how the botulinum neurotoxin shuts down neurons with deadly efficiency.
HHMI researchers discover a line of communication that helps hair follicles organize and align themselves into a well ordered pattern.
Scientists discover a new place to search for the factors that cause neurons to sprout connections.
After five years, some 95 percent of study participants have survived the cancer due to treatment with Gleevec.
P[acman], a new tool for inserting large genes into precise locations on the chromosome, may enable researchers to overcome challenges in pinning down the function of genes.
New research shows that at least 10 percent of genes in the human population can vary in the number of copies of DNA sequences they contain—a finding that alters current thinking that the DNA of any two humans is 99.9 percent identical in content and identity.
Nuevo estudio muestra que al menos el 10 por ciento de los genes de la población humana puede tener un número distinto de copias de secuencias de ADN –descubrimiento que modifica la idea actual de que el ADN de dos seres humanos cualesquiera es un 99.9 por ciento similar en contenido e identidad–.
New findings hint that dendritic spines could make the human brain a far more efficient learning machine than that of other animals.
Analyzing the machinery a roundworm uses to repress genes on an entire chromosome reveals surprising principles about gene regulation.
Here is a list of research institutions that qualify for the 2007 competition.
Brief summaries of the research carried out by the 12 patient-oriented researchers selected by HHMI in 2002
HHMI announces new national competition to appoint outstanding physician-scientists as HHMI investigators. The Institute expects to select approximately 15 new researchers by Fall 2007 and is committing approximately $200 million to their first term of appointment.
Researchers have created a map of the protein landscape that regulates a stem cell's ability to differentiate into multiple types of mature cells.
HHMI researchers and their colleagues developed a systematic method for speeding up the crystallization of proteins, an advance that may greatly aid x-ray crystallography.
A new study suggests that human evolution was not just a matter of spontaneous advantageous mutations arising within the human lineage.
HHMI researchers have created a map that helps explain how the brain generates the assortment of specialized proteins it needs to process information.
A newly identified gene mutation helps explain a subset of cases of osteogenesis imperfecta.
By turning on a single gene, researchers can prevent skin stem cells from maturing into the three types of adult skin cells.
Now that clinical trials have shown ranibizumab's "miraculous" effects on patients' eyesight, a crucial next step is to compare ranibizumab to a related drug, which is less than ten times the cost.
HHMI investigator Craig Mello of the University of Massachusetts Medical School and Stanford researcher Andrew Fire honored for discovery of RNA interference.
El investigador del HHMI Craig C. Mello, de la Facultad de Medicina de la Universidad de Massachussets, y el investigador de Stanford, Andrew Fire, fueron honrados por el descubrimiento de la interferencia de ARN.
A structural protein can determine whether an insect develops the highly organized, light-harvesting eye of a fly.
Some infectious diseases might run in families because susceptibility to them is inherited.
An HHMI international research scholar in Israel has discovered one reason why so-called "flesh-eating" bacteria are so hard to stop.
Algunas enfermedades infecciosas podrían presentarse en ciertas familias porque se hereda la susceptibilidad a las mismas.
Un becario internacional de investigación del HHMI en Israel ha descubierto una razón por la que es tan difícil detener a una bacteria llamada “comedora de carne”.
Howard Hughes Medical Institute investigator Jack W. Szostak at Massachusetts General Hospital, Carol W. Greider of Johns Hopkins University and Elizabeth H. Blackburn of the University of California, San Francisco, have been awarded the 2006 Albert Lasker Award for Basic Medical Research.
HHMI researchers have found that a typical breast or colorectal tumor results from mutations in about 90 genes.
A single molecular switch plays a central role in inducing stem cells in the brain, pancreas, and blood to lose function as they age.