Susan Lindquist believes that if “personalized medicine” for complex neurodegenerative disorders is to become a reality then scientists must begin developing more rigorous approaches to identifying and validating promising new therapies.
Images in biology textbooks may give the misleading impression that the cell membrane is a passive envelope that does little more than keep the cell’s internal contents in place. Howard Hughes Medical Institute researcher Douglas C. Rees prefers to think of the outer membrane of human cells as a dynamic boundary that sends and receives vital information about the state of affairs inside and outside the cell.
Ants first marched into Danny Reinberg’s world about four years ago as he began thinking about taking his lab in a new direction. Now, he cannot keep ants off his mind because they are the focal point of a newly funded HHMI Collaborative Innovation Award to study whether epigenetics influences the behavior and aging of ants.
In mammals, cells carry out their work driven by two copies of nearly every gene, one inherited from each parent. If something happens to one gene, the other is usually there to compensate. But for a small number of genes, the two copies rule does not apply. For those genes, only one parent’s copy is turned on,and the other is shut off. This regulatory process leaves little room for error because there is no gene to act as a backup if problems arise.
Nearly 70 million people worldwide have glaucoma, an insidious group of diseases that damages the optic nerve and leads to vision loss and blindness. High intraocular pressure, which damages nerve cells in the eye, is one of the biggest known contributing factors in the development of glaucoma.
HHMI broadens its research support with the announcement of a new program to foster collaboration and innovation.
HHMI announces the names of scientists selected to pilot a new program devoted to supporting transformative, collaborative research.
Researchers have traced the sequence of metabolic events that kill E. coli bacteria when they are treated with the antibiotic gentamicin.
New images from HHMI scientists show the stunning dynamics of HIV reverse transcriptase zooming around on the very DNA it is building.
A tiny RNA switch may play a big role in the spread of prostate cancer.
Researchers have discovered three genetic factors that could help doctors identify people who are at the greatest risk for developing a brain aneurysm.
Al escudriñar los genomas de más de 10.000 personas, unos investigadores han descubierto tres factores genéticos que podrían ayudar a que los doctores identifiquen las personas que tienen el mayor riesgo de desarrollar una aneurisma cerebral.
Researchers have developed a method for systematically screening cancer cells to detect genes likely to suppress metastasis.
Researchers have identified the chief motor protein that hauls the building materials needed for learning to their destinations inside neurons.
A new technique factors a protein's flexibility into the drug design equation. It's paying off in a big way.
New technology makes it possible to study tissue samples locked away for decades.
Nueva tecnología hace posible el estudio de muestras de tejidos guardadas por décadas.
New studies show how the brain changes when mice learn to feel safe and secure in situations that would normally make them anxious.
Roger Tsien, Osamu Shimomura, and Martin Chalfie honored for the discovery and development of the green fluorescent protein, a ubiquitous research tool.
Roger Tsien, Osamu Shimomura and Martin Chalfie son galardonados por el descubrimiento y desarrollo de la proteína fluorescente verde, que es una herramienta general de investigación.
HHMI researchers devise prenatal blood test that accurately detects Down syndrome and two other serious chromosomal defects.
Investigadores del HHMI desarrollan un nuevo análisis de sangre prenatal que detecta con precisión el síndrome de Down y otros dos defectos cromosómicos serios.
HHMI researchers have found microRNAs in animal species whose last common ancestors were present on Earth about 1 billion years ago.
HHMI researchers have developed a new model of cystic fibrosis in pigs that more accurately mimics features of the disease.
Investigadores del HHMI han desarrollado un nuevo modelo de fibrosis quística en cerdos que imita de forma más precisa las características de la enfermedad que se observa en infantes humanos.
Researchers have identified a gene from a new family of ion channels that help to regulate smell and taste sensing, smooth muscle contraction, and fluid secretion in glands and airways.
A newly identified "hot line" connects a worm's nervous system to its immune system.
Investigadores han descubierto una “línea directa” de comunicación que le permite al sistema nervioso de un gusano llamar al sistema inmune para coordinar la respuesta a patógenos infecciosos.
Researchers have learned how Listeria crosses the placenta from mother to baby.
Researchers have devised clever techniques to visualize gene silencing in its natural context.
A gene deletion caused mice to exhibit behavioral and brain changes common in people with Alzheimer's disease or dementia.
Researchers may be able to fight malaria by targeting human liver cells instead of parasites
Las drogas contra la malaria existentes atacan al parásito que causa la enfermedad, pero están perdiendo eficacia debido al aumento en la resistencia a drogas. Investigadores del Instituto Médico Howard Hughes informan que podrían ser capaces de combatir la malaria atacando células humanas hepáticas en lugar de a los parásitos.
A immunosuppressant drug may unexpectedly fight the parasite-caused disease.
Scientists have detected a multitude of broken, missing, and overactive genes in the most detailed genetic survey yet of any human tumor.
Mediante el examen genético más detallado de cualquier tumor humano que se haya realizado hasta el momento, científicos encuentran que en tumores pancreáticos y cerebrales una variedad de genes están rotos, hiperactivos o desaparecen.
Researchers have generated insulin-producing beta cells from adult pancreatic cells in living mice.
Investigadores del HHMI han transformado células pancreáticas adultas en células betas productoras de insulina en ratones vivos.
Researchers have begun scouring cancer cells for potential sites of resistance against a new class of drugs.
Researchers have shown that bacterial communication can be intercepted and chemically manipulated to control group behavior, such as virulence or the production of a useful products.
Researchers have converted cells from individuals with ten different diseases, including muscular dystrophy, juvenile diabetes, and Parkinson's disease, into stem cells.
Scientists have identified more than 300 human genes that influence West Nile virus infection. More than 20 of these cooperate with the virus, whereas the others help cells resist it.
Researchers have used new technology to pinpoint a critical gene mutation in worms in only a few weeks. It would have taken years for scientists using older technology to sift through the worm's DNA until they found the proverbial needle in the haystack.
Researchers have identified a genetic defect that makes some children susceptible to attack by a certain type of bacteria, a finding that will speed up diagnosis and treatment.
Investigadores del HHMI han identificado dos drogas que imitan muchos de los efectos fisiológicos del ejercicio.
HHMI researchers have identified two drugs that mimic many of the physiological effects of exercise.
Researchers have revealed an important step in the process that guides neurons as they establish precise connections between the spinal cord and muscles.
An international team of researchers has identified a gene mutated in Duane syndrome, a common disorder that restricts the movement of the eyes.
Thanks to a set of fruit flies that seem to get by with far less dozing than most, researchers has found a gene absolutely necessary for snoozing.
By focusing on large families in which both parents share a recent ancestor, scientists have honed in on rare mutations that had remained elusive in previous studies.
HHMI-supported scientists have created MitoCarta, an online atlas of more than 1,000 proteins that healthy mitochondria use to keep cells running smoothly—a tool that should help researchers understand what happens when things go wrong.
HHMI international scholar Alan Cowman has set out to understand the proteins that oversee malaria's destruction and rebuilding of red blood cells.
Scientists may be able to stave off influenza infection by targeting one of more than 100 proteins inside host cells on which the virus depends.
New research has uncovered the mechanism that guides vertebral development in the early embryo.
HHMI researchers have developed a mouse model of osteosarcoma, the most common form of bone cancer.
A new model reveals that three classes of HIV drugs inhibit the virus more than 10,000 times better than others
Nuevo modelo matemático revela que tres clases de drogas contra el VIH inhiben al virus 10.000 veces mejor que otras.
Researchers have identified a chemical messenger that helps different sites on individual neurons coordinate with one another.
Scientists have demonstrated how protocells might have taken up nutrients from the earth's early environment to propel their growth.
Scientists have discovered that the mutation that causes Rett syndrome interferes with the regulation of 2,500 other genes.
A protein previously thought to identify only colon cancer stem cells is actually prevalent throughout primary colon tumors.
A prominent protein on the surface of liver cells protects organisms during sepsis, one of the most common and deadly side effects of bacterial infection.
HHMI researchers bring the arcane world of protein folding to the online gaming arena with the launch of "Foldit."
Investigadores del HHMI acercan el arcano mundo del plegamiento proteico al terreno de juegos en Internet con el lanzamiento de “Pliégalo”.
Researchers have produced the first high-resolution map showing the structural variation that exists in the human genome.
A mutant RNA may be partially to blame for the neurodegeneration associated with spinocerebellar ataxia type 3.
Vision has improved in all three patients who have received gene therapy for a rare but severe form of retinal degeneration.
Just three years after discovering a genetic mutation that causes a trio of leukemias, HHMI researchers have helped move a new leukemia drug into clinical trials.
HHMI researchers identify rare mutations in three genes that contribute to blood pressure variation in the general population.
Investigadores del HHMI han encontrado que mutaciones raras en tres genes contribuyen a variaciones en la presión arterial de la población general.
A new picture of a genetic parasite is helping researchers see how specialized segments of RNA escape from their positions in the genome and invade new ones.
New studies provide a fresh view of the computational power of neurons.
Researchers have identified hundreds of genes that keep embryonic stem cells in their characteristic malleable state.
Researchers have designed and built two functional enzymes never seen in nature.
Con la ayuda de la donación de tiempo computacional de miles de personas en todo el mundo, Investigadores del HHMI han diseñado y construido dos enzimas funcionales nunca antes vistas en la naturaleza.
A cellular gatekeeper inside a malaria parasite doesn't care whether the amino acid letters on a protein's entry ticket are out of order.
Researchers studying spinocerebellar ataxia have uncovered a pathological mechanism that may also underlie more common neurological diseases.
HHMI announces a major new program that will provide much-needed support to some of the nation's best early career faculty.
View the complete list of eligible institutions.
Metastatic colon cancers carry the ability to metastasize from the time they become cancerous, and don't need to acquire any new genetic mutations to become metastatic.
A fruit fly's misguided neurons provide a fascinating look at the evolution of systems that detect carbon dioxide.
People who lack a certain large segment of DNA have a previously unrecognized syndrome characterized by mental retardation, seizures, and slight physical abnormalities.
HHMI researchers have developed novel techniques and software that will provide scientists with the tools they need to decipher large-scale patterns in the vital - but little-understood - process of DNA methylation.
Investigadores del HHMI han desarrollado técnicas y software nuevos que les proveerán a los científicos de las herramientas necesarias para descifrar patrones de metilación a gran escala en el vital –pero poco entendido– proceso de metilación de ADN.
Malaria-causing parasites evade the immune system by ducking in and out of cells.
Certain regions inside the nucleus can prevent the genes inside them from becoming activated.
HHMI researchers have uncovered a protein that stops the growth of melanoma.
A new microscopy technique allows researchers to examine the complete three-dimensional morphology of many of the tiniest structures of cells.
Investigadores del HHMI descubren una proteína que detiene el crecimiento del melanoma.
A study that examined the activity of one plant species' 22,000 genes over a complete day and night cycle showed that midnight is a special time that plants can actually distinguish.
HHMI investigators are beginning to examine every gene in the genome to figure out which genes are deleterious to tumor cells.
The birth of new neurons appears to facilitate certain types of complex learning.
HHMI researchers have revealed how a molecule-munching enzyme helps maintains the internal highways found in cells.
The body's immune system can use a surprisingly common molecule to recognize prostate tumors.
Researchers have identified 273 host proteins that serve to keep the AIDS virus healthy and happy as it infects cells.
Researchers have identified small pieces of RNA that suppress the spread of breast cancer to the lungs and bone.
New research has found that many of the symptoms of fragile X syndrome can be eliminated in mice by reducing the expression of a single gene.
Researchers have a new picture of how neurons forge physical connections between one another in order to communicate.
Even short bursts of activity in a few neurons can influence learning and decision making.