A new method for rapidly identifying genes that are crucial for survival of bacteria cuts the time it takes to pinpoint promising new drug targets from years to weeks.
En el mundo de aminoácidos que en su mayoría es “izquierdo”, las versiones “derechas” de algunas de estas moléculas actúan como señales que pueden estimular la adaptación de las bacterias a cambios en las condiciones ambientales.
In the overwhelmingly left-handed world of amino acids, the right-handed versions of a few such molecules act as signals that spur bacteria to adapt to changing conditions.
HHMI investigators Brian Druker and Charles Sawyers will join Nicholas Lydon, formerly of Novartis, in receiving the 2009 Lasker~Debakey Clinical Medical Research Award.
A new genetically encoded switch lets researchers use light to control a cell’s shape and movement.
The sentinels of the immune system possess a hidden strength that may be used to improve vaccine design for tough-to-beat bugs.
The method Google uses to rank the importance of web pages can help identify the species whose extinction would most likely trigger an ecosystem’s collapse.
A new imaging technique will allow scientists to focus on the tiny structures that mediate communication between neurons within relatively intact samples of brain tissue.
Variations in the ways abnormal proteins fit together to form the long amyloid fibrils associated with many diseases may represent a protein-based system of inheritance that parallels the genetic code.
Researchers have identified two molecular keys that help release salts from cells, keeping them alive in the ever-changing salinity of their environment.
Researchers have learned how a molecular switch helps the immune system to keep cancer in check by promoting the destruction of abnormal blood cells.
Interfering with communication among bacteria can prevent them from mounting a unified assault on their host.
A new study shows that most early ovarian tumors exist for years at a size that is a thousand times smaller than existing tests can detect reliably.
Un nuevo estudio muestra que la mayoría de los tumores ováricos en estadios tempranos tienen, durante años, un tamaño que es mil veces más pequeño del que los análisis existentes pueden detectar con confiabilidad.
Tiny, hair-like projections called cilia sense bitter material in the airways and help expel it.
An HHMI-funded graduate student and her colleagues have found that some chimps infected with the primate form of HIV develop AIDS-like symptoms and die early.
New clues narrow the search for the underlying cause of a serious congenital heart defect.
Lung cancer cells hijack a master cellular signal and use it to seed deadly new tumors in the brain, bone marrow, and other organs.
New evidence suggests that damage to nerve cells in people with MS accumulates because the body's mechanism for repairing the nerve coating called myelin stalls out.
Researchers have identified two proteins that begin to explain how radically slashing calories leads to a longer life.
Joan Massagué honored for elucidating one of the fundamental processes that control cell division.
A new method will speed the identification of the targets of microRNAs—the tiny but powerful bits of nucleic acid that tweak gene expression to influence many aspects of health and human disease.
HHMI is expanding collaborations with the Jane Coffin Childs Memorial Fund, the Helen Hay Whitney Foundation, the Damon Runyon Cancer Research Foundation, and the Life Sciences Research Foundation to increase support for outstanding postdoctoral researchers.
New research shows that a father’s sperm passes along a previously unrecognized set of instructions that helps guide the early development of his children.
A new molecular portrait of rotavirus may help researchers design more effective vaccines against the lethal gastrointestinal infection that kills 500,000 children annually.
A new microscopy technique is enabling researchers to capture videos of fast-moving cellular processes with super high resolution.
New research indicates that in most cases, natural selection may shape the human genome much more slowly than previously thought.
HHMI researchers identify many potential new drug targets for cancers long deemed "untouchable."
Research suggests new avenues to treat or prevent infections by parasitic worms.
A protein often accused of sparking autoimmune disease can suppress the onset of inflammatory bowel disease.
HHMI scientists have taken a major step towards understanding the molecular mechanisms that transform Listeria monocytogenes from a harmless soil-dweller to a dangerous human pathogen by mapping the genes that Listeria expresses under different environmental conditions.
Horvitz's election to the Fellowship of the Royal Society recognizes his exceptional contributions to science.
Ultraviolet radiation from the sun can zap DNA, damage cells, and set the stage for the subsequent development of cancer. Scientists have now identified the built-in safety mechanism that forces some cells damaged by UV radiation to commit suicide so they do not perpetuate harmful mutations.
La radiación ultravioleta del sol puede destruir el ADN, dañar las células y predisponer al organismo para el desarrollo subsecuente de cáncer. Unos científicos han identificado el mecanismo de seguridad intrínseco que fuerza a algunas células dañadas por la radiación UV a cometer suicidio para no perpetuar mutaciones dañinas.
The movement of blood through the aorta of a developing embryo triggers the production of new blood stem cells.
Scientists have identified a protein that hampers learning and memory by keeping DNA inside neurons tightly coiled.
Genetic clues suggest how invasive breast cancer cells pry their way into the tightly protected interior of the brain.
With the emergence of a new strain of influenza A(H1N1), scientists have a unique opportunity to study viral evolution in action.
The pulsing of a single neuron can switch a brain’s waves from the equivalent of a big ocean swell to ripples on a pond.
La pulsación de una sola neurona puede cambiar las ondas cerebrales de forma equivalente a lo que sería transformar las ondas del oleaje marino en las pequeñas ondas que se pueden observar en una laguna.
A new strategy for generating plug-and-play components could make life easier for synthetic biologists.
Two critical genes that serve as beacons and give cells a much needed sense of direction in the chaotic days of early development have been identified by HHMI researchers at the University of Toronto.
HHMI will challenge research universities to develop compelling new ways to show undergraduate students the excitement and creativity of science by inviting nearly 200 top institutions to compete for individual grants of up to $2.2 million. HHMI plans to award up to $85 million in total grants.
A new therapy for metastatic prostate cancer has shown considerable promise in early clinical trials involving patients whose disease has become resistant to current drugs.
HHMI researchers have designed tiny RNA molecules that shut off the gene that causes Huntington’s disease without damaging that gene’s healthy counterpart, which maintains the health and vitality of neurons.
An international scientific challenge is being launched to speed development of new tools that accurately and automatically reconstruct the shape of brain cells from microscopy data.
Researchers have identified a group of genes that influence a person's sensitivity to radiation.
A new type of scaffold for growing human cells mimics conditions inside the body better than flat Petri dishes.
A gene strongly implicated in schizophrenia is essential for normal brain development and the growth of new neurons in the adult brain.
Una mejor protección podría provenir de una vacuna contra el VIH que haga que el cuerpo produzca un “enjambre” de anticuerpos naturales.
Better protection might come from an HIV vaccine that induces the body to produce a "swarm" of natural antibodies.
Scientists have discovered sensory neurons within the antennae that help flies respond to wind.
Small genomes are cheaper to sequence and lack the repetitive "junk" that clutters bigger genomes—but a new study suggests that bigger genomes are better for figuring out how genes are controlled.
Researchers have taken a major step toward developing a better animal model of human AIDS by genetically modifying HIV so that it can infect a species of rhesus monkeys.
Scientists have mapped previously unknown pathways in yeast cells that link the overactivity of a mysterious gene to the death of nerve cells in Parkinson's disease.
A new tool reveals the identity and quantity of every protein produced by a living cell at any given time.
Researchers have identified a marker present in the urine of patients with prostate cancer that indicates whether the cancer is progressing and spreading.
Investigadores han identificado un nuevo marcador biológico que se encuentra presente en la orina de pacientes con cáncer de próstata que indica si el cáncer está progresando y se está diseminando.
HHMI researchers and their colleagues unveil the first comparative map of four primate genomes.
Blood platelets can destroy deadly malaria parasites. But a single dose of aspirin may be enough to thwart their killing power.
Nuevos estudios en ratones sugieren que las plaquetas sanguíneas pueden destruir los mortales parásitos de la malaria. Pero una única dosis de aspirina puede interferir con las plaquetas de forma suficiente como para impedir su poder letal.
The shapes of some of the tiniest cellular structures are coming into sharper focus at Janelia Farm, where scientists have developed a new imaging technology that produces the best three-dimensional resolution ever seen with an optical microscope.
Rajesh Gokhale has created a compound in his lab in India that stops tuberculosis by hitting four of the bacterium's crucial metabolic pathways at the same time.
Researchers have discovered a new form of cellular memory that appears to help immune cells "learn" from past encounters with pathogens so they can combat them more effectively the second time around.
Researchers have created an efficient way to detect genes that have been inappropriately fused together, a type of genetic abnormality that spurs the growth of blood and prostate cancers.
A novel kind of odor-detecting protein may explain some of the gaps in researchers' knowledge of how insects smell.
Una nueva clase de proteínas de detección de olores puede explicar algunas de las lagunas en el conocimiento que tienen los investigadores sobre cómo los insectos detectan los olores.
HHMI researchers track down the genes responsible for establishing the characteristic swirl of a snail shells.
A new microscopy technique that uses the principles underlying holography is helping researchers speed up imaging and optically manipulate living cells.
New ways of imaging sugar molecules are creating a vibrant new biological frontier.
A 20 year search has helped international research scholar Hugo D. Luján explain how the Giardia parasite hides from the immune system.
Al igual que una pandilla de bandidos que se cambia la ropa después de un robo para evitar ser capturados, el parásito intestinal Giardia lamblia altera su aspecto para engañar al sistema inmune humano. Después de una búsqueda de 20 años, experimentos realizados por el Becario Internacional de Investigación del Instituto Médico Howard Hughes, Hugo D. Luján, revelan cómo cambia sus disfraces el parásito.
Starved cone cells in the eye may nibble themselves to death in people with retinitis pigmentosa.
Una de las razones por las que mueren las células responsables de la visión de los colores en personas con retinitis pigmentosa puede ser que las células se comen a sí mismas cuando son privadas de nutrientes.
At least one of every four melanoma cells has the capacity to seed the development of new tumors.
By manipulating a newly identified regulatory protein, researchers can reactivate a dormant fetal hemoglobin gene--possibly with therapeutic benefits for patients with life-threatening anemias.
Scientists have created a new mouse model that may help explain how a rare disease causes otherwise supple soft tissue and joints to turn into bone.
HHMI researchers have uncovered a molecular explanation for the profound fatigue brought on by mild exercise in some people with muscular dystrophy.
Researchers have identified a molecule that tells your brain when it's time to say no to a second piece of pie and push back from the Thanksgiving table.
Investigadores identifican una molécula que le dice al cerebro que ha llegado el momento de decirle no a un segundo pedazo pastel de calabaza y alejarse de la mesa del Día de Acción de Gracias.
Susan Lindquist believes that if “personalized medicine” for complex neurodegenerative disorders is to become a reality then scientists must begin developing more rigorous approaches to identifying and validating promising new therapies.
Images in biology textbooks may give the misleading impression that the cell membrane is a passive envelope that does little more than keep the cell’s internal contents in place. Howard Hughes Medical Institute researcher Douglas C. Rees prefers to think of the outer membrane of human cells as a dynamic boundary that sends and receives vital information about the state of affairs inside and outside the cell.
Ants first marched into Danny Reinberg’s world about four years ago as he began thinking about taking his lab in a new direction. Now, he cannot keep ants off his mind because they are the focal point of a newly funded HHMI Collaborative Innovation Award to study whether epigenetics influences the behavior and aging of ants.
In mammals, cells carry out their work driven by two copies of nearly every gene, one inherited from each parent. If something happens to one gene, the other is usually there to compensate. But for a small number of genes, the two copies rule does not apply. For those genes, only one parent’s copy is turned on,and the other is shut off. This regulatory process leaves little room for error because there is no gene to act as a backup if problems arise.
Nearly 70 million people worldwide have glaucoma, an insidious group of diseases that damages the optic nerve and leads to vision loss and blindness. High intraocular pressure, which damages nerve cells in the eye, is one of the biggest known contributing factors in the development of glaucoma.
HHMI broadens its research support with the announcement of a new program to foster collaboration and innovation.
HHMI announces the names of scientists selected to pilot a new program devoted to supporting transformative, collaborative research.
Researchers have traced the sequence of metabolic events that kill E. coli bacteria when they are treated with the antibiotic gentamicin.
New images from HHMI scientists show the stunning dynamics of HIV reverse transcriptase zooming around on the very DNA it is building.
A tiny RNA switch may play a big role in the spread of prostate cancer.
Researchers have discovered three genetic factors that could help doctors identify people who are at the greatest risk for developing a brain aneurysm.
Al escudriñar los genomas de más de 10.000 personas, unos investigadores han descubierto tres factores genéticos que podrían ayudar a que los doctores identifiquen las personas que tienen el mayor riesgo de desarrollar una aneurisma cerebral.
Researchers have developed a method for systematically screening cancer cells to detect genes likely to suppress metastasis.
Researchers have identified the chief motor protein that hauls the building materials needed for learning to their destinations inside neurons.
A new technique factors a protein's flexibility into the drug design equation. It's paying off in a big way.
New technology makes it possible to study tissue samples locked away for decades.