El parásito intestinal Giardia lamblia cambia de vestimenta casi tan frecuentemente como una modelo en una pasarela parisina, pero su amplio guardarropa de proteínas superficiales podría en realidad ser su propia perdición. Parásitos Giardia diseñados para que expresen todas sus proteínas de superficie se comportaron como vacunas que podrían ayudar a prevenir o a atenuar futuras infecciones intestinales.
A Giardia parasite engineered to express its extensive wardrobe of surface proteins worked as a vaccine that could help prevent or mitigate future intestinal infections.
By switching off a single gene, researchers have created mice that behave much like people with obsessive-compulsive disorder. The animal model could help scientists design new therapies for the debilitating condition.
Some bacteria take over cells by interfering with an important process called SUMOylation, which helps cells respond to stress.
On May 26, Egnor will give a free public lecture titled, "Whistling in the Dark: What Can Mouse Vocalizations Tell Us about the Brain?"
Scientists have uncovered thousands of DNA segments that were missing from the reference sequence of the human genome.
A molecule best known for fighting off cellular clutter is now recognized as an important defender against another cellular threat: viruses.
New research provides details of how genetic mismanagement by RNA can lead to a human disease—in this case, breast cancer.
New research suggests that training to do a new task causes groups of brain cells to “learn” how to work together more efficiently.
A new discovery shows how wing spots evolved in a species of polka-dotted fruit fly, and underscores the concept that evolution likes to tinker with existing genetic machinery.
Kaelin is one of five scientists honored with the 2010 Canada Gairdner International Award in recognition of their contributions to medical science.
New research reveals how genetic and environmental factors influence an organ that has not traditionally taken much of the blame for diabetes and cardiovascular disease.
Researchers have identified key cells involved in zebrafish heart regeneration and begun to decipher the instructions the cells use to carry out their work.
New studies of how the heart develops in mouse embryos have brought researchers closer to understanding how to induce the body’s own cells to rebuild damaged arteries.
Scientists have found several new ways to kill M. tuberculosis, which could lead to the development of alternative drugs.
An ambitious survey has identified differences in the binding of master regulators called transcription factors that affect how genes are expressed in different people.
In a discovery that may one day aid law enforcement in identifying suspects, researchers have found that skin bacteria left behind on keyboards and computer mice can identify the objects’ users.
A new software package promises to greatly speed up scientists’ ability to assemble and manipulate extremely detailed microscope images.
Experiments with an artificial cell surface demonstrate that a tumor’s aggressiveness is strongly correlated to its mechanical pulling power.
New findings about an often fatal neurodegenerative disease suggest that helping a beneficial protein linger a little longer could promote neuron survival.
Researchers have discovered how one New World hemorrhagic fever virus latches onto and infects human cells, offering a much-needed lead toward new treatments.
Las fiebres hemorrágicas del Nuevo Mundo son enfermedades infecciosas emergentes que se encuentran en Sudamérica y que pueden causar síntomas terribles, similares a los del Ébola. Investigadores del HHMI han descubierto exactamente cómo un virus de fiebre hemorrágica del Nuevo Mundo se adhiere e infecta a las células humanas, lo que ofrece una pista muy necesaria para lograr nuevos tratamientos.
Jean-Philippe Vielle-Calzada, becario internacional de investigación del Instituto Médico Howard Hughes (HHMI), se preguntó si podría aprender lo suficiente sobre la genética de la reproducción asexual para aplicarla a las plantas que se producen sexualmente.
An HHMI scientist has moved a step closer to turning sexually-reproducing plants into asexual reproducers, a finding that could have profound implications for agriculture.
Endothelial cells keep blood stem cells dividing healthily in a lab dish much longer and more effectively than previous methods of growing the cells.
A new study suggests that gut microbes might one day be grouped along with inadequate exercise and overeating as a cause of obesity and metabolic syndrome.
The mitochondrial genome, long thought to be nearly identical in every cell in the human body, actually varies to a surprising degree.
At the AAAS Annual Meeting, David Anderson discussed how studies of model organisms such as mice and fruit flies can improve scientists' understanding of the neural basis of emotion.
At the AAAS Annual Meeting on Feb. 20, Owen Witte discussed a new tool to understand how cancers grow—and with it a new opportunity to identify novel cancer drugs.
At the AAAS Annual Meeting on Feb. 20, George Daley described the current climate facing stem cell researchers in the United States.
Researchers have created a group of stem cells from patients who have a disorder that causes accelerated aging and bone marrow failure. Using a genetic reprogramming technique to “turn back the molecular clock” in these cells appears to reset the cells and reverses rapid aging.
A new vaccine tested in 100 West African children triggers the immune system to produce antibodies against the malaria parasite at levels normally seen only in adults who have strong resistance to the disease.
Una nueva vacuna que se probó en 100 niños de África Occidental hizo que el sistema inmune produjera anticuerpos contra el parásito de la malaria en niveles que normalmente sólo se observan en adultos que tienen una fuerte resistencia a la enfermedad.
With a collection of tools for rapidly processing changing visual cues, the eyes and brain work together to create meaningful images from raw signals.
Researchers have found the key factors that cause proteins to turn into sticky, fibrous clumps that can grind cellular activity to a halt.
Two groups of HHMI scientists working independently have identified a critical enzyme that allows a malaria-causing parasite to take over and thrive in human red blood cells.
Dos grupos de científicos del HHMI que trabajaban de forma independiente han identificado una enzima crítica que permite que el parásito que causa la malaria controle los glóbulos rojos sanguíneos humanos y prospere en el interior de los mismos.
Researchers have discovered that when DNA-copying machines run head-on into oncoming traffic, they kick the obstacles out of their way.
With the discovery of a sodium taste receptor, researchers have now identified the molecular receptors, cells, and coding logic for all five basic tastes.
HHMI researchers have developed a new method for growing human liver cells outside the body, which may boost efforts to develop a vaccine or treatment for hepatitis C infection.
Researchers have devised a new method that increases the number of blood vessel-forming cells they can make from human embryonic stem cells.
Investigadores han demostrado que distintas mutaciones que causan cáncer en células vecinas pueden cooperar para producir tumores.
Researchers have shown that distinct cancer-causing mutations in neighboring cells can cooperate to produce tumors.
Researchers have new information about how proteins called Argonautes bind to small RNAs and selectively shut down protein production.
Scientists have identified the genetic cause of a rare eye movement disorder and found that specific mutations in the disease gene can cause additional errors in neurodevelopment and neuronal survival.
A newly identified enzyme could help scientists create stem cells and arrest the growth of cancers by giving them the ability to wipe clean cells' developmental slates.
Terrible and swift as anthrax appears to its victims, the deadly toxin takes its time breaking into their cells. The entry of anthrax toxin into its cellular target is part of a carefully-planned, two-pronged attack, scientists have found.
Gerald M. Rubin, director of the Howard Hughes Medical Institute’s Janelia Farm Research Campus, will deliver a public lecture titled “The Fly Brain and Yours—Closer Than You Think,” at Janelia Farm in Ashburn, VA.
Janelia scientists have borrowed a technique from the field of astronomy to overcome biology’s equivalent of the twinkling of stars and the shimmering mirages in desert landscapes.
A small but aggressive fraction of metastatic cancer cells can re-infiltrate the original tumor, boosting its malignant potential.
Una fracción pequeña pero agresiva de células cancerígenas puede reinfiltrar el tumor original, aumentando su potencial maligno.
From the brain's point of view, not every itch is the same. HHMI researchers have identified a new type of itch receptor.
In a tour-de-force of evolutionary sleuthing, researchers have traced a yellow-to-black color change in African fruit flies to five single-letter genetic mutations.
Researchers have identified a naturally occurring human protein that helps prevent infection by H1N1 influenza and other viruses, including West Nile and dengue virus.
A newly identified gene mutation is one of only a handful of mutations outside the X chromosome to be linked to intellectual disability.
A new method for strengthening proteins could lead to improved laundry soap, better nanotechnology, and less expensive cancer drugs.
Comparing the DNA of fish with and without spiny pelvic hindfins provides evidence that evolution can leap rather than shuffle.
Using advanced electron-microscopy and modeling techniques, a team of researchers has determined the structure of a eukaryotic ribosome with unprecedented accuracy.
Scientists have discovered a new type of stem cell in the skin that acts surprisingly like certain stem cells found in embryos: both can generate fat, bone, cartilage, and even nerve cells. These newly-described dermal stem cells may one day prove useful for treating neurological disorders and persistent wounds, such as diabetic ulcers.
HHMI researchers have identified a new factor necessary for the development of medulloblastomas, the most common type of malignant childhood brain cancer.
A protein found in the saliva of ticks may prove to be an attractive target for a new type of Lyme disease vaccine.
Scientists have found that preeclampsia can dramatically increase the likelihood that a woman will experience low thyroid function later in life.
Researchers have developed a new imaging method to track how a person’s brain divides up duties between the two halves.
A new imaging tool lets researchers watch individual neurons in the brains of living animals light up as they work together to control the animal’s behavior.
Scientists have an ambitious new strategy for untangling the evolutionary history of humans and their biological relatives: obtain, preserve, and sequence the DNA of approximately one species for each genus of living mammals, birds, reptiles, amphibians, and fish.
Variations from DNA's iconic double-helix shape transmit information about where proteins need to bind to make sure the right genes are activated or silenced during development.
New research shows that histones that escape from cells aren’t just a byproduct of sepsis, they’re a ringleader in its development.
Cutting down the amount of fat particles in cells may be an effective way to prevent the dengue fever virus from replicating and spreading.
Nueva investigación muestra que el reducir la cantidad de partículas grasas de las células podría ser una forma eficaz de evitar que el virus de la fiebre del dengue se replique y disemine.
A signaling pathway that guides the early development of animals from flies to humans also helps a regenerating flatworm orient itself from head to tail.
José A. Rodriguez, estudiante doctoral financiado por el HHMI en la Universidad de California en Los Ángeles y un equipo multidisciplinario de colegas han encontrado que el parásito Trypanasoma brucei, que causa la enfermedad africana del sueño, no se mueve en sólo una dirección como un sacacorchos.
New research by an HHMI-funded graduate students and his colleagues has overturned an 150-year-old idea of how the parasite Trypanasoma brucei moves. T. brucei causes African sleeping sickness.
Por primera vez, científicos han diagnosticado una enfermedad genética secuenciando completamente todos los genes de un paciente.
For the first time, scientists have diagnosed a genetic disease by completely sequencing all of a patient’s genes.
New research shows how the taste of carbonation is perceived.
New research shows that a protein that stabilizes DNA does a lot of slipping and sliding as it wrestles the molecule into place.
Thomas A. Steitz, Venkatraman Ramakrishnan y Ada E. Yonath son los galardonados con el Premio Nobel de Química de 2009 por sus estudios sobre la estructura y función del ribosoma.
Thomas A. Steitz, Venkatraman Ramakrishnan, and Ada E. Yonath awarded the 2009 Nobel Prize in Chemistry for studies of the structure and function of the ribosome.
HHMI researcher Jack Szostak wins 2009 Nobel Prize in Physiology or Medicine.
La Real Academia de Ciencias Sueca anunció que Jack W. Szostak, Elizabeth Blackburn y Carol Greider fueron galardonados con el Premio Nobel 2009 de Fisiología o Medicina el descubrimiento de cómo los cromosomas son protegidos por los telómeros y la enzima telomerasa.
A study examining the letters of 16 well known writers, performers, politicians, and scientists shows that the factors that determined their correspondence patterns are the same factors that shape emailing patterns today.
In evolution, proteins can’t go home again—at least not by their original route.
A new method for rapidly identifying genes that are crucial for survival of bacteria cuts the time it takes to pinpoint promising new drug targets from years to weeks.
En el mundo de aminoácidos que en su mayoría es “izquierdo”, las versiones “derechas” de algunas de estas moléculas actúan como señales que pueden estimular la adaptación de las bacterias a cambios en las condiciones ambientales.
In the overwhelmingly left-handed world of amino acids, the right-handed versions of a few such molecules act as signals that spur bacteria to adapt to changing conditions.
HHMI investigators Brian Druker and Charles Sawyers will join Nicholas Lydon, formerly of Novartis, in receiving the 2009 Lasker~Debakey Clinical Medical Research Award.
A new genetically encoded switch lets researchers use light to control a cell’s shape and movement.
The sentinels of the immune system possess a hidden strength that may be used to improve vaccine design for tough-to-beat bugs.
The method Google uses to rank the importance of web pages can help identify the species whose extinction would most likely trigger an ecosystem’s collapse.
A new imaging technique will allow scientists to focus on the tiny structures that mediate communication between neurons within relatively intact samples of brain tissue.
Variations in the ways abnormal proteins fit together to form the long amyloid fibrils associated with many diseases may represent a protein-based system of inheritance that parallels the genetic code.
Researchers have identified two molecular keys that help release salts from cells, keeping them alive in the ever-changing salinity of their environment.
Researchers have learned how a molecular switch helps the immune system to keep cancer in check by promoting the destruction of abnormal blood cells.
Interfering with communication among bacteria can prevent them from mounting a unified assault on their host.
A new study shows that most early ovarian tumors exist for years at a size that is a thousand times smaller than existing tests can detect reliably.
Un nuevo estudio muestra que la mayoría de los tumores ováricos en estadios tempranos tienen, durante años, un tamaño que es mil veces más pequeño del que los análisis existentes pueden detectar con confiabilidad.
Tiny, hair-like projections called cilia sense bitter material in the airways and help expel it.
An HHMI-funded graduate student and her colleagues have found that some chimps infected with the primate form of HIV develop AIDS-like symptoms and die early.
New clues narrow the search for the underlying cause of a serious congenital heart defect.
Lung cancer cells hijack a master cellular signal and use it to seed deadly new tumors in the brain, bone marrow, and other organs.