Designer ion channels that can turn neurons on or off will help researchers understand the connection between behavior and neural circuitry.
The first definitive proof of a weak spot in the parasite's apicoplasts—organelles with ancient plant origins—offers hope for drugs and vaccines against malaria.
New research has classified vertebrate evolution in relation to periods of evolution marked by changes in specific kinds of genes.
Protective chemicals known as interferons may identify themselves by how tightly they grip their receptor at various attachment points.
An HHMI-funded researcher has used online gene expression profiles to match old drugs with diseases in need of treatments.
Next-generation sequencing and stem cell technology have helped scientists identify a mutation that causes retinitis pigmentosa.
Understanding of antibody may help scientists design a longer-lasting vaccine against the influenza virus.
A test that detects a cancer-causing fusion gene in men’s urine could help reduce the number of prostate biopsies performed each year.
Two studies reveal genetic mutations often present in the most common form of head and neck cancer, offering a picture of how the cancer develops and how therapeutics could treat it.
A genetic comparison of E. coli strains, including the one responsible for the recent outbreak of infections in Europe, underscores how rapidly evolving bacterial genomes can lead to the emergence of new pathogens.
Altering the balance of excitatory and inhibitory inputs in the brains of mice disrupts the animals' social interactions.
The neurological problems caused by Fragile X syndrome may be due to excess synthesis of certain proteins.
An immune defense protein uses prion-like qualities to fend off viruses.
Small bits of RNA can cause a connective tissue cell from human skin to transform into a nerve cell.
A new understanding of a gene that is commonly mutated in people with myeloid leukemia could help lead to new treatments.
Scientists have used a gene therapy tool that acts like intelligent molecular scissors to correct the key gene defect in mice with hemophilia B.
Fifteen scientists working in the plant sciences gain flexible support from HHMI and the Gordon and Betty Moore Foundation to move their research in creative new directions.
The Howard Hughes Medical Institute (HHMI) and the Gordon and Betty Moore Foundation (GBMF) have selected 15 of the nation’s most innovative plant scientists to join a new initiative that boosts much needed funding for fundamental plant science research.
Simon Chan is a 2001 Plant Science Program HHMI-GBMF Investigator.
New research pinpoints differences between cancer stem cells in squamous cell cancer and normal stem cells in the skin, which could be exploited to create powerful new anti-cancer therapeutics.
A new study helps explain how fruit flies commit details of their surroundings to memory.
Medzhitov shares Shaw Prize for discoveries related to innate immunity.
Joanne Chory and Thomas Steitz have been elected foreign members of the Fellowship of the Royal Society.
A detailed comparison of DNA and RNA in human cells has uncovered a surprising number of cases where the corresponding sequences are not, as has long been assumed, identical.
HHMI scientists suggest that as many as 20 percent of sporadic autism cases can be explained by spontaneous gene mutations.
Científicos del HHMI sugieren que tanto como un 20 por ciento de los casos de autismo esporádico pueden explicarse por mutaciones genéticas espontáneas.
A class of proteins known for its involvement in muscle development, brain connectivity, and cancer has now been found in the liver, where it spurs sugar production when we need it most.
Adult planarians, masters of regeneration, harbor pluripotent stem cells that appear to have the same all-purpose qualities as embryonic stem cells.
The same signaling pathway can both cause and suppress disease in blood cells.
Six HHMI investigators are among the 72 new members and 18 foreign associates elected today.
With a new animal model of angle-closure glaucoma, researchers have pinpointed a gene that may be to blame.
Human cytomegalovirus hijacks an antiviral protein and uses it to enhance infection by slowing down the host cell’s energy production.
Janelia Farm group leader Mats Gustafsson was a leader in the field of structured illumination light microscopy.
Eight Howard Hughes Medical Institute investigators are among those newly elected to the academy.
New data about what drives aortic aneurysm progression in Marfan syndrome will help guide treatment decisions and inform efforts to develop new therapies.
At any given moment, a few neurons are ready to take charge of the next piece of information to be stored in the brain's hippocampus.
The biological basis of schizophrenia is not fully understood, but new research by HHMI international research scholar Michael Salter offers insights into the disruptions in brain chemistry that underlie the debilitating mental illness.
Using chemical genetics to single out a single kinase among the hundreds inside a cell, scientists have gleaned new information about how one such protein might contribute to cancer-promoting signaling.
New maps detailing where certain markers of genetic regulation are found in a variety of cell types will help researchers interpret large-scale analyses.
A zebrafish model of human melanoma has helped scientists identify new targets for potential therapies.
New research offers a genetic explanation for why some patients' lung tumors disappear almost completely when treated with the drug erlotinib, while other patients' responses are far less dramatic.
Searching for a new food source is a big decision for a worm, based on hunger, dining companions, oxygen availability, and, according to a new study, genetics.
The 2011 prize honors Elaine Fuchs, James Thomson, and Shinya Yamanaka for pioneering work in isolating human stem cells.
Flickering black and white movies show components of the spliceosome coming and going from bits of RNA as they await processing.
The clear and watery substance that bathes the brain and spinal cord is enough to support the growth of neural stem cells in the lab.
Specific traits that distinguish humans from their closest living relatives can be attributed to the loss of chunks of DNA that control when and where genes are turned on.
With the flick of a genetic light switch, researchers have reduced symptoms of anxiety in laboratory mice.
A new genetic method for labeling cells transforms the tangles of neurons within the brain of a fruit fly into fantastic rainbows of color.
Janelia researchers create a new microscope that uses a thin sheet of light to reveal the dynamic inner life of cells.
Triple-negative tumors lack three traits that can be targeted by available breast cancer treatments. But new findings suggest treatment possibilities for these aggressive cancers may be at hand.
A newly identified genetic marker appears to predict a diagnosis of post-traumatic stress disorder in women, but not in men.
A rapid new method of blocking gene function is letting researchers dissect how stem cell progenitors in the skin split their energy between creating copies of themselves and crafting specialized new cells.
A corrective strategy used by astronomers to sharpen images of celestial bodies can now help scientists see with more depth and clarity into the living brain of a mouse.
Scientists have used next-generation DNA sequencing tools to identify a mutation in a gene that underlies one of the most common forms of severe hypertension.
Neurons that control aggression and mating are closely intertwined deep within the brain.
Researchers gain a new view of how genes are converted to protein by freezing the action during the earliest stage of the process.
Researchers at Stanford University have discovered that they may be able to tweak cancer cells so that they summon their own demise.
In mice with light-sensitive neurons in their brain, illuminating one type of neuron drives the animals to their food bowls, whereas targeting a different type makes them abstain.
After a rapid genetic analysis of bacteria collected from Haitian patients, scientists conclude that the strain of cholera currently sweeping through post-earthquake Haiti originated in South Asia.
HHMI has launched an international competition to select up to 35 early career scientists working at academic institutions in 18 countries on five continents.
A study in fruit flies shows that turning back the clock on aging muscles delays aging in the whole animal.
Safe and effective vaccines could complement efforts to treat those already infected with cholera and provide clean water and sanitation to control its spread.
A new study has pinned some of the symptoms of Rett syndrome to a set of neurons that usually work to rein in nerve cell firing in the brain.
New research suggests rising temperatures in the highlands of East Africa are at least partly to blame for the increase in malaria transmission in recent decades.
A previously overlooked group of cells has been shown to be essential in helping adult stem cells multiply and revitalize damaged tissue.
Through an international study of the genome in persons who control HIV without the need for medications, scientists have identified a handful of amino acids that seem to predict a person’s ability to successfully keep the virus in check.
Researchers have shown that radiation-resistance among tumor stem cells can be dramatically lowered by heating them up.
A new analysis of gene duplication across the human genome reveals far more variation in gene copy number than anticipated.
Research in mice suggests that manipulating a single molecule might help eliminate fears that have been etched into memory.
A new study reveals that many pancreatic tumors take nearly 20 years to become lethal after the first genetic perturbations appear, suggesting an opportunity for early diagnosis.
A pair of international research scholars has discovered a deep connection between the circadian clocks of plants and animals.
Dos becarios internacionales de investigación descubren una profunda conexión entre el reloj circadiano de plantas y animales: un gen que está involucrado en la creación de formas alternativas de proteínas relacionadas con el ritmo circadiano.
Susan Lindquist, an HHMI investigator, and Stephen Benkovic, a member of HHMI's Scientific Review Board, are among ten recipients of this year's National Medal of Science.
Cellular clocks throughout the body are precisely synchronized by tiny fluctuations in body temperature.
Laboratory studies of planarians' reproductive cycles suggest new strategies for treating infections that affect hundreds of millions worldwide.
Four HHMI investigators, an HHMI early career scientist, and a senior fellow at Janelia Farm have been elected to the IOM.
The discovery of an odd couple of genes that team up to trigger rare and difficult-to-detect gastrointestinal stromal tumors could eventually lead to better diagnostics and treatments.
Researchers are inching their way toward a new HIV vaccine strategy by studying the cells of people who have naturally strong immune defenses against the virus.
HHMI and the Gordon and Betty Moore Foundation announce a new partnership to support some of the nation's most innovative plant scientists.
Jeffrey Friedman and Douglas Coleman are being honored for discoveries that led to the identification of leptin, a hormone that regulates appetite and body weight.
Mutations that supercharge a cellular garbage disposal may explain why cancer cells can thrive even as their genetic material multiplies out of control.
A targeted search combined with today's rapid DNA sequencing technology leads researchers to a genetic culprit for a rare disease.
Researchers have new details of how an enzyme helps bacteria slice up foreign genetic material.
Most of the clear cell ovarian carcinoma samples examined in a new study carried a gene mutation that alters the epigenetics of cells.
HHMI researchers have found that malaria parasites can produce multiple versions of a protein that causes infected blood cells to grab onto the inner wall of blood vessels.
Multiple jury prizes were awarded in recognition of contributions advancing technology to automate an important but tedious component of neuroscience research.
If Howard Chang has his way, there will soon be an iPhone app for dialing in RNA structures.
A handful of antibiotic-resistant bacteria can protect an entire colony.
A rare skin disease provides the first example of a disease-causing mutation that spontaneously reverts, producing healthy skin.
With the help of yeast and fruit flies, researchers have identified a distorted gene that appears to be among the most common genetic risk factors for amyotrophic laterial sclerosis (ALS), the devastating neurodegenerative disease also known as Lou Gehrig's disease.
Health officials have held off from recommending an inexpensive malaria drug for widespread use because of concerns about drug resistance. New research drawn from 10 years of field and laboratory studies suggests the drug may be a safe and effective way to prevent malaria.
HHMI researchers develop tiny life-support packets for therapeutic cells.
A cooperative online game has attracted 50,000 players whose “distributed thinking” has, in some cases, proven more powerful than computers in predicting the structure of proteins.
A type of prostate cell that has been largely ignored by cancer researchers can trigger malignant prostate cancer.
Janelia Farm researchers show it takes steady hands to measure the brain activity of a fruit fly while it is walking.
HHMI researchers discover that induced pluripotent stem cells retain a genetic memory of their tissue of origin.
A protein that is already the target of experimental drugs that aim to extend life is now known to play a key role in learning and memory.
An ambitious new analysis in mice demonstrates that for more than 1,300 genes active in the brain, there is a significant bias as to which copy is active—the one inherited from the mother or the one that came from the father.
Researchers have identified signaling pathways by which the normal prion protein switches on the general protein synthesis necessary to promote the growth and development of brain cells.
A new imaging method will allow researchers to study speedy cell processes over hours and days rather than seconds, and to examine how morphological defects arise in developing animals.