HHMI researchers have found the first hereditary human sleep disorder that is caused by a single gene. The disorder is passed from generation to generation in the same simple pattern characteristic of traits such as eye color.
A team of biologists has determined the three-dimensional structure of an enzyme that allows certain bacteria to resist the killing effects of the antibiotic gentamicin. The structure is also shared by a number of proteins involved in basic biological processes, including circadian rhythms and gene regulation.
A genetic mutation common in the most severe forms of muscular dystrophy also predisposes to heart damage.
Two genes that generate the immune system's remarkable diversity are controlled by the same small piece of DNA.
Mice born without a gene that regulates appetite exhibit unexpected attacks of narcolepsy.
A two-tiered boost to the immune system may allow the body to better fight cancer on its own.
New theories about how neural activity and visual stimuli sculpt the developing visual system.
A newly discovered protein in nerve cells holds enzymes poised for action next to their receptor.
Interferon cures only 20 percent of patients infected with hepatitis C virus. HHMI researchers may know the reason why.
Complex mathematical analysis reveals how potassium is allowed to travel across the cell membrane.
Sons conceived with the aid of a popular in vitro fertilization technique carry same genetic mutations that rendered their fathers infertile.
Molecular studies of a family of genes are pruning branches from the old evolutionary tree.
Genetic studies confirm that one gene mutation plays a major role in inherited deafness; the importance of another genetic mutation is called into question.
HHMI researchers discover a gene responsible for triggering embryonic cells in the inner ear to develop into sound- and motion-sensing hair cells.
HHMI researchers have found a protein whose activity controls the shape of a developing organ.
HHMI researchers have discovered a molecule that resembles a component of snake toxins, but has a dramatically different effect on the nervous system.
Research to improve vaccines for infectious diseases must move forward. At the same time, according to HHMI investigator Barry Bloom, scientists should be perfecting vaccines that tackle pathogens associated with other diseases, such as cancer and heart disease.
Nitric oxide prevents programmed cell death by handcuffing the molecular executioner.
Studies of a molecule that causes severe weight loss in cancer patients may yield new drugs to treat obesity.
Two HHMI labs discover a new molecular road sign that directs axons to their proper destination in the central nervous system.
HHMI researchers find that the mahogany protein suppresses obesity and plays a role in the immune system.
With odorant receptor genes from Drosophila in hand, researchers hope to learn how odors influence behavior.
How does the nose discriminate between different odors?
HHMI researchers have developed a versatile method for improving binding properties of potential drugs.
HHMI researchers have identified a gene that influences formation of the chambers of the heart.
Mouse geneticists get a boost with the release of an encyclopedia containing more than 360,000 genetic sequences.
By studying flies that have mutations similar to some cancer patients, HHMI researchers have found a new type of tumor suppressor gene.
Dopamine transporter knockout mice developed by HHMI investigator Marc Caron and colleagues have provided a wealth of information about the molecular nature of some behavioral disorders.
A human cell surface protein that maintains the structural integrity of tissues is also the portal of entry for bacteria and viruses.
HHMI investigators have produced an image of the active form of the HIV enzyme reverse transcriptase. This work may clarify how mutations render HIV resistant to antiviral drugs.
A team of scientists from the Howard Hughes Medical Institute at the University of Chicago has found that a ubiquitous protein may explain how relatively sudden changes in body shape occur in a species.
Un equipo de científicos del Instituto Médico Howard Hughes en la Universidad de Chicago ha encontrado que una ubicua proteína puede explicar cómo se llevan a cabo los cambios relativamente repentinos en la forma del cuerpo de una especie.
The most common genetic cause of infant mortality happens because cells cannot properly process messenger RNA. The search for drugs to correct this defect is underway.
HHMI investigators have found a cellular target of survival signals that can override programmed cell death.
Genetic studies have uncovered a host of new genes involved in the formation of spores in yeast. The studies may illuminate germ cell production in vertebrates.
HHMI researcher Leonard Zon leads a team that has cloned a zebrafish anemia gene, producing one of the first fish models of a human disease. The achievement opens a new avenue for studying the genetics of human diseases.
HHMI researchers show that ribozymes and enzymes are ready to perform their biological function as soon as they are produced.
The tumor suppressor p16 normally holds the growth-promoting molecule Cdk6 in check. New structural insights may explain how Cdk6 slips free from p16, promoting cancer development.
HHMI researchers produce the first glimpses of the molecular machinery that propels neurotransmitters into the synapse.
HHMI investigators have found another molecular landmark that points growing neurons to their proper destination in the brain or spinal cord.
Researchers report the first hard evidence that most cases of colon cancer arise when mutations in a genetic "master brake" help to switch on a well-known cancer-promoting gene.
Researchers used to identify important developmental genes one at a time. Now, a technique developed in Drosophila is taking wing, and hundreds of novel genes have been found.
Researchers find that a drug used to treat adult-onset diabetes may promote the formation of colorectal tumors.
The human immune system can recognize and destroy thousands of invaders. Did this diversity come about accidentally when a mobile piece of DNA inserted itself into the mammalian genome more than 450 million years ago?
Researchers discover new details about how cells monitor the signals that stimulate proliferation or shut down cell growth. Such signals can turn a normal cell into one that grows uncontrollably, the first step in the development of cancer.
Salt is poison for people with high blood pressure. Genetic studies are beginning to clarify who is at risk and why.
Scientists Determine Structure of HIV-1 Protein that Grasps Human Cells.
Researchers have identified a faulty conduit into nerve cells that causes them to fire uncontrollably, triggering the brief seizures that characterize some forms of epilepsy.
eCircadian clocks maintain the sleep-wake cycle for a 24-hour day in a variety of organisms. Two HHMI researchers and their colleagues have discovered more of the clock's molecular components.
Hughes investigators have discovered a family of packemaker ion channels that power the heart and the brain
Knockout mice point the way to a new theory of how a ubiquitous protein may promote heart disease.
HHMI researchers have discovered a genetic mutation that damages heart muscle so that it dilates to the point where the heart can no longer pump blood.
Familial hypertrophic cardiomyopathy is the most common underlying cause of sudden cardiac death in young athletes. New research suggests the disorder may be more widespread than previously thought.
Hughes investigators have discovered that a compound produced by the ocean-dwelling sponge Haliclona shuts down the ubiquitous cellular motor proteins that power cell division and a variety of other processes.
For nearly 50 years, scientists have wondered what a potassium channel looks like. Now, an HHMI research team at The Rockefeller University unveils the channel's surprising architecture.
Spontaneous neural activity in the developing brain is necessary to help organize the detailed connections that exist in the visual system.
Recent research may help clarify whether type 2 diabetes is caused by errant genes or faulty biology.
How does a virus inactivate a tumor suppressor protein? Hughes researchers have crystallized one key tumor suppressor in the act of being handcuffed by a fragment of the human papilloma virus.
The discovery of two nerve cell hormones and their receptors may help explain how the brain senses hunger signals and responds by increasing appetite.
Hughes investigators have identified two of the Ebola virus's main targets in the human body. They are now working on a vaccine against Ebola virus that primes the immune system to ward off the virus.
Three teams of Hughes researchers are closer to understanding how axons, the long projections of nerve cells, grow toward and across an organism's midline to wire up both sides of the body.
HHMI researchers have determined the three-dimensional structure of a protein-RNA complex that shepherds the production of infectious copies of HIV. The structure is a promising target for new antiviral drugs. Article published in the January 16, 1998 issue of Science.
Researchers suspect that a combination of genes and environment determine one's susceptibility to allergic conditions. Hughes researchers and colleagues at Washington University have identified a mutant protein that may cause hypersensitivity to common allergens.
HHMI physician postdoctoral fellow Michael Yaffe and his colleagues have demonstrated a new mechanism that governs chaperone activity and affects the vitality of cells.
Benjamin Doranz, an HHMI predoctoral fellow, is helping to devise a gene therapy technique that could destroy the hidden, latent reservoir of HIV-infected cells that escape drug therapy. Article published in the November 21 issue of Science.
HHMI international scholar B. Brett Finlay hopes to learn exactly how E. coli adheres to target cells - and to improve the treatment of diarrheal diseases.
Research by an undergraduate at the University of South Carolina could lead to a better understanding of the genetic relationship among dinosaurs, birds and alligators.
Lisa Goodrich and HHMI investigator Matthew Scott are probing how genes that guide normal development can sometimes go awry and lead to cancer.
Two Hughes investigators, working in parallel, advance our understanding of AIDS by discovering the way HIV, the virus that causes AIDS, penetrates a cell.
Hughes researcher Yuet Wai Kan and his colleagues have designed a prenatal blood test to diagnose fetuses at risk for developing sickle cell anemia and thalassemias.
Hyock Joo Kwon has helped to determine the structure of the active site of bacteriophage lambda integrase, a well-studied protein that had proven difficult to visualize.
Stephen Blacklow, a former HHMI postdoctoral fellow, has made a discovery that may explain why some people have high cholesterol levels
Jeffrey M. Friedman and colleagues report that the weight-reducing effects of the hormone leptin result from interaction with a receptor in the brain's hypothalamus and other tissues.
Graeme Bell and other researchers have found a gene that may make people susceptible to type II diabetes.
A team of HHMI scientists has peered deep inside HIV-1 for a closer view of the fragile shell that envelops the virus' genetic material.
Dan Littman and fellow researchers have found a receptor for HIV that appears to play a key role in the transmission of the virus between individuals.
Michael Naski has helped to identify a genetic mutation that can cause bones to stop growing, leading to a form of dwarfism.
HHMI researchers have learned that basal cell carcinoma is caused by a defect in a gene that restrains cell growth.
HHMI scientists at the University of Texas Southwestern Medical Center are blocking the enzyme telomerase in a new strategy to prevent cancer cells from dividing.
Don Ganem's decision to search for a viral cause for Kaposi's sarcoma was considered risky by many molecular biologists.
Sharon Long's studies of signal transduction pathways in plants could yield insights into cancer and other diseases in humans.
Hughes researchers have developed a technique that may speed the identification of more tumor suppressor genes.
International research scholar Alec Jeffeys believes that radiation leaked from Chernobyl more than a decade ago may only now be manifesting its diastrous legacy.
Students at Texas Tech University are co-authors on a Nature paper showing a high rate of genetic change in rodents living near the Chernobyl reactor.
HHMI investigator Michael J. Welsh's research team has found that the airways of CF patients lack a natural substance that kills bacteria.
Hughes investigator Ronald D. Vale's research provides fresh insight into the structure and operation of the motor proteins that convert chemical energy in the cell into physical movement.
Experiments by Marc Caron and colleagues reveal the importance of the dopamine transporter in conditions such as addiction, schizophrenia and Parkinson's disease.
The discovery of a common genetic circuit for limb formation in arthropods is not only important for developmental biology, but also holds promise as an important new window to the past.
Genes and partial gene sequences are being found at a rate far faster than anyone can decipher their function. Two groups of Hughes researchers have been attacking that bottleneck with automated programs designed to shed light on the function of newly found genes and the expression patterns of known genes.
Peter S. Kim, an HHMI investigator at the Whitehead Institute for Biomedical Research, believes that the coiled-coil structure of a protein may provide HIV with the spike it needs to infect cells.
HHMI investigator Kevin P. Campbell, HHMI associate Franck Duclos and University of Iowa College of Medicine M.D./Ph.D. student Leland Lim have identified a new form of muscular dystrophy and developed a screening test to detect carriers of the disease.
Daniel E. Goldberg and colleagues have discovered how the malaria parasite is able to safely sidestep a poison in hemoglobin, its main food source.
HHMI Investigator Ronald M. Evans has found a new hormone that triggers cells to become fat cells.