A new technique transforms biological tissue into an optically transparent sample that retains its original structure and molecular information.
Stephen Elledge recognized for research on DNA repair.
New research reveals how a localized source of a signaling molecule directs a dividing stem cell to produce two different cells—one identical to its parent, the other a more specialized cell type—and aligns those cells.
Researchers have found that temperatures on the surface of the tropical South Atlantic Ocean in July can predict the severity of malaria outbreaks in northwestern India that begin to peak four months later.
Scientists have a new view of the cellular machinery that assembles directly on DNA and readies it for transcription into RNA, the first step in protein production.
Three HHMI scientists are among 11 honored for excellence in research aimed at curing intractable diseases and extending human life.
Scientists have discovered that periodic ring-shaped actin arrangements encircle the long axonal fibers of nerve cells, in contrast to the linear meshworks that typically give cells their shapes.
HHMI scientists discover how a single molecule in a living cell can respond differently to different strengths of an external signal.
A new analysis suggests that the regulatory protein MeCP2 works with the modified nucleotide 5hmC to facilitate gene activation in the brain.
Scientists have discovered the molecular pathway responsible for detecting loose bits of DNA outside a cell’s nucleus and setting off an immune reaction.
Rather than scrutinizing hours of video, scientists can quickly teach the software how to recognize key behaviors.
AAAS recognizes Ulrike Heberlein and Nelson Spruston for meritorious efforts to advance science.
A new DNA sequencing technique has enabled researchers to map for the first time the influential chemical modifications known as methylation marks throughout the genome of a pathogenic bacterium.
eLife makes first collection of research articles available online.
Robert Lefkowitz de HHMI comparte el premio con Brian Kobilka por estudios sobre los receptores acoplados a proteínas G.
Only a few animals, such as songbirds, whales, and dolphins, are known to be vocal learners, modifying the sequence or pitch of their sounds based on what they hear from other members of their species. New evidence suggests mice can be added to that list.
HHMI's Robert Lefkowitz shares prize with Brian Kobilka for research on G-protein coupled receptors.
HHMI and the University of KwaZulu-Natal open new research institute in Durban, South Africa.
In experiments with rats, researchers found that the rejection of an old belief correlates with abrupt changes in activity in a region of the brain involved in cognitive functions such as reward anticipation and decision-making.
HHMI selects 13 of the world’s leading basic science researchers to receive Senior International Research Scholar (SIRS) awards. The awards support outstanding biomedical scientists working outside the United States who have made significant contributions to fundamental research in the biological sciences.
HHMI investigator Ronald D. Vale of UCSF will share the 2012 Albert Lasker Basic Medical Research Award.
Thousands of genes in organs throughout the body show predictable daily fluctuations. New research reveals complexity in how those genes' cycles of activity are controlled.
A discovery of how ethylene triggers changes in gene activity could lead to new ways to stop or slow ripening.
The vaccinia virus increases the size of its genome when it confronts the immune system, thereby increasing the odds of a random mutation that will improve its survival.
By investigating the cause of a fatal snake disease, scientists have found a virus that links two known virus families that can cause fatal hemorrhagic fevers in humans.
Mutations in four different DNA damage repair genes have been linked to chronic kidney disease.
Scientists have catalogued and compared the hundreds of types of bacteria that associate with the roots of the model plant Arabidopsis under various conditions.
Nurse's lecture on Great Ideas of Biology will take place at HHMIs Janelia Farm Research Campus on July 31.
With a newly discovered component of an adaptive bacterial immune system, scientists have identified a targeted method of slicing DNA that they say can be easily customized for a variety of applications.
Short strands of piwi-interacting RNA may detect foreign invaders by determining whether a gene has ever been turned on in an organism's past.
Quake is being recognized for his work in drug discovery, genome analysis and personalized medicine.
A new imaging technology developed at Janelia lets users track each cell in an embryo as it takes shape over hours or days.
Thirty years after their discovery, scientists have the first picture of a Wnt protein, a member of a protein family that includes some of the most important regulators of growth and development.
HHMI scientists have determined the three-dimensional structure of two proteins that help keep the bodys clocks in sync.
The three scientists are recognized for elucidating basic neuronal mechanisms underlying perception and decision.
Arthur Horwich and Franz-Ulrich Hartl honored for contributions to the understanding of the molecular mechanism of protein folding.
Using genetic programming, researchers have identified a specific type of cell in the outer layers of the brain that is crucial for Prozac's action.
Researchers lay out evidence for how an unusually efficient enzyme evolved from non-catalytic ancestor proteins.
In the region of the brain that controls motor planning, a self-reinforcing loop of neuronal signaling helps establish connectivity during early development.
Researchers have uncovered the enzyme that transfers phosphate to milk proteins like casein, but also to proteins found in bones and teeth enamel.
Many of the most severe mutations identified in patients with autism affected proteins that work together in one large interconnected network.
As fish in different parts of the world adapted to live in fresh water, the same sites in the genome were changed time and again.
HHMI researchers Thomas M. Jessell and Michael Rosbash honored for significant contributions to medical science.
HHMI seeks to appoint up to 30 new HHMI investigators in 2013. Applications open on March 15, 2012.
Long, ropy fibers were long thought to be the causes of these diseases including Alzheimer's and Parkinsons, but research over the past decade has revealed that fibers arent amyloid proteins' most toxic form.
In a mouse model of Alzheimer’s disease, an overactive enzyme causes memory problems by shutting off genes related to neuronal communication.
Defectos en el gen que codifica para la proteína más grande del cuerpo humano son responsables de más casos de la enfermedad que los causados por todas las otras mutaciones conocidas.
Defects in the gene that encodes the human body’s largest protein are responsible for more cases of dilated cardiomyopathy than are caused by all other known mutations associated with the heart disorder.
HHMI researcher and colleagues design and develop drug that prolongs survival in men with advanced prostate cancer.
Investigador del HHMI y sus colegas diseñan y desarrollan una droga que prolonga la supervivencia de hombres con cáncer de próstata avanzado.
HHMI investigator Brian Druker honored for role in developing new cancer drug.
Meet the 2012 International Early Career Scientists
Top biomedical scientists from 12 countries will receive an important boost at a critical time in their careers from HHMI’s inaugural International Early Career Scientist awards.
A breakdown of cellular junk may explain how exercise fends off metabolic disorders and protects against other diseases.
Researchers have discovered a molecular master switch that triggers the genetic overhaul plants need to fight off pathogens.
The gene mutation that causes retinoblastoma changes the way cells turn on and off many other genes.
Researchers have discovered how plants regulate the development of the pores through which critical exchanges of water and carbon dioxide occur.
By resurrecting the ancient forms of a molecular machine, scientists have learned how simple evolutionary processes can produce the complex assemblies of molecules that allow modern cells to function.
New research shows that fluoride has dramatic effects on bacteria inside the mouth.
Scientists have pinpointed the gene responsible for a disease that causes seizures in infancy and sudden, uncontrollable movements in adolescence and early adulthood.
Studies of fragile X syndrome and tuberous sclerosis show that for brain cells to function normally, neural synapses must produce just the right amount of protein.
By activating regions of the brain linked to food-related pleasure, scientists are learning how the brain mediates the link between food preferences and hunger.
Blood vessels in the lungs produce signals that activate the regeneration of alveoli—the tiny cavities through which blood takes in oxygen and releases carbon dioxide.
The fruit-fly protein Zelda helps govern the developmental handoff from mother's influence to an animal's own genome.
Fruit flies integrate smell and visual information to fine-tune flying behavior.
Seven HHMI investigators are among the 65 new members announced today.
New HHMI research shows that reactivating fetal hemoglobin production in adult mice effectively reverses sickle cell disease.
Nueva investigación del HHMI muestra que la reactivación de la producción de hemoglobina fetal en ratones adultos revierte eficientemente la enfermedad de células falciformes.
At least 100 trillion bacteria live in the mammalian gut. How can we carry all those organisms and not get sick?
HHMI scientists have identified a cellular pathway that may be key to sparking growth of pancreatic beta cells in mice and humans.
Neurobiologist Leslie Vosshall will discuss why mosquitoes bite some people and not others at a lecture on November 9. The event is free and open to the public.
New research pinpoints a biological barrier that has thus far slowed progress in creating disease-specific stem cell lines using a technique known as nuclear transfer.
Dietary folic acid helps prevent a subset of neurological birth defects in humans. Now, researchers have found that certain genetic mutations in mice that mimic these birth defects do not respond to a diet enriched with folic acid.
In the last 18 months, Janelia Farm has recruited two group leaders, four fellows and four junior fellows.
In one region of the human brain, new cells are generated only until 18 months of age.
Most of the neurons in the VNO, a sensory organ long assumed to be primarily devoted to pheromone detection, are dedicated to the detection of animals from other species.
A new study in fruit flies suggests that DEET confuses insects by jamming their odor receptors.
New studies highlight promising vaccine strategies to prevent malaria parasites from causing illness and death.
Horwich and Franz-Ulrich Hartl share the 2011 Albert Lasker Basic Medical Research Award for key discoveries that elucidate steps in protein folding.
Scientists have identified a genetic regulator that controls the reshuffling of gene segments in immune cells.
Beachy is being honored for his work on Hedgehog, a key molecule in development.
HHMI researchers have developed a potential TB vaccine that completely eliminates tuberculosis bacteria from infected tissues in some mice.
Distinct areas of the brain process sweet, bitter, salty, and umami tastes.
Designer ion channels that can turn neurons on or off will help researchers understand the connection between behavior and neural circuitry.
The first definitive proof of a weak spot in the parasite's apicoplasts—organelles with ancient plant origins—offers hope for drugs and vaccines against malaria.
New research has classified vertebrate evolution in relation to periods of evolution marked by changes in specific kinds of genes.
Protective chemicals known as interferons may identify themselves by how tightly they grip their receptor at various attachment points.
An HHMI-funded researcher has used online gene expression profiles to match old drugs with diseases in need of treatments.
Next-generation sequencing and stem cell technology have helped scientists identify a mutation that causes retinitis pigmentosa.
Understanding of antibody may help scientists design a longer-lasting vaccine against the influenza virus.
A test that detects a cancer-causing fusion gene in men’s urine could help reduce the number of prostate biopsies performed each year.
Two studies reveal genetic mutations often present in the most common form of head and neck cancer, offering a picture of how the cancer develops and how therapeutics could treat it.
A genetic comparison of E. coli strains, including the one responsible for the recent outbreak of infections in Europe, underscores how rapidly evolving bacterial genomes can lead to the emergence of new pathogens.
Altering the balance of excitatory and inhibitory inputs in the brains of mice disrupts the animals' social interactions.
The neurological problems caused by Fragile X syndrome may be due to excess synthesis of certain proteins.
An immune defense protein uses prion-like qualities to fend off viruses.
Small bits of RNA can cause a connective tissue cell from human skin to transform into a nerve cell.
A new understanding of a gene that is commonly mutated in people with myeloid leukemia could help lead to new treatments.
Scientists have used a gene therapy tool that acts like intelligent molecular scissors to correct the key gene defect in mice with hemophilia B.