HHMI researchers have found that mice lacking a gene that helps turn off receptors to morphine can tolerate pain longer using lower doses of the drug.
Investigadores del HHMI han descubierto que ratones que carecen de un gen que ayuda a desactivar los receptores para la morfina, pueden tolerar más dolor utilizando dosis menores de la droga.
HHMI researchers have found that an enzyme that snips apart proteins that form brain-clogging plaques in people with Alzheimer's disease also appears to regulate enzymes that fold new proteins into their working forms in healthy cells.
Investigadores del HHMI han encontrado que una enzima que cliva las proteínas que forman las placas cerebrales obstructivas presentes en personas con la enfermedad de Alzheimer también parece regular enzimas que pliegan nuevas proteínas en su forma activa en células sanas.
The 3D structure of a viral harpoon reveals that measles, HIV and Ebola viruses may share common ancestor.
HHMI researchers have shown how the world's smallest moving machines generate the motion needed to transport their chemical cargo.
Investigadores del HHMI han mostrado cómo las maquinarias motoras más pequeñas del mundo generan el movimiento necesario para transportar su carga química.
A team of HHMI researchers and their colleagues have identified a genetic mutation that increases susceptibility to massive bacterial infections and septic shock.
Two strains of mice provide new models in which to evaluate therapies for this tumor-producing hereditary disease of the peripheral nerves.
Pequeños retazos de ADN enterrados en el genoma humano, revelan que una familia antigua de virus se estableció permanentemente en nuestros ancestros simios hace unos 30 millones de años. Este ADN viral se asemeja al gen que el HIV utiliza durante su ciclo reproductivo dentro de las células humanas.
Dos cepas de ratones proveen nuevos modelos en los cuales evaluar terapias para esta enfermedad hereditaria de los nervios periféricos, productora de tumores.
Un estudio en ratones adultos mostró que el ejercicio regular y voluntario permite, de alguna manera, que células nerviosas nuevas crezcan en la parte del cerebro encargada de la memoria a largo plazo. Los ratones que hacían ejercicio presentaron una mejor memoria que un grupo de ratones holgazanes.
Investigadores del HHMI han encontrado una molécula que activa la formación precoz de los entramados mortales de proteínas que dañan y matan a las células cerebrales.
HHMI researchers have found a molecule that triggers early formatin of the deadly snarls of protein that damage and kill brain cells.
An arduous search of the human Y chromosome for genetic causes of male infertility has found a smoking gun—mutations in a single gene that prevents sperm from developing. This discovery by HHMI investigator David Page could eventually lead to male contraceptives and treatments for male infertility.
HHMI researchers identify more molecules involved in a common inherited form of mental retardation.
Tras una ardua búsqueda en el cromosoma Y para encontrar las causas de la infertilidad masculina, se ha develado que mutaciones en un único gen pueden impedir el desarrollo de los espermatozoides.
Investigadores del HHMI han identificado más moléculas involucradas en una forma de retardo mental que comúnmente se hereda.
hedding Light on Circadian RhythmsTwo teams of HHMI researchers and their collaborators have found what may be the missing molecular link between sunlight and the circadian clock.
In C. elegans, sexual fate—whether to remain female or become male—depends on a unique mechanism for counting X chromosomes.
Tiny snippets of DNA, buried in the human genome, reveal that an ancient family of viruses took up permanent residence in our simian ancestors some 30 million years ago. This viral DNA resembles a gene that HIV uses during its reproductive cycle within human cells.
A study in adult mice has shown that regular voluntary exercise somehow allows new nerve cells to grow in the part of the brain that manages long-term memories. The exercising mice had better memories than a group of couch potato mice.
HHMI researchers at Baylor College of Medicine have identified a protein that works closely with BRCA1 to initiate the repair of damaged DNA. They say that mutations in the gene that produces this BRCA1 trigger protein may be responsible for more instances of breast cancer than BRCA1 mutation.
Investigadores del Instituto Médico Howard Hughes (HHMI), en el Colegio de Medicina Baylor, han identificado una proteína que trabaja junto con BRCA1 para iniciar la reparación del ADN dañado. Ellos dicen que mutaciones en el gen que produce esta proteína activadora de BRCA1 pueden ser las responsables de más casos de cáncer que los producidos por mutaciones en BRCA1.
More than one in three people on the planet have tuberculosis (TB). HHMI investigators have pinpointed a weak spot in the bacterium that causes TB.
4 de noviembre de 1999 — Más de un tercio de la población mundial tiene tuberculosis (TB). Investigadores del HHMI han detectado un punto débil en la bacteria que causa la tuberculosis.
HHMI researchers are moving closer to understanding the entire developmental program that underlies motor neuron differentiation.
The X and Y chromosomes may have arisen from an identical pair of standard chromosomes approximately 240 to 320 million years ago.
HHMI researchers have illuminated a crucial step in the immune system's response to infection by using live cell imaging to follow the movement of immune system cells that have been genetically manipulated to produce a fluorescent jellyfish protein.
Nuevas evidencias muestran que el origen de los cromosomas sexuales es más antiguo de lo que se pensaba. Los cromosomas X e Y se podrían haber originado a partir de un par idéntico de cromosomas hace aproximadamente entre 240 a 320 millones de años.
HHMI researchers discover that growing neurons must reach a specific intermediate destination by a certain time or risk not receiving critical life-sustaining chemical signals from specialized spinal cord tissue.
Investigadores del HHMI descubrieron que las neuronas en crecimiento tienen un determinado tiempo para alcanzar un destino específico o corren el riesgo de no recibir las seóales químicas, provenientes de tejidos especializados del cord en espinal, que requieren para su supervivencia.
The Nobel Assembly at the Karolinska Institute has awarded the 1999 Nobel Prize in Physiology or Medicine to Günter Blobel.
Günter Blobel gana el Premio Nobel El Comité del Premio Nobel, en el Instituto Karolinska, ha galardonado a Günter Blobel con el Premio Nobel de Fisiología o Medicina 1999.
HHMI researchers have determined the three-dimensional structure of invasin, a protein that allows a close relative of the bubonic plague bacterium to infect intestinal cells and cause food poisoning.
By studying five generations of a Maine family, HHMI researchers have learned how an inherited leukemia develops.
HHMI researchers develop a new class of molecules that can prevent HIV infection of human cells.
A 14-year search for the genetic mutations that trigger a neurodegenerative disease has ended.
A unique hemoglobin is key to a parasitic worm's ability to survive in a world containing oxygen.
New antiviral compounds may prevent HIV infection of cells by disrupting the protein gp41.
A gene crucial to C. elegans mating behavior resembles a gene involved in polycystic kidney disease.
HHMI investigators say that stem cells may prove to be better than viruses for delivering corrective genes to tissues throughout the body.
HHMI investigators have found a gene that determines whether roundworms prefer to eat alone or in a group. Further studies may give a glimpse at the genetic origins of social behavior.
HHMI researchers are making fundamental advances in understanding how genes control the shape and spatial orientation of organs.
Scientists have uncovered a critical mechanism by which light resets the biological clock in flies. This finding could lead to new treatments for jet lag and improved therapies for mood and sleep disorders.
HHMI researchers have used a fragment of HIV to deliver proteins into the cells of living mice.
Two related proteins that act as brakes for a variety of cellular growth processes appear to play a critical role in ensuring that both blood cells and immune system cells are neither overactive nor overabundant.
HHMI researchers believe their technique can be used to determine the function of all of the fruit fly's genes.
HHMI researchers have found the first hereditary human sleep disorder that is caused by a single gene. The disorder is passed from generation to generation in the same simple pattern characteristic of traits such as eye color.
A team of biologists has determined the three-dimensional structure of an enzyme that allows certain bacteria to resist the killing effects of the antibiotic gentamicin. The structure is also shared by a number of proteins involved in basic biological processes, including circadian rhythms and gene regulation.
A genetic mutation common in the most severe forms of muscular dystrophy also predisposes to heart damage.
Two genes that generate the immune system's remarkable diversity are controlled by the same small piece of DNA.
Mice born without a gene that regulates appetite exhibit unexpected attacks of narcolepsy.
A two-tiered boost to the immune system may allow the body to better fight cancer on its own.
New theories about how neural activity and visual stimuli sculpt the developing visual system.
A newly discovered protein in nerve cells holds enzymes poised for action next to their receptor.
Interferon cures only 20 percent of patients infected with hepatitis C virus. HHMI researchers may know the reason why.
Complex mathematical analysis reveals how potassium is allowed to travel across the cell membrane.
Sons conceived with the aid of a popular in vitro fertilization technique carry same genetic mutations that rendered their fathers infertile.
Molecular studies of a family of genes are pruning branches from the old evolutionary tree.
Genetic studies confirm that one gene mutation plays a major role in inherited deafness; the importance of another genetic mutation is called into question.
HHMI researchers discover a gene responsible for triggering embryonic cells in the inner ear to develop into sound- and motion-sensing hair cells.
HHMI researchers have found a protein whose activity controls the shape of a developing organ.
HHMI researchers have discovered a molecule that resembles a component of snake toxins, but has a dramatically different effect on the nervous system.
Research to improve vaccines for infectious diseases must move forward. At the same time, according to HHMI investigator Barry Bloom, scientists should be perfecting vaccines that tackle pathogens associated with other diseases, such as cancer and heart disease.
Nitric oxide prevents programmed cell death by handcuffing the molecular executioner.
Studies of a molecule that causes severe weight loss in cancer patients may yield new drugs to treat obesity.
Two HHMI labs discover a new molecular road sign that directs axons to their proper destination in the central nervous system.
HHMI researchers find that the mahogany protein suppresses obesity and plays a role in the immune system.
With odorant receptor genes from Drosophila in hand, researchers hope to learn how odors influence behavior.
How does the nose discriminate between different odors?
HHMI researchers have developed a versatile method for improving binding properties of potential drugs.
HHMI researchers have identified a gene that influences formation of the chambers of the heart.
Mouse geneticists get a boost with the release of an encyclopedia containing more than 360,000 genetic sequences.
By studying flies that have mutations similar to some cancer patients, HHMI researchers have found a new type of tumor suppressor gene.
Dopamine transporter knockout mice developed by HHMI investigator Marc Caron and colleagues have provided a wealth of information about the molecular nature of some behavioral disorders.
By tricking HIV into showing more of itself than usual, researchers have produced antibodies that neutralize many infective strains of the virus.