For some developmental genes, one allele must stay silent, otherwise debilitating syndromes and cancers can arise. HHMI Investigator Yi Zhang and his colleagues have uncovered a new imprinting mechanism cells use to keep these genes quiet in mice.
Scientists at HHMI’s Janelia Research Campus created comprehensive brain maps linking different groups of neurons to specific behaviors, using a machine-learning program that annotated more than 225 days of videos of flies – a feat that would have taken humans some 3,800 years.
Janelia Research Campus scientists have uncovered new clues about how fruit flies keep track of where they are in the world. Understanding the neural basis of navigation in flies may reveal how humans accomplish similar feats.
In studies with mice, Janelia researchers discovered that to maintain certain short-term memories, the brain’s cortex relies on connections with the thalamus.
Hypoxia reverses brain damage caused by mitochondrial dysfunction, HHMI team finds. The approach might one day point to new therapies for people with Leigh syndrome and other mitochondrial disorders.
New HHMI research reveals that adding or deleting chromosomes in cells and animals prompts a wide variety of outcomes. The work could help scientists better understand chromosomal abnormalities in humans.
HHMI Investigator Huda Zoghbi is one of seven scientists honored with prestigious awards from Canada's Gairdner Foundation.
New research adds to growing evidence that Parkinson's disease may arise in part from neurons’ failure to recycle the materials used to package and transport neurotransmitters.
HHMI scientists develop a much-needed genetic resource that is aiding development of wheat plants with improved traits.
HHMI investigators Stephen Elledge, Roel Nusse and Huda Zoghbi are among the scientists honored for transformative advances toward understanding living systems and extending human life.
HHMI researchers identify the mechanisms that pathogenic bacteria use to waterlog the space between plant cells in the leaves, allowing the bacteria to reproduce and spread infection.
Janelia scientists have developed the first adaptive light-sheet microscope — an instrument that continuously analyzes and adapts to dynamic changes in a specimen and thereby improves spatial resolution.
HHMI researchers find that a gene that blocks the differentiation of pigment-producing cells in the skin of the African striped mouse helps in generating the mouse’s characteristic light-colored stripes.
The first unbiased genetic screen for sleep defects in mice yields two interesting mutants, Sleepy, which sleeps excessively, and Dreamless, which lacks rapid eye movement sleep.
Janelia scientists are learning how animals adjust their physical exertion as changes in the environment or their own bodies alter how efficiently they move.
A new viral vector will help scientists understand large-scale neural networks.
HHMI researchers have learned to program T cells as if they were "microscopic robots" -- to sense inputs and to respond.
Lasker Award honors research showing how cells from humans and most animals sense and adapt to changes in oxygen availability.
Janelia scientists have identified a gene that causes male Drosophila to produce different courtship songs.
Using novel computational and biochemical approaches, HHMI scientists have designed and built from scratch 10 large protein icosahedra that are similar to viral capsids that carry viral DNA.
International research team unveils new data describing the interaction between genetic and epigenetic variation in Arabidopsis thaliana.
Janelia scientists find that a molecule best known for its role in pain perception also plays an important role in regulating body weight.
HHMI scientists have pioneered the use of genome editing to trace lineage in living systems.
Researchers have discovered that fat tissue is a previously unrecognized reservoir of trypanosomes, the parasites that cause sleeping sickness.
HHMI scientists have designed a potential cancer therapy that uses a unique strategy to block a molecule that drives the growth of cancer.
New experiments help explain how the brain speeds up or slows down movement.
Analyses of ancient DNA from prehistoric humans paint a picture of dramatic population change in Europe from 45,000 to 7,000 years ago.
On May 18, Michael Kennedy will deliver a talk, “The Power of Community: Improving STEM Futures for Urban Youth” at 7:00 p.m. at Janelia Research Campus
New research from Janelia scientists suggests the brain is organized into modules that work together to maintain critical functions, even in the face of disturbances.
HHMI scientists have discovered a command center in the brain that controls how much insects eat and how quickly they consume their food.
HHMI, the Bill & Melinda Gates Foundation, the Wellcome Trust, and the Calouste Gulbenkian Foundation announce the International Research Scholars Program which aims to support up to 50 outstanding early career scientists worldwide.
In only the second time in history, all five Canada Gairdner International Awards are being given to one topic -- CRISPR-Cas technology.
HHMI scientists identify a region of the brain that is critical in translating danger signals detected by the nose into physiological responses.
Janelia announces the establishment of the neuronal cell biology program and recruitment of the first group leaders.
HHMI scientists identify a gene that might serve as a molecular link between mood and the circadian clock.
HHMI researchers have identified 27 genes in brain stem cells that are prone to a type of DNA damage called double-strand breaks.
New study suggests why mice with cystic fibrosis mutations can stave off bacterial infections in their lungs.
New experiments at HHMI's Janelia Research Campus show that activity in the cortex is critical for enacting a learned skill.
The MouseLight Project team at Janelia unveils a microscope and method for long-range tracing of neurons in the mouse brain.
New study suggests that graded changes in gene expression are an organizing principle for CA1 pyramidal cells in the hippocampus.
On February 24, HHMI investigator Bonnie Bassler will deliver a talk, “Tiny Conspiracies: Cell-to-Cell Communication in Bacteria,” at 7:00 p.m. at Janelia Research Campus.
Research uncovers new information about the biological processes that help ensure that two fly species don't interbreed.
HHMI researchers have discovered a molecular mechanism that enables plants to detect when they are in the shade of other plants and adapt by speeding up their growth.
Using an advanced imaging system with adaptive optics, Janelia scientists have uncovered new details about how the brain processes visual information.
New research examines why some children born with heart defects also have developmental disabilities.
Researchers learn more details about how CRISPR works in cells.
Scientists show they can control whether mice perceive a taste as bitter or sweet by activating two small areas of the brain.
HHMI investigators Karl Deisseroth and Helen Hobbs are among five scientists honored for transformative advances toward understanding living systems and extending human life.
HHMI scientists have identified a set of proteins that plays a surprisingly broad role in guiding tissue formation in plant roots.
Within less than a second, the new IsoView microscope produces images of entire organisms, such as a zebrafish or fruit fly embryo, with enough resolution in all three dimensions that each cell appears as a distinct structure.
HHMI's Paul Modrich shares 2015 Nobel Prize in Chemistry with Tomas Lindahl and Aziz Sancar for studies of DNA repair.
New research indicates individual human neurons may harbor up to 1,000 genetic mutations.
HHMI Investigator Stephen Elledge of Brigham and Women's Hospital shares the 2015 Albert Lasker Basic Medical Research Award with Evelyn Witkin of Rutgers University.
New imaging methods dramatically improve the spatial resolution provided by structured illumination microscopy, one of the best imaging techniques for seeing inside living cells.
HHMI scientists have discovered how the most common genetic defect in amyotrophic lateral sclerosis kills nerve cells.
HHMI researchers solve a longstanding mystery about the origin of new cells in the liver.
A lipid molecule called EET helps blood-forming stem cells replenish the immune system.
New research begins to explain how plants separate microbes they like from those they don't like.
HHMI scientists have profiled key features of the genetic material inside three types of brain cells and found vast differences in the patterns of chemical modifications that affect how the genes in each type of neuron are regulated.
New studies provide the first genetic evidence that humans interbred with Neanderthals in Europe.
New technology developed by HHMI researchers makes it possible to test for current and past infections with any known human virus by analyzing a single drop of blood.
Nueva tecnología desarrollada por investigadores del HHMI hace que se pueda utilizar una gota de sangre de una persona para analizar infecciones presentes y pasadas con cualquier virus humano conocido.
New research hints at strategies fruit flies use to keep track of where they are going, even when it's dark.
Studying fruit fly larvae, Janelia scientists have mapped the entire neural circuit involved in combining vibration and pain sensations used in triggering an escape behavior.
Negative emotions associated with hunger can make it hard to maintain a diet and lose weight. Hunger-sensitive cells in the brain may help explain that struggle.
HHMI researchers develop a new single-cell imaging technique that reveals the copy numbers and locations of thousands of RNA molecules inside a cell.
HHMI researchers identify a rare genetic mutation that tamps down immune response to influenza.
HHMI scientists have designed a revolutionary "3D printer" for small molecules that could open the power of customized chemistry to many.
Scientist at Janelia Research Campus wins The Brain Prize for helping to develop a tool that advances our understanding of how the brain's networks process information.
A new way of thinking challenges standard notions about what a herpes vaccine should look like.
Scientists at Janelia Research Campus have identified a neural circuit that connects motor planning to movement.
A new tool developed at HHMI's Janelia Research Campus lets scientists permanently mark neurons that are active at a particular time.
New studies by HHMI scientists show how cells use sophisticated signaling mechanisms to control production of interferon.
HHMI researchers have identified a neural circuit in the subfornical organ that regulates thirst in mice.
When battling a chronic infection, killer T cells must take a break so they can continue to fight off infection.
Janelia researchers show that Hox proteins trigger gene activity through weak interactions at previously unrecognized DNA binding sites in the genome.
Scientists have determined new structures of an essential cellular recycling machine with near atomic-level detail. The structures, which show a protein called NSF alone and interacting with its target, a protein complex called SNARE that is formed when membranes fuse together.
HHMI scientists and their colleagues discover a new mechanism of protein synthesis.
Researchers at HHMI's Janelia Research Campus have used motion-capture technology to reveal new insight into the sophisticated information processing and acrobatic skills of dragonflies on the hunt.
HHMI investigator Jennifer Doudna is among six scientists honored for transformative advances toward understanding living systems and extending human life.
Lattice light sheet microscopy, a new imaging platform developed at Janelia, lets biologists see 3-D images of subcellular activity in real time.
Eric Betzig, director de grupo en Janelia, gana el Premio Nobel por el desarrollo de la microscopía de fluorescencia de super-resolución.
Janelia group leader Eric Betzig wins Nobel Prize for the development of super-resolved fluorescence microscopy.
Retracing the ancient battles between jumping genes and the defenses human cells deploy to keep them in check.
Janelia scientists are learning how the brain switches between random and strategic modes.
HHMI scientists have shown that previously unrecognized groups contributed to the genetic mix now present in most modern-day Europeans.
HHMI Investigator Sangeeta Bhatia is recognized for designing and commercializing miniaturized technologies with applications to improve human health.
HHMI Investigator Peter Walter of UCSF shares the 2014 Albert Lasker Basic Medical Research Award with Kazutoshi Mori of Kyoto University.
New research by HHMI scientists shows that the emotional memory of an experience is malleable.
Janelia scientists are learning how the brain makes sense of new places.
HHMI scientists have devised a technique to identify hard-to-find gene mutations that crop up in a fraction of the body's cells.
By studying dirty flies, Janelia scientists hope to learn how animals carry out sequences of movements that make up more complex behaviors.
Big data can mean big headaches for scientists. A new library of software tools from Janelia speeds analysis of data sets so large and complex they would take days or weeks to analyze on a single workstation — if a single workstation could do it at all.
Janelia researchers develop a new computational method that can essentially automate much of the time-consuming process of reconstructing an animal's developmental building plan cell by cell.
HHMI and GBMF announce the establishment of an Advanced Imaging Center at Janelia that will make leading-edge imaging technologies more widely available to the scientific community before the instruments are available commercially.
Every millisecond counts when a fruit fly is being hunted by a damselfly. Janelia scientists find that fruit flies can deploy two escape behaviors, depending on circumstances.
HHMI researchers find that a single-letter change in the genetic code is enough to generate blond hair in humans.
HHMI scientists develop new tool to silence neurons with an unprecedented level of control.
Janelia researchers speed up image-processing time and get sharper microscopy images by employing techniques used by astonomers and ophthalmologists.
John P. Donoghue, Director of the Institute for Brain Science at Brown University, will speak on April 30 at 7PM at Janelia.