Nearly 70 million people worldwide have glaucoma, an insidious group of diseases that damages the optic nerve and leads to vision loss and blindness. High intraocular pressure, which damages nerve cells in the eye, is one of the biggest known contributing factors in the development of glaucoma.
HHMI broadens its research support with the announcement of a new program to foster collaboration and innovation.
HHMI announces the names of scientists selected to pilot a new program devoted to supporting transformative, collaborative research.
Researchers have traced the sequence of metabolic events that kill E. coli bacteria when they are treated with the antibiotic gentamicin.
New images from HHMI scientists show the stunning dynamics of HIV reverse transcriptase zooming around on the very DNA it is building.
A tiny RNA switch may play a big role in the spread of prostate cancer.
Researchers have discovered three genetic factors that could help doctors identify people who are at the greatest risk for developing a brain aneurysm.
Al escudriñar los genomas de más de 10.000 personas, unos investigadores han descubierto tres factores genéticos que podrían ayudar a que los doctores identifiquen las personas que tienen el mayor riesgo de desarrollar una aneurisma cerebral.
Researchers have developed a method for systematically screening cancer cells to detect genes likely to suppress metastasis.
Researchers have identified the chief motor protein that hauls the building materials needed for learning to their destinations inside neurons.
A new technique factors a protein's flexibility into the drug design equation. It's paying off in a big way.
New technology makes it possible to study tissue samples locked away for decades.
Nueva tecnología hace posible el estudio de muestras de tejidos guardadas por décadas.
Seven HHMI investigators have been elected to the Institute of Medicine.
New studies show how the brain changes when mice learn to feel safe and secure in situations that would normally make them anxious.
Roger Tsien, Osamu Shimomura, and Martin Chalfie honored for the discovery and development of the green fluorescent protein, a ubiquitous research tool.
Roger Tsien, Osamu Shimomura and Martin Chalfie son galardonados por el descubrimiento y desarrollo de la proteína fluorescente verde, que es una herramienta general de investigación.
HHMI researchers devise prenatal blood test that accurately detects Down syndrome and two other serious chromosomal defects.
Investigadores del HHMI desarrollan un nuevo análisis de sangre prenatal que detecta con precisión el síndrome de Down y otros dos defectos cromosómicos serios.
Janelia hosted 14 undergraduate students who worked on research projects under the guidance of research scientists.
HHMI researchers have found microRNAs in animal species whose last common ancestors were present on Earth about 1 billion years ago.
Robert Tjian, a distinguished biochemist and long-time HHMI investigator at the University of California, Berkeley, will become HHMI's next president.
HHMI researchers have developed a new model of cystic fibrosis in pigs that more accurately mimics features of the disease.
Investigadores del HHMI han desarrollado un nuevo modelo de fibrosis quística en cerdos que imita de forma más precisa las características de la enfermedad que se observa en infantes humanos.
Researchers have identified a gene from a new family of ion channels that help to regulate smell and taste sensing, smooth muscle contraction, and fluid secretion in glands and airways.
A newly identified "hot line" connects a worm's nervous system to its immune system.
Investigadores han descubierto una “línea directa” de comunicación que le permite al sistema nervioso de un gusano llamar al sistema inmune para coordinar la respuesta a patógenos infecciosos.
Researchers have learned how Listeria crosses the placenta from mother to baby.
Researchers have devised clever techniques to visualize gene silencing in its natural context.
Professor Alison F. Richard is currently Vice-Chancellor of the University of Cambridge.
DeRisi receives the Heinz Award in Technology, the Economy and Employment.
A gene deletion caused mice to exhibit behavioral and brain changes common in people with Alzheimer's disease or dementia.
Researchers may be able to fight malaria by targeting human liver cells instead of parasites
Las drogas contra la malaria existentes atacan al parásito que causa la enfermedad, pero están perdiendo eficacia debido al aumento en la resistencia a drogas. Investigadores del Instituto Médico Howard Hughes informan que podrían ser capaces de combatir la malaria atacando células humanas hepáticas en lugar de a los parásitos.
A immunosuppressant drug may unexpectedly fight the parasite-caused disease.
Scientists have detected a multitude of broken, missing, and overactive genes in the most detailed genetic survey yet of any human tumor.
Mediante el examen genético más detallado de cualquier tumor humano que se haya realizado hasta el momento, científicos encuentran que en tumores pancreáticos y cerebrales una variedad de genes están rotos, hiperactivos o desaparecen.
Researchers have generated insulin-producing beta cells from adult pancreatic cells in living mice.
Investigadores del HHMI han transformado células pancreáticas adultas en células betas productoras de insulina en ratones vivos.
President Bush named HHMI investigator Robert J. Lefkowitz a recipient of the National Medal of Science for contributions to the biological sciences.
Graduates of the science and technology magnet program met over the summer to create engineering courses for high school students.
A statement regarding fraudulent activity involving checks that are purported to be from HHMI.
Thomas R. Cech, Nobel laureate and president of HHMI, will deliver a public talk on "RNA Enzymes and the Origins of Life" at the Janelia Farm Research Campus in Ashburn, VA.
Researchers have begun scouring cancer cells for potential sites of resistance against a new class of drugs.
Researchers have shown that bacterial communication can be intercepted and chemically manipulated to control group behavior, such as virulence or the production of a useful products.
Researchers have converted cells from individuals with ten different diseases, including muscular dystrophy, juvenile diabetes, and Parkinson's disease, into stem cells.
Scientists have identified more than 300 human genes that influence West Nile virus infection. More than 20 of these cooperate with the virus, whereas the others help cells resist it.
Clayton, who joined HHMI in 1996, has announced that he will retire on August 31.
Researchers have used new technology to pinpoint a critical gene mutation in worms in only a few weeks. It would have taken years for scientists using older technology to sift through the worm's DNA until they found the proverbial needle in the haystack.
Researchers have identified a genetic defect that makes some children susceptible to attack by a certain type of bacteria, a finding that will speed up diagnosis and treatment.
Investigadores del HHMI han identificado dos drogas que imitan muchos de los efectos fisiológicos del ejercicio. Las drogas aumentan la capacidad de las células de quemar grasa y son las primeras sustancias que se han demostrado mejoran la resistencia para el ejercicio.
HHMI researchers have identified two drugs that mimic many of the physiological effects of exercise.
Researchers have revealed an important step in the process that guides neurons as they establish precise connections between the spinal cord and muscles.
An international team of researchers has identified a gene mutated in Duane syndrome, a common disorder that restricts the movement of the eyes.
Thanks to a set of fruit flies that seem to get by with far less dozing than most, researchers has found a gene absolutely necessary for snoozing.
By focusing on large families in which both parents share a recent ancestor, scientists have honed in on rare mutations that had remained elusive in previous studies.
HHMI-supported scientists have created MitoCarta, an online atlas of more than 1,000 proteins that healthy mitochondria use to keep cells running smoothly—a tool that should help researchers understand what happens when things go wrong.
HHMI international scholar Alan Cowman has set out to understand the proteins that oversee malaria's destruction and rebuilding of red blood cells.
Scientists may be able to stave off influenza infection by targeting one of more than 100 proteins inside host cells on which the virus depends.
Pavel Pevzner has created a class that turns undergraduates into experts on genome annotation.
HHMI has appointed Marian Carlson as senior scientific officer. Carlson will work from the Institute's headquarters to support the research of HHMI investigators across the nation.
New research has uncovered the mechanism that guides vertebral development in the early embryo.
New research has uncovered the mechanism that guides vertebral development in the early embryo.
HHMI researchers have developed a mouse model of osteosarcoma, the most common form of bone cancer.
A new model reveals that three classes of HIV drugs inhibit the virus more than 10,000 times better than others
Nuevo modelo matemático revela que tres clases de drogas contra el VIH inhiben al virus 10.000 veces mejor que otras.
Researchers have identified a chemical messenger that helps different sites on individual neurons coordinate with one another.
Medical, dental and, for the first time, veterinary students will get a chance to conduct biomedical research full time for a year.
Scientists who bridge the gap between basic research and clinical medicine will get a boost at a vital time in their career.
Scientists have demonstrated how protocells might have taken up nutrients from the earth's early environment to propel their growth.
Scientists have discovered that the mutation that causes Rett syndrome interferes with the regulation of 2,500 other genes.
Fifty-six of the nation's most creative biomedical scientists are being given the opportunity to tackle their most ambitious, risky research plans as they become the newest class of HHMI investigators.
A protein previously thought to identify only colon cancer stem cells is actually prevalent throughout primary colon tumors.
A prominent protein on the surface of liver cells protects organisms during sepsis, one of the most common and deadly side effects of bacterial infection.
HHMI researchers bring the arcane world of protein folding to the online gaming arena with the launch of "Foldit."
Investigadores del HHMI acercan el arcano mundo del plegamiento proteico al terreno de juegos en Internet con el lanzamiento de “Pliégalo”.
Researchers have produced the first high-resolution map showing the structural variation that exists in the human genome.
A mutant RNA may be partially to blame for the neurodegeneration associated with spinocerebellar ataxia type 3.
Four HHMI investigators, an HHMI professor, and two members of the Institute's advisory boards have been elected to the National Academy of Sciences.
David Asai has been named director of the undergraduate science education program at HHMI.
Eight HHMI investigators and three HHMI professors are among the 190 new fellows and 22 foreign honorary members elected.
Vision has improved in all three patients who have received gene therapy for a rare but severe form of retinal degeneration.
A searchable database of interviews with notable scientists and public figures now available from the Howard Hughes Medical Institute.
Forty-eight of the nation's best undergraduate institutions will receive $60 million to help them usher in a new era of science education.
A complete listing of this year's college grant recipients with links to profiles of each institution.
Just three years after discovering a genetic mutation that causes a trio of leukemias, HHMI researchers have helped move a new leukemia drug into clinical trials.
HHMI researchers identify rare mutations in three genes that contribute to blood pressure variation in the general population.
Investigadores del HHMI han encontrado que mutaciones raras en tres genes contribuyen a variaciones en la presión arterial de la población general.
Jeremy R. Knowles, an HHMI Trustee, died yesterday at his home in Cambridge, Massachusetts, following a long bout with prostate cancer.
A new picture of a genetic parasite is helping researchers see how specialized segments of RNA escape from their positions in the genome and invade new ones.
Thomas R. Cech, President of HHMI since January 2000, today announced that he would step down as head of the Institute in spring 2009.
A new DVD provides an in-depth look at the challenges facing physicians, scientists, and others on the front lines of the global AIDS epidemic.
New studies provide a fresh view of the computational power of neurons.
Charles Zuker will deliver a lecture titled "Common Sense about Taste–from the Tongue to the Brain: How We Transform Sensation into Perception" on April 23, 2008.
Researchers have identified hundreds of genes that keep embryonic stem cells in their characteristic malleable state.
Researchers have designed and built two functional enzymes never seen in nature.
Con la ayuda de la donación de tiempo computacional de miles de personas en todo el mundo, Investigadores del HHMI han diseñado y construido dos enzimas funcionales nunca antes vistas en la naturaleza.
A cellular gatekeeper inside a malaria parasite doesn't care whether the amino acid letters on a protein's entry ticket are out of order.
Researchers studying spinocerebellar ataxia have uncovered a pathological mechanism that may also underlie more common neurological diseases.
HHMI announces a major new program that will provide much-needed support to some of the nation's best early career faculty.