HHMI researchers have identified 27 genes in brain stem cells that are prone to a type of DNA damage called double-strand breaks.
New study suggests why mice with cystic fibrosis mutations can stave off bacterial infections in their lungs.
New experiments at HHMI's Janelia Research Campus show that activity in the cortex is critical for enacting a learned skill.
The MouseLight Project team at Janelia unveils a microscope and method for long-range tracing of neurons in the mouse brain.
New study suggests that graded changes in gene expression are an organizing principle for CA1 pyramidal cells in the hippocampus.
On February 24, HHMI investigator Bonnie Bassler will deliver a talk, “Tiny Conspiracies: Cell-to-Cell Communication in Bacteria,” at 7:00 p.m. at Janelia Research Campus.
Research uncovers new information about the biological processes that help ensure that two fly species don't interbreed.
HHMI researchers have discovered a molecular mechanism that enables plants to detect when they are in the shade of other plants and adapt by speeding up their growth.
Using an advanced imaging system with adaptive optics, Janelia scientists have uncovered new details about how the brain processes visual information.
New research examines why some children born with heart defects also have developmental disabilities.
Researchers learn more details about how CRISPR works in cells.
Scientists show they can control whether mice perceive a taste as bitter or sweet by activating two small areas of the brain.
HHMI investigators Karl Deisseroth and Helen Hobbs are among five scientists honored for transformative advances toward understanding living systems and extending human life.
HHMI scientists have identified a set of proteins that plays a surprisingly broad role in guiding tissue formation in plant roots.
Within less than a second, the new IsoView microscope produces images of entire organisms, such as a zebrafish or fruit fly embryo, with enough resolution in all three dimensions that each cell appears as a distinct structure.
HHMI's Paul Modrich shares 2015 Nobel Prize in Chemistry with Tomas Lindahl and Aziz Sancar for studies of DNA repair.
New research indicates individual human neurons may harbor up to 1,000 genetic mutations.
HHMI Investigator Stephen Elledge of Brigham and Women's Hospital shares the 2015 Albert Lasker Basic Medical Research Award with Evelyn Witkin of Rutgers University.
New imaging methods dramatically improve the spatial resolution provided by structured illumination microscopy, one of the best imaging techniques for seeing inside living cells.
HHMI scientists have discovered how the most common genetic defect in amyotrophic lateral sclerosis kills nerve cells.
HHMI researchers solve a longstanding mystery about the origin of new cells in the liver.
A lipid molecule called EET helps blood-forming stem cells replenish the immune system.
New research begins to explain how plants separate microbes they like from those they don't like.
HHMI scientists have profiled key features of the genetic material inside three types of brain cells and found vast differences in the patterns of chemical modifications that affect how the genes in each type of neuron are regulated.
New studies provide the first genetic evidence that humans interbred with Neanderthals in Europe.
New technology developed by HHMI researchers makes it possible to test for current and past infections with any known human virus by analyzing a single drop of blood.
Nueva tecnología desarrollada por investigadores del HHMI hace que se pueda utilizar una gota de sangre de una persona para analizar infecciones presentes y pasadas con cualquier virus humano conocido.
New research hints at strategies fruit flies use to keep track of where they are going, even when it's dark.
Studying fruit fly larvae, Janelia scientists have mapped the entire neural circuit involved in combining vibration and pain sensations used in triggering an escape behavior.
Negative emotions associated with hunger can make it hard to maintain a diet and lose weight. Hunger-sensitive cells in the brain may help explain that struggle.
HHMI researchers develop a new single-cell imaging technique that reveals the copy numbers and locations of thousands of RNA molecules inside a cell.
HHMI researchers identify a rare genetic mutation that tamps down immune response to influenza.
HHMI scientists have designed a revolutionary "3D printer" for small molecules that could open the power of customized chemistry to many.
Scientist at Janelia Research Campus wins The Brain Prize for helping to develop a tool that advances our understanding of how the brain's networks process information.
A new way of thinking challenges standard notions about what a herpes vaccine should look like.
Scientists at Janelia Research Campus have identified a neural circuit that connects motor planning to movement.
A new tool developed at HHMI's Janelia Research Campus lets scientists permanently mark neurons that are active at a particular time.
New studies by HHMI scientists show how cells use sophisticated signaling mechanisms to control production of interferon.
HHMI researchers have identified a neural circuit in the subfornical organ that regulates thirst in mice.
When battling a chronic infection, killer T cells must take a break so they can continue to fight off infection.
Janelia researchers show that Hox proteins trigger gene activity through weak interactions at previously unrecognized DNA binding sites in the genome.
Scientists have determined new structures of an essential cellular recycling machine with near atomic-level detail. The structures, which show a protein called NSF alone and interacting with its target, a protein complex called SNARE that is formed when membranes fuse together.
HHMI scientists and their colleagues discover a new mechanism of protein synthesis.
Researchers at HHMI's Janelia Research Campus have used motion-capture technology to reveal new insight into the sophisticated information processing and acrobatic skills of dragonflies on the hunt.
HHMI investigator Jennifer Doudna is among six scientists honored for transformative advances toward understanding living systems and extending human life.
Lattice light sheet microscopy, a new imaging platform developed at Janelia, lets biologists see 3-D images of subcellular activity in real time.
Eric Betzig, director de grupo en Janelia, gana el Premio Nobel por el desarrollo de la microscopía de fluorescencia de super-resolución.
Janelia group leader Eric Betzig wins Nobel Prize for the development of super-resolved fluorescence microscopy.
Retracing the ancient battles between jumping genes and the defenses human cells deploy to keep them in check.
Janelia scientists are learning how the brain switches between random and strategic modes.